“…A total of six animal-based studies were included in this systematic review [ 18 , 20 , 21 , 22 , 25 , 26 ] covering a timeframe of 7 years from 2014 to 2020 and conducted in several educational institution in Malaysia ( n = 5) [ 20 , 21 , 22 , 25 , 26 ] and China ( n = 1) [ 18 ]. All the included studies were parallel interventional studies aimed to investigate the effect of EBN on cognitive functions of experimental animals as a primary outcome [ 18 , 20 , 21 , 22 , 26 ], except for the study by Zhiping et al [ 25 ] aimed to investigate the effect of EBN on oxidative stress in the hippocampal of animals. However, the health status of the recruited animal models was different, which measure the effect of EBN in animals with normal cognitive functions [ 18 , 26 ], ovariectomized-induced cognitive dysfunction [ 21 , 22 , 26 ] or lipopolysaccharide-induced cognitive dysfunction [ 20 ].…”