2017
DOI: 10.1155/2017/7205082
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Edible Bird’s Nest Prevents Menopause‐Related Memory and Cognitive Decline in Rats via Increased Hippocampal Sirtuin‐1 Expression

Abstract: Menopause causes cognitive and memory dysfunction due to impaired neuronal plasticity in the hippocampus. Sirtuin-1 (SIRT1) downregulation in the hippocampus is implicated in the underlying molecular mechanism. Edible bird's nest (EBN) is traditionally used to improve general wellbeing, and in this study, we evaluated its effects on SIRT1 expression in the hippocampus and implications on ovariectomy-induced memory and cognitive decline in rats. Ovariectomized female Sprague-Dawley rats were fed with normal pel… Show more

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Cited by 20 publications
(23 citation statements)
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“…A total of 355 records were retrieved form the four online databases and one record from extra sources. According to the eligibility criteria, six relevant studies to the effect of EBN on cognitive functions were included [ 18 , 20 , 21 , 22 , 25 , 26 ], ( Figure 1 ).…”
Section: Resultsmentioning
confidence: 99%
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“…A total of 355 records were retrieved form the four online databases and one record from extra sources. According to the eligibility criteria, six relevant studies to the effect of EBN on cognitive functions were included [ 18 , 20 , 21 , 22 , 25 , 26 ], ( Figure 1 ).…”
Section: Resultsmentioning
confidence: 99%
“…A total of six animal-based studies were included in this systematic review [ 18 , 20 , 21 , 22 , 25 , 26 ] covering a timeframe of 7 years from 2014 to 2020 and conducted in several educational institution in Malaysia ( n = 5) [ 20 , 21 , 22 , 25 , 26 ] and China ( n = 1) [ 18 ]. All the included studies were parallel interventional studies aimed to investigate the effect of EBN on cognitive functions of experimental animals as a primary outcome [ 18 , 20 , 21 , 22 , 26 ], except for the study by Zhiping et al [ 25 ] aimed to investigate the effect of EBN on oxidative stress in the hippocampal of animals. However, the health status of the recruited animal models was different, which measure the effect of EBN in animals with normal cognitive functions [ 18 , 26 ], ovariectomized-induced cognitive dysfunction [ 21 , 22 , 26 ] or lipopolysaccharide-induced cognitive dysfunction [ 20 ].…”
Section: Resultsmentioning
confidence: 99%
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