Edgar G. Ulmer

Isenberg, Noah

doi:10.1525/9780520957176

Cited by 3 publications

(1 citation statement)

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“…at. 1990, Isenberg 1991], including scinderin [Rodríguez Del ]. F-Sc1, a fusion protein obtained by the expression of scinderin's domain Sc1 in prokaryotes, binds PS and PIP 2 in a Ca 2+ -dependent manner [Marcu et.…”

Section: Molecular Structure and Function Of Scinderinmentioning

confidence: 99%

Scinderin, an Actin Severing and Nucleating Protein: Molecular Structure and Possible Roles in Cell Secretion, Maturation, Differentiation and Cancer

Trifaró

2019

scirevfew

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Scinderin is a filamentous actin-severing and capping protein. Segmental deletion and point-mutation studies have shown that this scinderin actin-severing activity resides in its NH2 terminal half, precisely in domains 1 and 2. The actin nucleating activity of scinderin is in its domain 5. Scinderin’s F-actin severing activity plays a role in cell secretion. In secretory cells, scinderin is highly concentrated in the cell cortex, showing a distribution similar to that of filamentous actin. Two PIP2-binding sites have been described in scinderin domains 1 and 2. PIP2 inhibits the actin-severing activity of the protein. Several approaches [recombinant scinderin, antisence oligonucleotide, gene promoter activation, vector-mediated expression of scinderin active domains] were used to prove the role of scinderin in secretion. The promoter of SCIN, the scinderin gene, has been characterized and its responsive elements have been described. The activation of the SCIN promoter by two ligands of the aryl hydrocarbon receptor [AhR] transcription factor has been shown. This activation increased scinderin expression with a resulting increase in stimulation-induced cortical actin disassembly and exocytosis. A role for scinderin in the life cycle of megakaryocytes has also been demonstrated. Scinderin seems to be involved in the maturation, differentiation and apoptosis processes of these cells, releasing newly formed platelets. This completes the life cycle of a megakaryocyte. A role for scinderin in cancer is also emerging. The SCIN gene is silenced in megakaryocyte leukemia cells and its re-expression induces cell maturation, differentiation, apoptosis, as well as the release of platelet-like particles and anti-tumor effects. These are always accompanied by changes in cell morphology due to cytoskeleton re-arrangements. Scinderin over-expression is necessary to see anti–proliferation effects, which are always accompanied by maturation and differentiation. If there were methods to differentiate other types of tumor cells, a new area of treatment would be developed by inducing “cell maturation and/or differentiation”.

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Section: Molecular Structure and Function Of Scinderinmentioning

confidence: 99%

Scinderin, an Actin Severing and Nucleating Protein: Molecular Structure and Possible Roles in Cell Secretion, Maturation, Differentiation and Cancer

Trifaró

2019

scirevfew

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Lessons in “Bad Love”: Film Noir and the Rise of the American Oil Regime in Edgar G. Ulmer's Detour (1945)

Pangborn¹

2020

J. Am. Stud.

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This article examines Edgar G. Ulmer's Detour (1945) as an example of film noir's exploration of the affective dimension of early oil-regime America. Drawing on the work of energy-humanities scholars, the article finds the film, and by extension the genre, providing a much-needed ground-level perspective on the efforts of industry and government to stimulate oil consumption by creating desires in a public struggling with the inherent paradoxes of new technologies, foremost among them the car. The automobile gave rise to “automobility,” seemingly an expansion of democratic freedoms, yet that new way of life also entrapped its participants within destructive habits of consumption involving an entire suite of beliefs, practices, habits, and other technologies. These features of the new life, in turn, were understood within a racialized narrative of whiteness to be productive rather than extractive habits. The shadowy and fated network to which film noir gestures, the article thus argues, is not some abstract metaphysical contemplation or generalized conclusion on a period of war, but a felt recognition of the ways the rapidly expanding network of extraction, distribution, and consumption was compelling Americans to remake their lives in dramatic ways that felt beyond their control.

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FROM TEXT TO SCREEN: CELLULOID HELENS AND FEMALE STARDOM IN THE 1950s

Nikoloutsos

2015

Camb. class. j.

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This paper investigates the visual recreation of Helen in the medium of cinema by using as case studies two runaway productions of the 1950s: L'amante di Paride starring Hedy Lamarr and Helen of Troy with Rosanna Podestà in the title role. Examination of features such as costumes, makeup and hairstyle shows that in the former film Helen's representation is informed by and seeks to capitalize on Lamarr's status as a queen of glamour, equating Greek royalty with Hollywood royalty. The analysis of the second film explores further the homology between ancient and modern celebrity on screen and in extra-cinematic discourses, and shows how Podestà's stardom was built on and remained anchored in Helen's iconicity.

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Edgar G. Ulmer

Cited by 3 publications

References 0 publications

Scinderin, an Actin Severing and Nucleating Protein: Molecular Structure and Possible Roles in Cell Secretion, Maturation, Differentiation and Cancer

Scinderin, an Actin Severing and Nucleating Protein: Molecular Structure and Possible Roles in Cell Secretion, Maturation, Differentiation and Cancer

Lessons in “Bad Love”: Film Noir and the Rise of the American Oil Regime in Edgar G. Ulmer's Detour (1945)

FROM TEXT TO SCREEN: CELLULOID HELENS AND FEMALE STARDOM IN THE 1950s

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