Edematous Bullae: An Atypical Presentation of Reperfusion Injury. A Discussion of Ischemic-reperfusion Injury and Presentation of an Atypical Case

Abstract

There is vast literature on the topic of ischemia-reperfusion injury. A summative discussion of the complex pathogenicity will aid practicing physicians in diagnosis and management. We offer a review of this literature as well as a discussion on a rare case of tense edematous bullae as a presentation of ischemia-reperfusion injury. A 65-year-old male underwent a right femoropopliteal bypass for rest pain that had not improved after iliac stent placement. He presented three days after discharge with blistering lesions on the reperfused limb that resembled bullous pemphigoid. This case describes the variability in the presentation of reperfusion injury, as well as the necessity to educate those managing atypical presentations of reperfusion injury.

Effect of Thiamine Pyrophosphate Upon Oxidative Brain Injury Induced by Ischemia-Reperfusion in Rats

“…Therefore, it is necessary to restore blood flow to ischemia tissue. However, molecular oxygen delivered to the ischemia tissue with large amounts of arterial blood during reperfusion causes excessive production of free oxygen radicals (ROS) in the tissue 3 . This has been known as Ischemia-Reperfusion (I/R) injury.…”