Edema in Peripheral Nerves

Escolá, Jaume; Krücke, W.; Thomas, E.

doi:10.1007/978-3-7091-7545-3_18

Cited by 3 publications

(1 citation statement)

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“…The effect of cold upon axonal morphology has been found by some workers to be severe (Smith et al, 1915;Blackwood and Russell, I943;Large and Heinbecker, 1944;Denny-Brownetal., I945) and by other workers to be negligible (Rodriguez Echandia, 1968;Mira, 1969). If the temperature of the nerve is dropped below freezing for more than a few seconds, however, degeneration always results (Bielschowsky and Valentin, 1922;Denny-Brown et al, 1945;Escola et al, 1967;Mira and Pficot, 197 I). The freezing lesion is always reported to affect all fibres equally, whereas the cooling lesion is more controversial.…”

Section: Basbaummentioning

confidence: 97%

Induced hypothermia in peripheral nerve: Electron microscopic and electrophysiological observations

Basbaum

1973

J Neurocytol

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SummaryLocalized cooling of the cat sciatic nerve was achieved by application of a thermoelectric device to the exposed nerve at mid-thigh. The temperature of the nerve was maintained at 5°C for z h. Before, during, and after cooling, the response of the nerve to electrical stimulation was monitored, and compared with responses obtained in normothermic control preparations. In all cases, dropping the temperature of the nerve to 5°C resulted in total nerve block, and in all cases, function was restored when cooling stopped. Light and electron microscopic analysis of the cooled nerves revealed that despite functional recovery, a lesion affecting large myelinated axons developed over the course of 7 days. Both Wallerian degeneration and segmental demyelination occurred. Unmyelinated fibres were not affected.

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Section: Basbaummentioning

confidence: 97%