Induced hypothermia in peripheral nerve: Electron microscopic and electrophysiological observations

Basbaum, Carol

doi:10.1007/bf01474719

Cited by 46 publications

(14 citation statements)

References 49 publications

(7 reference statements)

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“…The present values are in bility of nerve fibres in the Trembler close agreement with those of Byck et al (1972) conduct rapid trains of impulses is of and Basbaum (1973) who reported values of 5.3°C cal importance since high frequency disand 5.0°C respectively in their studies on cat cur in normal sensory nerves in animals saphenous and sciatic nerves. I McIntyre, 1960a,b) and man (Hensel The mechanism of cold block was considered by an, 1960).…”

Section: Discussionsupporting

confidence: 86%

Refractory period, conduction of trains of impulses, and effect of temperature on conduction in chronic hypertrophic neuropathy.

Low¹,

McLeod²

1977

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionsupporting

confidence: 86%

Refractory period, conduction of trains of impulses, and effect of temperature on conduction in chronic hypertrophic neuropathy.

Low¹,

McLeod²

1977

Journal of Neurology, Neurosurgery & Psychiatry

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“…This can lead to dysfunction that is equivalent to peripheral paralysis and can, again, result in drowning owing to the inability to keep the airway clear of the water (Clarke et al . ; Basbaum, ; Golden & Tipton, ; Fig. ).…”

Section: Introduction: Historymentioning

confidence: 96%

Cold water immersion: kill or cure?

Tipton

Collier

Massey

et al. 2017

Experimental Physiology

126

103

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What is the topic of this review? This is the first review to look across the broad field of 'cold water immersion' and to determine the threats and benefits associated with it as both a hazard and a treatment. What advances does it highlight? The level of evidence supporting each of the areas reviewed is assessed. Like other environmental constituents, such as pressure, heat and oxygen, cold water can be either good or bad, threat or treatment, depending on circumstance. Given the current increase in the popularly of open cold water swimming, it is timely to review the various human responses to cold water immersion (CWI) and consider the strength of the claims made for the effects of CWI. As a consequence, in this review we look at the history of CWI and examine CWI as a precursor to drowning, cardiac arrest and hypothermia. We also assess its role in prolonged survival underwater, extending exercise time in the heat and treating hyperthermic casualties. More recent uses, such as in the prevention of inflammation and treatment of inflammation-related conditions, are also considered. It is concluded that the evidence base for the different claims made for CWI are varied, and although in most instances there seems to be a credible rationale for the benefits or otherwise of CWI, in some instances the supporting data remain at the level of anecdotal speculation. Clear directions and requirements for future research are indicated by this review.

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“…The axon was visualized by the expression of green fluorescent protein (GFP) after transfection of the neuron with a plasmid expressing GFP. Both increases and decreases in temperature have been shown to cause axonal damage, as in the case of hyperthermia or hypothermia [32–34]. At the beginning of imaging, the heating stage of the live-cell culture chamber was switched off to gradually reduce the temperature of the neuronal culture from 37 to 22.6°C (room temperature; fig.…”

Section: Resultsmentioning

confidence: 99%

AxonQuant: A Microfluidic Chamber Culture-Coupled Algorithm That Allows High-Throughput Quantification of Axonal Damage

Yang

Huang

et al. 2014

Neurosignals

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Published methods for imaging and quantitatively analyzing morphological changes in neuronal axons have serious limitations because of their small sample sizes, and their time-consuming and nonobjective nature. Here we present an improved microfluidic chamber design suitable for fast and high-throughput imaging of neuronal axons. We developed the AxonQuant algorithm, which is suitable for automatic processing of axonal imaging data. This microfluidic chamber-coupled algorithm allows calculation of an ‘axonal continuity index' that quantitatively measures axonal health status in a manner independent of neuronal or axonal density. This method allows quantitative analysis of axonal morphology in an automatic and nonbiased manner. Our method will facilitate large-scale high-throughput screening for genes or therapeutic compounds for neurodegenerative diseases involving axonal damage. When combined with imaging technologies utilizing different gene markers, this method will provide new insights into the mechanistic basis for axon degeneration. Our microfluidic chamber culture-coupled AxonQuant algorithm will be widely useful for studying axonal biology and neurodegenerative disorders. © 2014 S. Karger AG, Basel

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Induced hypothermia in peripheral nerve: Electron microscopic and electrophysiological observations

Cited by 46 publications

References 49 publications

Refractory period, conduction of trains of impulses, and effect of temperature on conduction in chronic hypertrophic neuropathy.

Refractory period, conduction of trains of impulses, and effect of temperature on conduction in chronic hypertrophic neuropathy.

Cold water immersion: kill or cure?

AxonQuant: A Microfluidic Chamber Culture-Coupled Algorithm That Allows High-Throughput Quantification of Axonal Damage

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