Eddy current thermal effect based on magnesium microrods for combined tumor therapy

Yang, Xiaocui; Yang, Nailin; Zhang, Lei; Zhao, Dongxu; Lei, Huali; Cheng, Shuning; Ge, Gun; Ma, Xiaoming; Ni, Caifang; Liu, Zhuang; Cheng, Liang

doi:10.1016/j.cej.2022.137038

Cited by 10 publications

(7 citation statements)

References 34 publications

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“…Enhancing chemotherapy’s efficacy often involves combining it with complementary cancer treatment methods like magnetic therapy [ 122 , 123 ], radiation therapy [ 124 ], and hyperthermia [ 125 ], among others. Hence, the integration methods of metal or magnetic nanoparticles with electrospinning are common approaches.…”

Section: Application Of Drug-loaded Nanofibers In Cancer Therapymentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

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In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This approach minimizes patient discomfort associated with multiple-drug administration. Electrospun fibers not only transport drugs but can also integrate metal particles and targeted compounds, enabling combinations of chemotherapy with magnetic and heat therapies for comprehensive cancer treatment. This review delves into electrospinning preparation techniques and drug delivery methods tailored to various cancers, foreseeing their promising roles in cancer treatment.

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Section: Application Of Drug-loaded Nanofibers In Cancer Therapymentioning

confidence: 99%

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Yang,

Zhang,

Liang

et al. 2024

Polymers

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“…After that, palladium–cobalt (PdCo) binary alloys and some others (e.g., FePt, CoNi, NiTi) were successfully prepared to enable reproducible heating of tumors in the temperature range of 50–100 °C after a single implantation. ,− Despite the high induction heating efficacy, some of these thermoseeds tend to degrade upon intratumoral implantation and cause potential safety concerns. Therefore, magnesium (Mg) alloys, a widely used biocompatible metal with varying biomedical applications in clinics, were recently shown to be a promising candidate to enable effective MHT of diverse tumors by our groups , It was found that the customized Mg alloy rods under an AMF showed obvious length-dependent and diameter-dependent temperature increases originating from the eddy thermal effect (Figure ). Under a low-field-intensity AMF, Mg alloy rods could be rapidly heated to induce a rapid temperature increase in nearby tumor tissues, thereby enabling efficient elimination of bother subcutaneous murine tumors and larger-sized rabbit tumors.…”

Section: Design Rationales Of Biomaterials To Assist Tumor Localized ...mentioning

confidence: 99%

Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Zhu

Wang

et al. 2023

Chem. Rev.

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Cancer thermal therapy, also known as hyperthermia therapy, has long been exploited to eradicate mass lesions that are now defined as cancer. With the development of corresponding technologies and equipment, local hyperthermia therapies such as radiofrequency ablation, microwave ablation, and high-intensity focused ultrasound, have has been validated to effectively ablate tumors in modern clinical practice. However, they still face many shortcomings, including nonspecific damages to adjacent normal tissues and incomplete ablation particularly for large tumors, restricting their wide clinical usage. Attributed to their versatile physiochemical properties, biomaterials have been specially designed to potentiate local hyperthermia treatments according to their unique working principles. Meanwhile, biomaterial-based delivery systems are able to bridge hyperthermia therapies with other types of treatment strategies such as chemotherapy, radiotherapy and immunotherapy. Therefore, in this review, we discuss recent progress in the development of functional biomaterials to reinforce local hyperthermia by functioning as thermal sensitizers to endow more efficient tumor-localized thermal ablation and/or as delivery vehicles to synergize with other therapeutic modalities for combined cancer treatments. Thereafter, we provide a critical perspective on the further development of biomaterial-assisted local hyperthermia toward clinical applications.

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“…Alternating magnetic field (AMF), which is not limited by tissue penetration depth, has garnered widespread attention as a local treatment tool recently, such as magnetic hyperthermia therapy (MHT) [ [30] , [31] , [32] , [33] ]. With the development of novel biomaterials and biotechnologies, the eddy-thermal effect generated by Faraday's law of electromagnetic induction allows macroscopic conductors with low resistivity and high conductivity, exemplified by magnesium (Mg) implants, to generate induced current heating under AMFs [ 34 , 35 ]. Based on the eddy-current effect, several research groups, including our group, have carried out a series of research works on MHT of tumors using macroscopic metals, including Mg implants [ 36 , 37 ].…”

Section: Introductionmentioning

confidence: 99%

Magnesium implants with alternating magnetic field-enhanced hydrogen release and proton depletion for anti-infection treatment and tissue repair

Yang,

Cheng

et al. 2024

Bioactive Materials

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Eddy current thermal effect based on magnesium microrods for combined tumor therapy

Cited by 10 publications

References 34 publications

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy

Rational Design of Biomaterials to Potentiate Cancer Thermal Therapy

Magnesium implants with alternating magnetic field-enhanced hydrogen release and proton depletion for anti-infection treatment and tissue repair

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