Edaravone, a free radical scavenger, protects liver against valproic acid induced toxicity

Cakmak, Neziha Hacihasanoglu; Yanardağ, Refiye

doi:10.2298/jsc140812123c

Cited by 4 publications

(4 citation statements)

References 57 publications

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“…On the other hand, edaravone treatment resulted in the restoration of these enzymes activity. Similar results were reported by Hacihasanoglu Cakmak and Yanardag [3] and Gezginci-Oktayoglu et al [4], respectively. SDH reversibly catalyzes the oxidation reaction of sorbitol to fructose with the cofactor NAD.…”

Section: Discussionsupporting

confidence: 89%

“…SDH activity notably declined when the rats were treated with edaravone. Similar findings were reported by Hacihasanoglu Cakmak and Yanardag [3]. A decrease in SDH activity may have caused an improvement in testicular tissue following edaravone administration.…”

Section: Discussionsupporting

confidence: 88%

“…Group III (n = 10) were given only VPA i.p. (500 mg/kg/day) for seven days [3], and lastly, Group IV (n = 10) which were given VPA+ edaravone i.p. (at the same dose and at the same time).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

“…Also, it is used as an antineoplastic agent via its histone deacetylase inhibition [2]. Long-term use of VPA has been reported to have some toxic and/or side effects on several organs such as the liver [3], kidney [4], and testis [5]. In recent years, studies have shown that VPA has adverse effects on male reproductive system (sperm motility) in both male epileptic patients [6] and experimental animal model [7].…”

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confidence: 99%

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Protective effect of edaravone on rat testis after valproic acid treatment

CELIK¹,

Bayrak²,

Cakmak³

et al. 2022

jrp

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Valproic acid (n-dipropyl-acetic acid, VPA) is a medication used as anticonvulsant in the treatment of bipolar disorder, and for migraine prophylaxis. Long-term use of VPA is known to trigger reproductive impairment, which is mediated by elevation of testicular oxidative stress. Edaravone is used in the treatment of cerebrovascular diseases. It can diffuse into many disease-affected organs, thus shows protective effects in numerous tissues including the heart, lung, and testis. The main goal of the present study was to determine the possible protective role of edaravone against VPA-induced oxidative testicular injury. Male Sprague Dawley rats were assigned into four groups. Control rats; rats given only edaravone (30 mg/kg/day); rats given only VPA (500 mg/kg/day); rats given VPA+edaravone for seven days. Edaravone and VPA were applied intraperitoneally. After eight days, testicular tissues were taken from rats. There was a statistically significant increase in the levels of reduced glutathione, lipid peroxidation, reactive oxygen species, total oxidant status, oxidative stress index, and DNA contents as well as catalase, superoxide dismutase, glutathione-related enzymes, gamma-glutamyl transferase, acid and alkaline phosphatases, lactate dehydrogenase, myeloperoxidase and sorbitol dehydrogenase activities in VPA group. More so, advanced oxidized protein products, protein carbonyl, and nitric oxide levels were also significantly increased in VPA group. Activities of glucose-6phosphate dehydrogenase and sodium/potassium ATPase and total antioxidant status levels remarkably decreased in VPA given group. Treatment with edaravone to VPA group significantly reverted these alterations. These findings demonstrate that administration of edaravone has a beneficial effect against testicular injury in VPA-induced oxidative stress.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 88%

“…Group III (n = 10) were given only VPA i.p. (500 mg/kg/day) for seven days [3], and lastly, Group IV (n = 10) which were given VPA+ edaravone i.p. (at the same dose and at the same time).…”

Section: Animals and Experimental Designmentioning

confidence: 99%

mentioning

confidence: 99%

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Protective effect of edaravone on rat testis after valproic acid treatment

CELIK¹,

Bayrak²,

Cakmak³

et al. 2022

jrp

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The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

Bayrak

Yılmaz

Cakmak

et al. 2021

J Biochem & Molecular Tox

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In this study, we aimed to evaluate whether edaravone (EDA) has a protective role against valproic acid (VPA)-induced lung damage via its antioxidative activity. Male Sprague-Dawley rats were split into four groups. Control (n = 8) rats; rats given EDA (30 mg kg −1 day −1 ; n = 10); rats given only (VPA, 500 mg kg −1 day −1 ; n = 10); rats given VPA + EDA (in the same dose and time) for 7 days. EDA and VPA were applied intraperitoneally. After 8 days, lung tissues were immediately taken from the rats. In lung homogenates, reduced glutathione, total antioxidant status levels, and superoxide dismutase, glutathione peroxidase, sodium/potassium ATPase, paraoxonase1, and carbonic anhydrase activities significantly abated, whereas catalase, glutathione reductase, glutathione-S-transferase activities insignificantly decreased in the VPA-treated group. In contrast, lipid peroxidation, reactive oxygen species, and total oxidant status levels, glycoprotein and protein carbonyl contents, nitric oxide, hydroxyproline levels, and xanthine oxidase, lactate dehydrogenase, arginase, and prolidase activities significantly increased in the VPA-given group. Administration of EDA caused the reverse effects. As a consequence, EDA prevented oxidative stress-mediated lung injury via its robust antioxidant effects.

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Potential Protective Role of Radicut in Valproic Acid-Induced Oxidative Stress in Rat Spleen

Oktay,

Alev Tüzüner,

Tunalı

et al. 2024

İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi

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Aim: The study aims to evaluate the potential protective role of Radicut (RAD) in Valproic acid (VPA)-induced oxidative stress in splenic tissues of rats. Method: Rats were divided into groups as follows: Group 1: Controls (n=8), Group II: R: RAD-given group (30 mg/kg/day, n=8), Group III: V: VPA-given group (0.5 g/kg/day, n=10), Group IV: V+R: VPA+RAD-given group (30 mg/kg/day, n=11). VPA, RAD, and VPA+RAD were given to the animals for 7 days (i.p). Biochemical parameters related to oxidative stress were determined in spleen homogenates. Results: VPA elevated oxidative stress by increasing lipid peroxidation and sialic acid levels, increasing alkaline phosphatase activity, and decreasing superoxide dismutase, glutathione-S- transferase, and glutathione peroxidase activities. Administration of RAD to VPA-given group decreased LPO, SA levels, and acid phosphatase levels, and increased tissue factor, SOD, GST, and GPx activities. Conclusion: RAD reversed the biochemical results in the V group, by clarifying its protective effect. RAD has the potential to prevent oxidative stress during VPA treatment, which could be beneficial.

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Edaravone, a free radical scavenger, protects liver against valproic acid induced toxicity

Cited by 4 publications

References 57 publications

Protective effect of edaravone on rat testis after valproic acid treatment

Protective effect of edaravone on rat testis after valproic acid treatment

The effects of edaravone, a free‐radical scavenger in lung injury induced by valproic acid demonstrated via different biochemical parameters

Potential Protective Role of Radicut in Valproic Acid-Induced Oxidative Stress in Rat Spleen

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