ED95 of phenylephrine to prevent spinal-induced hypotension and/or nausea at elective cesarean delivery

Monitoramento não invasivo baseado na biorreatância revela instabilidade hemodinâmica significativa durante cesárea eletiva sob raquianestesia

“…At our institution the treatment of any recorded fall in the maternal SBP from baseline is encouraged, and phenylephrine is the first line vaso constrictor used. The ED 95 of intermittent phenylephrine boluses to prevent hypotension is quoted as at least 120 µg per bolus 16 , however, in our institution a convenience dose of 100 µg is still routinely used. In this observational study, the attending anesthesiologist was free to manage patient's SBP as per their usual practice.…”

If a little bit is wrong, how much is alright? Interpreting the significance of small numerators in clinical trials

“…A study by George et al [14] found the ED 90 of phenylephrine required for the treatment of spinal anaesthesia-induced hypotension to be 150 lg. The ED 95 of phenylephrine, found by Tanaka et al [15], was 159 lg, and the dose to prevent pre-delivery spinal-induced hypotension and nausea at elective caesarean section was 120 lg. Additionally, in the study by das Neves et al, spinal anaesthesia was achieved with only 10 mg bupivacaine [13].…”

Comparison the effect of ephedrine and phenylephrine in treatment of hypotension after spinal anesthesia during cesarean section

“…Clinical data have suggested that α-adrenergic agonists such as ephedrine or phenylephrine may be given safely for prevention or treatment of hypotension during administration of regional anesthesia for cesarean section [1,4,10]. Earlier studies have been confirmed the beneficial phenylephrine effects on umbilical pH [5][6][7][8][9][10][11][12], as phenylephrine has been recently the first line drug for this purpose [13,14]. However, more recent studies results show that some caution with the use of phenylephrine may be warranted.…”