Ectromelia Virus Multiplication in Regenerating Mouse Liver

Miller, J.D.; Burgh, P

doi:10.1038/icb.1957.14

Cited by 8 publications

(3 citation statements)

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“…Changes occur in the nucleus despite the apparent absence of viral material. In addition to the later biochemical changes, virus infection inhibits mitosis in regenerating liver as early as 10 hours after infectionthat is, early in the eclipse phase (Miller and de Burgh, 1957). Ectromelia virus has not been analysed completely, but it is most likely that, as with the closely related vaccinia virus, its nucleic acid is deoxyribonucleic acid (D.N.A.).…”

Section: Site Of Damage In Ectromelia-virus-infected Mousementioning

confidence: 99%

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On Virus Metabolism and Neoplasia

Nelson¹,

Burgh²

1960

BMJ

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HIATUS M_DIT "Why not dilate strictures ? " you ask. "The operation is safe in competent hands; the immediate results are gratifying ; the risks of alternative operations are considerable; and histological preparations have shown that, even in patients who have had a long clinical history of dysphagia, muscle may predominate over scar in the 'tumour.' Moreover, many patients have been jockeyed along from year to year by repeated endoscopies."The case against dilatation is this. Immediate relief of dysphagia is no crit-erion of cure. By stretching a stricture of this sort nature's barrier against reflux is broken down, and the inexorable complications of oesophagitis are rekindled to flame again. With each exacerbation the scar, that remains for ever, penetrates the muscle of the gullet more deeply and rises upwards in the mediastinum. The end is worse than the beginning. (1953). Thorax, 8, 38. Barrett, N. R. (1950). Brit. J. Surg., 38, 175.- (1954). Ibid., 42, 231. -(1956

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Section: Site Of Damage In Ectromelia-virus-infected Mousementioning

confidence: 99%

“…The activities of various enzymes in this system have been estimated and in part reported (de Burgh, 1957;Nelson andde Burgh, 1958, 1959). These have been compared with similar estimations in regenerating mouse liver.…”

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confidence: 99%

On Virus Metabolism and Neoplasia

Nelson¹,

Burgh²

1960

BMJ

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“…I too was given the task of deciphering how ectromelia virus multiplied in liver cells, but rather than continuing on the line of work that previous BScMed students had performed with normal liver, I thought it more interesting to determine whether the virus might interfere with some crucial biochemical events during liver regeneration after partial hepatectomy. Two papers resulted from this work (1,2).…”

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confidence: 99%

Discovering the Origins of Immunological Competence

Miller

1999

Annu. Rev. Immunol.

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Work done in the late 1950s and in the 1960s revealed the role of the thymus in virus-induced leukemia in mice. Thymectomizing mice at birth to test whether the virus first multiplied in thymus tissue and then spread elsewhere ultimately led to the conclusion that the thymus was essential to the normal development of the immune system. Subsequent testing to try to understand how the thymus contributes to the pool of immunocompetent lymphocytes opened a new chapter in immunology and required a reappraisal of many immunological phenomena and an understanding of the molecular interactions that take place during cell-tocell interactions.

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Roots: The thymus: Maestro of the immune system

Miller

1994

BioEssays

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The thymus has been an enigmatic organ for centuries. Its true function was revealed only in 1961 when it was shown to be responsible for the proper development of the immune system. This finding has revolutionized the science of immunology and has led to a better understanding of the mechanisms involved in resistance to infections and of the pathogenesis of autoimmune and immunodeficiency diseases.

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Ectromelia Virus Multiplication in Regenerating Mouse Liver

Cited by 8 publications

References 0 publications

On Virus Metabolism and Neoplasia

On Virus Metabolism and Neoplasia

Discovering the Origins of Immunological Competence

Roots: The thymus: Maestro of the immune system

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