Ectopic Production of Calcitonin

Whitelaw, Andrew; Cohen, S J

doi:10.1016/s0140-6736(73)92300-3

Cited by 19 publications

(2 citation statements)

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“…An extension of this postulate combined the K-cells with the so-called APUD (amine precursor 48 uptake and/or decarboxylation) endocrine system of polypeptide-producing endocrine, cells including those of the anterior pituitary, the parafollicular cells of the thyroid, the pancreatic islets and the gastrointestinal endocrine cells (Pearse, 1968). In agreement with this concept is the production of ectopically synthesized hormones such as calcitonin, parathormone, antidiuretic hormone and most frequently ACTH, by oat-cell carcinoma (Whitelaw & Cohen, 1973;. Although the tumour may synthesize and secrete a form of ACTH very similar if not identical to pituitary ACTH, the predominant form of ACTH in oat-cell carcinoma extracts and of circulating ACTH in these tumour patients was big ACTH (Yalow & Berson, 1973;.…”

Section: Discussionmentioning

confidence: 71%

ACTH-like activity in immune complexes of patients with oat-cell carcinoma of the lung

Havemann¹,

Gropp²,

Scheuer³

et al. 1979

Br J Cancer

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Summary.-Immune complexes could be isolated from sera of 7 patients with oat-cell carcinoma of the lung, but not from 5 normal controls, using zonal ultracentrifugation. After ultracentrifugation, fractions containing macromolecular IgG were absorbed on a protein A-sepharose column and the immune complexes were eluted and dissociated by glycin-HCl buffer at pH 3-5. The eluates were tested for the presence of tumour-associated proteins as carcinoembryonic antigen (CEA), nonspecific crossreacting antigen (NCA), a2 pregnancy associated antigen (a2PAG) and isoferritin. Whereas none of these tumour-associated antigens could be demonstrated, an ACTH-like activity was detected in the immune-complex fractions of 4 patients with oat-cell carcinoma, by radioimmuno-and bioassay. Polyacrylamide electrophoresis of an immune-complex fraction from a patient with Cushing syndrome showed ACTH-like activities, with mol. wt of 110,000, 75,000, 30,000 and <20,000 (all glycoproteins) indicating the presence of different subfractions of big ACTH.

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Section: Discussionmentioning

confidence: 71%

ACTH-like activity in immune complexes of patients with oat-cell carcinoma of the lung

Havemann¹,

Gropp²,

Scheuer³

et al. 1979

Br J Cancer

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“…50 Two-thirds of patients with oatcell carcinoma of the lung and adenocarcinoma had high concentrations of calcitonin, whereas none of the patients with squamous cell carcinoma of the lung had detectable levels. 47,[51][52][53][54] The frequency of detectable calcitonin was higher in patients with skeletal metastases than those without. 47 When the tumor was treated by chemotherapy, the plasma calcitonin was strikingly reduced.…”

Section: Ectopic Calcitoninmentioning

confidence: 99%

Endocrine Manifestations of Lung Cancer

Eisenberg¹

1988

Semin Respir Crit Care Med

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Peptide hormones as tumor markers

Vaitukaitis

1976

Cancer

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Ectopic production and secretion of hormones by a wide variety of tumors were initially recognized by signs and symptoms of excess circulating biologically active hormone. With the development of more sophisticated and sensitive techniques, it has become apparent that not all tumors secrete biologically active hormones. Some altered forms of polypeptide hormones may be in very high concentrations immunologically but be inactive biologically. On the other hand, polypeptide hormones may circulate at concentrations too low to induce clinical signs and symptoms. Consequently, new ectopic humoral syndromes have been recognized and the incidence of previously described syndromes has become considerably greater than previously recognized. Every hormone known to be normally secreted by endocrine organs or the placenta has been documented to be secreted ectopically by a wide variety of tumors. Moreover, several of those hormones may be used as biochemical markers of malignancy for both screening and monitoring of patients with documented or suspected tumors.

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Ectopic Production of Calcitonin

Cited by 19 publications

References 0 publications

ACTH-like activity in immune complexes of patients with oat-cell carcinoma of the lung

ACTH-like activity in immune complexes of patients with oat-cell carcinoma of the lung

Endocrine Manifestations of Lung Cancer

Peptide hormones as tumor markers

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