Peptide hormones as tumor markers

Vaitukaitis, Judith L.

doi:10.1002/1097-0142(197601)37:1+<567::aid-cncr2820370722>3.0.co;2-j

Cited by 31 publications

(4 citation statements)

References 52 publications

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“…Our finding of a relationship between the change of serum ICT concentrations and the change in tumour voume indicates that serum ICT could be a useful treatment marker (Vaitukaitis, 1976 Silva et al, 1976;Tashjian et al, 1976). The undifferentiated type and the oat-cell have higher serum ICT concentrations than squamous-cell carcinomas and adenocarcinomas of the lung.…”

Section: Resultsmentioning

confidence: 52%

Value of serum calcitonin estimation in clinical oncology

Mulder¹,

Hackeng²,

Silberbusch³

et al. 1981

Br J Cancer

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Summary.-In 132 consecutive patients with carcinoma of various organs, a higher serum immunoreactive calcitonin (ICT) concentration (median level 50 pg/ml) was found than in 68 normal subjects (median level 20 pg/ml). The incidence of hypercalcitoninaemia was 40%o. All 9 patients with primary liver-cell carcinoma were hypercalcitoninaemic. On the other hand, none of the 7 patients with a carcinoma of the breast had raised ICT levels. In bronchogenic cancer a relationship between ICT and cell type was found, with a predominance of high ICT in patients with oatcell and other undifferentiated types, whereas in squamous-cell carcinomas and adenocarcinomas of the lung hypercalcitoninaemia was relatively rare.When we divided all our patients according to differentiation of the tumour cell, it was found that the lower the degree of differentiation, the higher the ICT concentration, whereas opposite results were observed for CEA.When ICT and CEA were estimated concurrently, we found at least one marker increased in 70%o of our patients.Our results demonstrate that patients with metastases in the liver have more frequently an increased ICT. In addition, we conclude that lifespan can be expected to be lower in patients with high ICT levels. In a longitudinal study of 46 patients, there was a positive correlation between change in serum ICT and tumour mass.

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Section: Resultsmentioning

confidence: 52%

Value of serum calcitonin estimation in clinical oncology

Mulder¹,

Hackeng²,

Silberbusch³

et al. 1981

Br J Cancer

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“…Serum biomarkers are sensitive but not specific markers for the presence of germinal tumors (17), and the possibility exists that a poorly differentiated germ cell tumor may be mistaken for one of non-germinal origin (1 3).…”

Section: Discussionmentioning

confidence: 99%

CT in Primary Malignant Germ Cell Tumors of the Retroperitoneum

Blomlie¹,

Lien²,

Fosså³

et al. 1991

Acta Radiol

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“…Heading the list are the foetal antigens among which CEA and -foetoprotein (AFP) are foremost. Finally, ektopically formed hormones may also be considered as tumour-associated antigens (16) like HCG (seminoma, teratoma) and corticotropin (bronchial carcinoma) as well as isoenzymes, such as the/?£#7/i-isoenzyme of alkaline phosphatase (17,18). This high individual specificity excludes up till now a general diagnostic application (8)(9)(10).…”

Section: Comments On Tumour Antigensmentioning

confidence: 99%

“…HCG has been detected in the following tumours: 1) tumours of the trophoblasts (chorionepithelioma), 2) teratomas containing trophoblast components, and 3) paraiieoplastic syndrome, mainly in adenocarcinomas (16,161). Apart from pregnancy, HCG is not found in healthy subjects.…”

Section: Human Chorionic Gonadotropinmentioning

confidence: 99%

Reviews/Übersichten

1977

Clinical Chemistry and Laboratory Medicine

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Qualitative differences between normal cells and tumour cells have been demonstrated in animal models using immunological methods. So far, no soluble tumour-specific antigens have been found in man. Only quantitative differences between normal and malignant cells were detected for the following soluble antigens: foetal antigens, tumour-associated hormones and tumour-associated enzymes. Of these, carcinoembryonic antigen (CEA), a-fetoprotein (AFP) and human chorionic gonadotropin (HCG) are of limited diagnostic significance.CEA occurs in numerous normal and inflamed tissues, in benign and malignant tumours, and in various body fluids; this indicates that CEA lacks tumour specificity. The biochemical heterogeneity of CEA is primarily due to its carbohydrate moiety, whereas the antigenic determinants are probably localised on the protein moiety of the molecule. Therefore, attempts to utilise biochemical heterogeneity for the isolation of CEA fractions possessing higher specificity in radioimmunoassay have been unsuccessful. Due to the low affinity to the antibodies, antigens like normal crossreacting antigen (NCA) which show cross reaction with CEA in immunodiffusion do not affect the radioimmunological determination of CEA. Contradictory results have been reported for the correlation between the differentiation of a tumour and its CEA concentration. On the other hand, high concentrations of CEA in serum could be correlated with poorly differentiated and infiltrative tumours. From the results, so far reported in the literature, it is clear that the determination of CEA in serum is not suitable for the primary diagnosis of a cancer; however, CEA has been successfully used in follow-up studies as an indicator of metastases or the recurrence of a tumour.

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Peptide hormones as tumor markers

Cited by 31 publications

References 52 publications

Value of serum calcitonin estimation in clinical oncology

Value of serum calcitonin estimation in clinical oncology

CT in Primary Malignant Germ Cell Tumors of the Retroperitoneum

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