Ectopic osteogenesis and hematopoiesis after implantantion of bone marrow cells seeded on HAP/PLLA scaffold

Vasiljević, Perica; Najman, Stevo; Djordjevic, Ljubisa; Savić, Vojin; Vukelić, Marija Đ.; Živanov-Čurlis, Jelena; Ignjatović, Nenad; Uskokovic, Dragan

doi:10.2298/hemind0904301v

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…This is especially important when bone defects are being treated with bone substituents which must be compatible in every sense with the bone itself. Bone substituents with adequate microarchitecture enable angiogenesis and osteogenic cell propagation, which is very important for osteoreparative and osteoregenerative processes as we have already shown (Ajdukovic et al 2005;Janicijevic et al 2008;Vasiljevic et al 2009). In that sense this overview could be of benefit in further studies and for the fabrication of artificial bone substituents for bone tissue engineering.…”

Section: Discussionmentioning

confidence: 59%

“…According to our experience with rats and rabbits as animal models in bone regeneration studies, there is a need for a systematic overview on bone microarchitecture, especially in the femur and tibia which are some of the most common bone models in bone defect studies (Najman et al 2004;Ajdukovic et al 2005;Kalicanin et al 2007;Janicijevic et al 2008;Vasiljevic et al 2009;Vukelic et al 2011). The goal of this review is to describe the differences in the microarchitecture of bone tissue primarily in the most frequently used models (i.e., rabbits and rats) and human lower limb long bones depending on gender, age and different lifestyles.…”

Section: Introductionmentioning

confidence: 99%

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A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review

Cvetković¹,

Najman²,

Rajković³

et al. 2013

Vet. Med.

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Animal models are unavoidable and indispensable research tools in the fields of bone tissue engineering and experimental orthopaedics. The fact that there is not ideal animal model as well as the differences in the bone microarchitecture and physiology between animals and humans are complicate factors and make model implementation difficult. Therefore, the tendency should be directed towards extrapolation of the results from one animal model to another or from animal model to humans. So far, this is the first paper which provides an overview on the microarchitecture of lower limb long bones and discusses data related to osteon diameter, osteon canal diameter and their orientation, as well as intracortical canals and trabecular tissue microarchitecture in commonly used animal models compared to humans depending on age, gender and anatomical location of the bone. Understanding the differences between animal model and human bone microarchitecture should enable a more accurate extrapolation of experimental results from one animal model to another or from animal models to humans in the fields of bone tissue engineering and experimental orthopaedics. Also, this should be helpful in making decisions on which animal models are the most suitable for particular preclinical testing.

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Section: Discussionmentioning

confidence: 59%

Section: Introductionmentioning

confidence: 99%

A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review

Cvetković¹,

Najman²,

Rajković³

et al. 2013

Vet. Med.

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“…As we demonstrated in our study, on the surface of this material in the environment that is similar to the human body, a layer similar to the apatite is formed. The results indicate that HAp/PLLA alone, or in the combination with the blood or bone marrow, may be an adequate candidate for the potential application in the orthopedics and maxillofacial surgery (17).…”

Section: Resultsmentioning

confidence: 94%

Interaction of Biomaterials Containing Calcium Hydroxyapatite/Poly-L-Lactide With the Simulated Body Fluid

Vukelić¹,

Mitić²,

Miljković³

et al. 2011

amm

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The purpose of biomaterials is to replace a part or a function of the body in a safe, physiologically and economically acceptable way. The process of the reconstruction of bone defects has always been a big problem in orthopedics and maxillofacial surgery. Since hydroxyapatite (HAp) was detected as a component, the predominant constituent and the integral element of Mammalian bones, the development of the phospate ceramics as potential materials for implantation was enabled. This study investigated whether and in which way biomaterial calcium hydroxyapatite/poly-L-lactide (HAp/PLLA) interacts with the ionic composition of the human plasma. The simulated body fluid (SBF) is an artificial fluid that has the ionic composition and ionic concentration similar to the human blood plasma. HAp/PLLA was incubated for 1, 2, 3 and 5 weeks in SBF. The surfaces of both treated and untreated materials were analyzed on a scanning electron microscopy (SEM), and were also exposed to the energy dispersive X-ray spectroscopy (EDS), while SBF was submitted to the measuring of pH and electrical conductivity. However, our results indicate that the degradational changes of the material HAp/PLLA in SBF start from the surface of the treated material and that observed changes are the consequence of dissolution of its polymer component and the precipitation of the material similar to hydroxyapatite on its surface. This material shows good characteristics that place it among good candidates for the application in orthopedics and maxillofacial surgery.

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“…Biodegradability, reactions between the tissue and biomaterials, cytotoxicity, genotoxicity, mutagenicity etc. can be predicted trough different tests validated in vitro and in vivo (5,6,7,8), while the problem of hypersensitivity prediction in pre-clinical phase of biomaterials testing still persists.…”

Section: Biomaterials and Hypersensitivity Reactionsmentioning

confidence: 99%

Hypersensitivity Potential of Gynecological Devices

Vukelić-Nikolić¹,

Popović²,

Djordjević³

et al. 2019

amm

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Medical devices encompass an extremely wide range of products used in variety of settings for the diagnosis, prevention, monitoring or treatment of illness or disability. Development of medicine and technology causes constantly increasing number of different medical devices with characteristics corresponding to biomaterials and whose application can lead to development of hypersensitivity reactions. Despite the fact that gynecology is a wide field for biomaterials applications, there are no summarized data about hypersensitivity reactions to gynecological devices. This paper gives an overview of hypersensitivity potential and common clinical manifestations of medical devices that are specifically used in gynecology. Summarizing these data is very important for improvement of current medical practice and also for designing and creating new medical devices.

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Ectopic osteogenesis and hematopoiesis after implantantion of bone marrow cells seeded on HAP/PLLA scaffold

Cited by 5 publications

References 22 publications

A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review

A comparison of the microarchitecture of lower limb long bones between some animal models and humans: a review

Interaction of Biomaterials Containing Calcium Hydroxyapatite/Poly-L-Lactide With the Simulated Body Fluid

Hypersensitivity Potential of Gynecological Devices

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