Ectopic nephrogenic rests in children: A series of 13 cases in a single institution

Ma, Yangyang; Zheng, Jicui; Feng, Juan; Zhu, Haitao; Xiao, Xianmin; Chen, Lian

doi:10.1002/pbc.26985

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…They are mostly encountered incidentally during hernia repair or orchidopexy (15). Most children with inguinal ENR had an uneventful postoperative follow-up with no recurrence (15,36). However, the patient presented by Cook et al had local recurrence five months after ENR removal.…”

Section: Discussionmentioning

confidence: 99%

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Extrarenal Wilms tumor mimicking funicular hydrocele

Mijović,

Rašić,

Miličković

et al. 2024

Medicinska istraživanja

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Introduction/Objective: Extrarenal Wilms' tumor (ERWT) comprises 0.5% to 1% of all nephroblastoma cases. The most common locations of ERWT are the retroperitoneum, inguinal, lumbosacral and pelvic region, female genital organs, mediastinum and chest wall, spermatic cord and paratesticular region. ERWT most likely originates from the ectopic nephrogenic rest that undergoes a malignant transformation. The exclusion of primary renal tumor is necessary to establish the diagnosis of ERWT. Patient Review: A 15-month-old male was operated on because of a left-sided inguinal mass that clinically resembled a funicular hydrocele. The surgical exploration of the inguinal canal revealed a solid tumor located in the area of the external inguinal ring, measuring around 2cm in diameter, with no ingvinal hernia present. Complete surgical resection of the mass was performed. The histological structure of the tumor corresponded to non-anaplastic nephroblastoma (Wilms tumor), mixed type. After abdominal CT scan primary renal tumor was excluded and the diagnosis of ERWT was made. Because of microscopic tumor rests on the resection margin, the patient was treated according to the high-risk SIOP Wilms tumor protocol. The patient made a full recovery. During the 10-year follow-up, the boy has remained disease-free. Conclusion: ERWT is mostly diagnosed after the surgical removal of the specimen. The clinical resemblance of the ERWT located in the inguinal region to common benign inguinal conditions in children may lead to the omission of detailed preoperative work-up. Most children with ERWT in the inguinal region have an excellent prognosis, although most of them require adjuvant chemotherapy and/or radiotherapy after surgery.

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Section: Discussionmentioning

confidence: 99%

“…Correct pathological diagnosis of ENR may help to avoid unnecessary adjuvant treatment. Nevertheless, close follow-up with clinical and ultrasound examinations of the inguinal region at least bi-annually is necessary (15,36).…”

Section: Discussionmentioning

confidence: 99%

Extrarenal Wilms tumor mimicking funicular hydrocele

Mijović,

Rašić,

Miličković

et al. 2024

Medicinska istraživanja

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“…The early symptoms of retroperitoneal teratoma may not be readily evident and are non-specific; thus, they are not easily identifiable and the tumor is often misdiagnosed (10,11). Typically, symptoms become more pronounced when the tumor grows to a large size and compresses adjacent tissues or organs (12,13). However, the tumor in the present case was located in the lesser curvature of the stomach and was compressed, resulting in herniation of the lesser curvature of the stomach near the fundus.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal teratoma misdiagnosed as a gastric stromal tumor: A case report

Gan

Huang

2020

mol clin onc

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The misdiagnosis of retroperitoneal teratoma as a gastric stromal tumor is rarely reported. There are numerous abdominal organs, and retroperitoneal tumors are easily concealed by organs situated more anteriorly on the abdomen; therefore, retroperitoneal tumors are easily misdiagnosed as human digestive system tumors by abdominal surgeons. We herein present the case of a 39-year-old female patient who was diagnosed with a gastric stromal tumor (GST) on preoperative examination, whereas the postoperative diagnosis was retroperitoneal mature cystic teratoma. Such cases are clinically rare. In the present case, the tumor was located in the retroperitoneum, near the lesser gastric curvature, without an obvious gap. The anterior surface of the tumor was concealed by the lesser gastric curvature and did not move significantly with breathing and changes in posture. In such cases, a preoperative misdiagnosis is very likely. The aim of the present study was to improve our understanding of the presentation of retroperitoneal teratomas, thereby gaining more clinical experience and hopefully reducing the rate of misdiagnosis.

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