Ectopia Cordis as a Lethal Neonatal Condition: A Case Report from Bahrain and a Literature Review

Mohamed, Shereen M.; Isa, Hasan M; Sandhu, Amarjit K.

doi:10.1155/2022/6850305

Cited by 3 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, it is evident that in addition to causing harmful effects on the primary site of exposure, that is, the oral mucosa, SG can also induce harmful effects on the reproductive system of an exposed organism. Our previous study with the same compounds in chick embryos showed the manifestation of developmental disorders like microphthalmia, omphalocele, and ectopia cordis that are also caused by genetic or chromosomal aberrations (Verma and Fitzpatrick, 2007; Poaty et al, 2019; Talukdar et al, 2020; Mohamed et al, 2022). In this study, we observed that SG exposure induced DNA damage in the 11‐day‐old chick embryo, highlighting the fact that exposure of an embryo to SG during its developmental stages may induce harmful genotoxic effects on it, thereby resulting in organ‐level developmental defects.…”

Section: Discussionmentioning

confidence: 95%

Areca nut and smokeless tobacco exposure induces micronucleus, other nuclear abnormalities and cytotoxicity in early chick embryo

Mandal

Talukdar

Das

et al. 2023

Birth Defects Research

View full text Add to dashboard Cite

Areca nut (AN) and smokeless tobacco (SLT) are indiscriminately consumed among the populations of Southeast and South Asian countries, even by women during the gestational period. This study aimed to investigate the genotoxic and cytotoxic potentials of AN and Sadagura (SG), a unique homemade SLT preparation, alone and in combination in early chick embryos. Fertile white leghorn chicken eggs were randomly divided into five treatment groups: vehicle control, positive control (Mitomycin C, 20 μg/egg), AN, SG, and AN +SG. AN, SG, and AN+SG were given at dosages of 0.125, 0.25, and 0.5 mg/ egg. The hen's egg test for micronucleus induction (HET-MN) was performed in chick embryos to evaluate the genotoxic potential of the test agents. Furthermore, the cytotoxic potential was assessed by studying erythroblast cell populations and the polychromatic erythrocytes (PCEs) to normochromatic erythrocytes (NCEs) ratio. Our results indicated a significant increase (p < .001) in MN frequency and other nuclear abnormalities, suggesting the potential of AN and SG to cause genotoxicity. Also, AN and SG exposure alone and in combination considerably altered the erythroblast cell population (%) and the PCE to NCE ratio in all the treatment periods. Our findings established the genotoxic and cytotoxic potential of both AN and SG alone and in combination during early embryonic development in the chick embryo.

show abstract

Section: Discussionmentioning

confidence: 95%

Areca nut and smokeless tobacco exposure induces micronucleus, other nuclear abnormalities and cytotoxicity in early chick embryo

Mandal

Talukdar

Das

et al. 2023

Birth Defects Research

View full text Add to dashboard Cite

show abstract

“…The finding of cardiac anomalies, especially in isolated cases of EC, worsens the prognosis [12]. Differential diagnosis of ectopia cordis includes pentalogy of Cantrell, Beckwith-Wiedemann syndrome, amniotic band syndrome, and limb-body-wall complex [13].…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Array comparative genomic hybridisation in a foetus with thoracic ectopia cordis: a case report

Ghisu,

Gargiulo,

Sanna

et al. 2024

Ital J Gynaecol Obstet

View full text Add to dashboard Cite

Background. Ectopia cordis (EC) is a rare anomaly characterized by abnormal heart positioning. The exact etiology remains unknown, is likely to be associated with genetic and environmental factors. The introduction of an array-based comparative genomic hybridization (a-CGH) test has broadened our understanding of the genetic basis of many fetal anomalies, providing a more precise characterization of imbalances and allowing the comparison of the phenotype with other patients displaying imbalances in the same region. We report a rare case of ectopia cordis associated with the coexistence of a rare deletion in chromosome 19.Case presentation. A 28-year-old primigravida was referred to our hospital for abortion. Ultrasonography was performed to establish a gestational age of 17th weeks. A single fetus with isolated ectopia cordis with herniation of the heart from the right chest has been reported. The patient underwent therapeutic abortion. Anatomopathological examination of the fetus and whole genome a-CGH of the DNA of a flap of fetal skin was performed. Based on the cytogenetic analysis, the fetal karyotype was 46, XX. A-CGH analysis has detected a deletion of the short arm of chromosome 19 in the 19p13.3 band, containing the OMIM genes: TLE6-2-5, GNA11 and GNA15, S1PR4, and NCLN. Conclusions.The diagnosis of EC with sonography is important to identify the main defect and its associated abnormalities. There is no evidence that EC is a genetically transmitted disease, however, a-CGH analysis may be an excellent tool in providing adequate counselling for families.

show abstract

Ectopia cordis with multiple ventricular septal defect and sternal cleft in a newborn: a case report

Goli,

Majidi Balaneji,

Hosseinpour

et al. 2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Introduction and importance: Ectopia cordis is a rare type of malformation where the heart is not located normally. It may be partially or completely located outside the thoracic cavity and can be associated with other congenital abnormalities. Case presentation: This case report is of a 34-week- and 6-day-old female fetus with a birth weight of 2040 g, a height of 41 cm, and a head circumference of 32 cm. The initial physical examination revealed a responsive newborn with an externalized heart outside the chest, with pericardium protection. In addition, a thoracic wall defect was detected suggesting incomplete formation of the septum bone. Moreover, in this case, the echocardiography report showed a multiple ventricular septal defect. Conclusion: The management of ectopia cordis is a challenge for any obstetrician and pediatric surgeon due to its rarity. It causes mental agony and anxiety to the parents. With an early diagnosis, termination of pregnancy can be one of the options. Once it is diagnosed late, it needs a multidisciplinary approach, and the services of a very experienced pediatric surgeon to improve the prognosis.

show abstract

Ectopia Cordis as a Lethal Neonatal Condition: A Case Report from Bahrain and a Literature Review

Cited by 3 publications

References 29 publications

Areca nut and smokeless tobacco exposure induces micronucleus, other nuclear abnormalities and cytotoxicity in early chick embryo

Areca nut and smokeless tobacco exposure induces micronucleus, other nuclear abnormalities and cytotoxicity in early chick embryo

Array comparative genomic hybridisation in a foetus with thoracic ectopia cordis: a case report

Ectopia cordis with multiple ventricular septal defect and sternal cleft in a newborn: a case report

Contact Info

Product

Resources

About