Ectodermal abnormalities associated with methimazole intrauterine exposure

Martin-Denavit, Tanguy; Edery, Patrick; Plauchu, H; Attia‐Sobol, Jocelyne; Raudrant, D.; Aurand, Jill; Thomas, Laure

doi:10.1002/1096-8628(20001002)94:4<338::aid-ajmg13>3.0.co;2-6

Cited by 34 publications

(11 citation statements)

References 15 publications

(13 reference statements)

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“…The data are summarized in Table I. Arched eyebrows in patients 1 and 3 can also be observed in published photos from other MMI embryopathy cases [Greenberg, 1987; Wilson et al, 1998; Martin‐Denavit et al, 2000]. Thus, we suggest that this feature could be included in clinical MMI embryopathy pattern.…”

Section: Discussionsupporting

confidence: 69%

“…Other congenital defects associated with MMI prenatal exposure were described as follows: aplasia cutis congenita [Mujtaba and Burrow, 1975; Milham, 1985], esophageal atresia [Ramirez et al, 1992; Karlsson et al, 2002], nipples anomalies [Greenberg, 1987; Wilson et al, 1998], cardiovascular defects [Johnsson et al, 1997], hypospadias [Mujtaba and Burrow, 1975], and mental retardation [Greenberg, 1987; Wilson et al, 1998; Clementi et al, 1999]. An infant with aplasia cutis and other associated ectodermial anomalies (hyperpigmented, dry skin areas and dystrophic, small fingernails) was reported by Martin‐Denavit et al [2000].…”

Section: Discussionmentioning

confidence: 99%

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Choanal atresia associated with prenatal methimazole exposure: Three new patients

Barbero¹,

Ricagni²,

Mercado³

et al. 2004

American J of Med Genetics Pt A

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We report three patients with bilateral choanal atresia in children prenatally exposed to methimazole (MMI) in order to define a MMI embryopathy clinical pattern. The combination of choanal atresia and other specific malformations strongly resembles previously reported patients exposed to MMI in utero. At present, propylthiouracil is considered the best treatment in pregnancies. However in Argentina and some other countries MMI is the only antithyroid drug, possibly posing a significant risk to the unborn fetus.

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Choanal atresia associated with prenatal methimazole exposure: Three new patients

Barbero¹,

Ricagni²,

Mercado³

et al. 2004

American J of Med Genetics Pt A

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“…Martin‐Denavit et al [2000] described a 3‐year‐old girl with aplasia cutis of the scalp. She was normally grown with no palatal or cardiac abnormalities but had several other ectodermal abnormalities including areas of hyperpigmented skin on her trunk, two supernumerary nipples and dystrophic finger nails.…”

Section: Discussionmentioning

confidence: 99%

Carbimazole embryopathy: An emerging phenotype

Foulds¹,

Walpole²,

Elmslie³

et al. 2004

American J of Med Genetics Pt A

102

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Concerns about the safety of carbimazole in pregnancy were raised in 1985. Since this time many reports of children believed to have been affected by carbimazole in utero have appeared in the medical literature. Initial reports were of an increased incidence of scalp defects in the infants of treated mothers, but many other anomalies have now been described. Choanal atresia, gastrointestinal anomalies-particularly esophageal atresia, athelia/hypothelia, developmental delay, hearing loss, and dysmorphic facial features have all been reported. The phenotype associated with exposure to carbimazole appears to be rare but specific with distinctive facial features. We report on two new cases of carbimazole embryopathy with strikingly similar facial features.

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“…It induces skin changes in newborns of mothers treated with this drug during pregnancy (1,24,32). However, after local methimazole administration, a species-specific reaction to the is demonstrated.…”

Section: Discussionmentioning

confidence: 99%

“…This medicine has been known for more than 60 years and used in humans despite numerous side effects. The most often observed dermatological complications are aplasia cutis congenita and dystrophic fingernails in children born by mothers treated with methimazole during pregnancy (1,24,32), as well as drug-induced vasculitis (42). No side effects were observed in patients with local treatment of i.e.…”

Section: Introductionmentioning

confidence: 99%

Biophysical parameters of rats’ skin after the administration of methimazole

Gołyński¹,

Szczepanik²,

Lutnicki³

et al. 2014

Bulletin of the Veterinary Institute in Pulawy

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The paper describes the influence of oral administration of methimazole on biophysical skin parameters. Wistar rats of different sex (220-260 g) were used in the experiment. Biophysical skin parameters, such as transepidermal water loss (TEWL), corneometry, and pH were examined at seven-day intervals. Significant changes in the parameters were observed on the 7 th d of methimazole administration. The changes were observed in both sex but males appeared to be less sensitive in that respect. Changes in the parameters in the females showed rapid mechanisms, which normalised transepidermal water loss and skin hydration, as well as restored skin barrier functions. TEWL, skin hydration, and skin pH measurements allow an early assessment of skin barrier dysfunction after administration of this drug.

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Ectodermal abnormalities associated with methimazole intrauterine exposure

Cited by 34 publications

References 15 publications

Choanal atresia associated with prenatal methimazole exposure: Three new patients

Choanal atresia associated with prenatal methimazole exposure: Three new patients

Carbimazole embryopathy: An emerging phenotype

Biophysical parameters of rats’ skin after the administration of methimazole

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