Ecotoxicological screening of UV-filters using a battery of marine bioassays

Sanches, Matilde Vieira; Oliva, Matteo; Marchi, Lucia De; Cuccaro, Alessia; Puppi, Dario; Chiellini, Federica; Freitas, Rosa; Pretti, Carlo

doi:10.1016/j.envpol.2021.118011

Cited by 15 publications

(18 citation statements)

References 45 publications

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“…Some very useful model organisms within the 4-MBC research are molluscs (Mytilidae), American bullfrog (Lithobates catesbeianus), copepod (Tigriopus japonicus) and the freshwater caddisfly (Sericostoma vittatum). [46][47][48] Some other organisms involved in studying 4-MBC's effects are Japanese medaka (Oryzias latipes), Harlequin fly (C. riparius), zebrafish (Danio rerio), Senegalese sole (Solea Senegalensis) and Iberian green frog (Pelophylax perezi). The downside of many of these organisms, such as Japanese medaka and Harlequin fly, is that they are sensitive fish useful for ecotoxicity tests but less useful for studying 4-MBC's effects directly on human health.…”

Section: Discussionmentioning

confidence: 99%

The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression

Lax

Wicksell

Grip

et al. 2023

Basic Clin Pharma Tox

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4‐Methylbenzylidene camphor (4‐MBC) is a photo‐absorbing UV filter prevalently used in cosmetics, which can be absorbed into circulation and cause systemic effects. 4‐MBC is continued to be released in the environment despite the growing knowledge about its bioaccumulation and endocrine disrupting effects. Previous reviews have mentioned UV‐filter together but this review considers 4‐MBC alone, due to its prevalence and concerning health effects. This review considers 4‐MBC's potential effects on human health regarding systemic and molecular effects, with the main focus on reproduction. Also, the potential bioaccumulation and interactions with receptor systems such as the oestrogen receptors β and α, and progesterone receptor are covered. Additionally, previous studies about 4‐MBC's effects on mRNA and protein expression, especially in the prostate and the brain are analysed. Furthermore, 4‐MBC is reported to act with inflammatory pathways by activating p38 MAPK and NF‐κB, leading to the production of inflammatory TNF‐α and IL‐6. 4‐MBC was also found to induce apoptosis and inhibit cell proliferation and DNA repair. In conclusion, 4‐MBC has wide‐ranging effects in many different models interacting with multiple pathways causing long‐term effects even at low doses and this knowledge can guide governmental risk assessment, regulation divisions and chemical industries.

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Section: Discussionmentioning

confidence: 99%

The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression

Lax

Wicksell

Grip

et al. 2023

Basic Clin Pharma Tox

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“…Overall, proving the toxicity of NMs seems to have been the main concern among the retrieved studies. In this regard, most of the scientific articles test very high concentrations of NMs on organisms, targeting terrestrial and aquatic environments or both of them in order to find an ecotoxicological effect (e.g., 50% mortality—LC50; immobilization or growth inhibition—EC50 [ 21 , 41 , 64 , 65 , 66 ]). To date, most of the studies have used environmentally unrealistic concentrations to assess the NMs ecotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Nanomaterial Ecotoxicology in the Terrestrial and Aquatic Environment: A Systematic Review

Gambardella

Pinsino

2022

Toxics

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This systematic review analyzes the studies available on the ecotoxicity of nanomaterials (NMs) in the environment to understand where future research should be addressed for achieving Agenda 2030 goals on sustainable development and environmental safety. We discuss the status of NMs ecotoxicological effects across different organisms that are representative of all natural environments (land, air, water). A total of 1562 publications were retrieved from the Web of Science (all databases) by using the search criteria “nanomaterials” and “ecotoxicology”; among them, 303 studies were included in the systematic review because they met any of the following criteria: (i) focalize on both search criteria; (ii) deal with terrestrial, or aquatic environment; (iii) address models (organisms, cells) for the nano environmental risk assessment and exposure. The knowledge gaps are identified together with novel insights that need to be further investigated to better understand the ecotoxicological environmental impacts of NMs.

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“…Provedenim istraživanjem utvrđeno je da je najveća toksičnost n-TiO 2 na vrstu Phaeodactylum tricornutum (EC 50 = 0,043 mg l −1 ), dok na ostala dva organizma nije zamijećen štetan utjecaj. 50 Manje toksične su se pak pokazale n-ZnO za vrstu Phaeodactylum tricornutum (EC 50 = 4,55 mg l −1 ), no više za vrste Aliivibrio fischeri i Ficopomatus enigmaticus. Također je proveden test ekotoksičnosti n-ZnO na embrijima japanske orizija (Oryzias javanicus) i utvrđena je visoka akutna toksičnost u ultra-čistoj (LC 50 = 0,643 mg l −1 ), deioniziranoj (1,333 mg l −1 ) i dekloriranoj (2,370 mg l −1 ) vodi.…”

Section: Ispitivanje šTetnih Učinaka Anorganskih Uv Filtara Tio 2 I Znounclassified

SPF – super problematična formula? Aktivni sastojci krema za sunčanje u vodenom okolišu

Blažević¹,

Kos²,

Kovačević³

et al. 2023

Kemija U Industriji

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Ecotoxicological screening of UV-filters using a battery of marine bioassays

Cited by 15 publications

References 45 publications

The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression

The effect of sunscreen 4‐methylbenzylidene camphor in different and reproductive models, its bioaccumulation and molecular effects on ligand‐receptor interaction, and protein expression

Nanomaterial Ecotoxicology in the Terrestrial and Aquatic Environment: A Systematic Review

SPF – super problematična formula? Aktivni sastojci krema za sunčanje u vodenom okolišu

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