Ecotoxicological effects of a nonionic detergent (Triton DF-16) assayed by ModFETAX

Presutti, C.; Vismara, Claudio; Camatini, M; Bernardini, Giovanni

doi:10.1007/bf00197233

Cited by 16 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The developmental toxicity of MCPA was evaluated and compared with that of phenol and chlorocresol with a modified version of FETAX [3], a powerful and reliable bioassay that uses Xenopus embryos [13]. Thanks to its three end points (mortality, malformation, and growth inhibition), FETAX has been used for evaluating single compounds and/or their joint action [3,[14][15][16] as well as environmental mixtures [17] and the ecotoxicological efficiency of a water processing plant [18]. Nevertheless, FETAX can be useful for identifying potential human health hazards.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Developmental Toxicity of the Pesticide McPa and Its Contaminants Phenol and Chlorocresol

Bernardini¹,

Spinelli²,

Presutti³

et al. 1996

Environ Toxicol Chem

View full text Add to dashboard Cite

The embryotoxicity of 4-chloro-2-methylphenoxyacetic acid (MCPA), an extensively used herbicide, has been evaluated and compared to that of phenol and chlorocresol (two common contaminants) with a bioassay that makes use of embryos of the amphibian Xenopus. The MCPA-Na salt used in the bioassay was purified by crystallization and acid-base purification methods, and the concentrations of phenol and chlorocresol were checked by high-performance liquid chromotography. The relationship between the concentration of the tested molecule and the outcomes (i.e., mortality and malformations) was investigated using different models (probit, logit, and complementary log-log). The resulting LC50s for MCPA, chlorocresol, and phenol are 3,607, 13, and 178 mg/L, respectively; the resulting LC10s are 1,526, 6, and 32 mg/L. It is evident that the real MCPA toxicity can be masked by the presence of contaminants much more toxic than the molecule studied. Moreover, our results show that the three chemicals do not present a high teratogenic risk. Growth retardation shows that MCPA, chlorocresol, and phenol are effective at concentrations as low as 2,000, 2.5, and 25 mg/L, respectively. Keywords-EmbryotoxicTeratogen Herbicide Xenopus EmbryoEnviron. Toxicol. Chem. 15, 1996 G. Bernardini et al.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of the Developmental Toxicity of the Pesticide McPa and Its Contaminants Phenol and Chlorocresol

Bernardini¹,

Spinelli²,

Presutti³

et al. 1996

Environ Toxicol Chem

View full text Add to dashboard Cite

show abstract

“…Compared with the same tests on some species of Australian frogs X. laevis turned out to be more sensitive, and may be used to assess risks to wild species (Mann and Bidwell, 1999b). The FETAX procedure demonstrates that the anionic surfactant Triton DF-16 has an LC of 31 l/L and a TC of 10 l/L (Presutti et al, 1994), and, due to its similar values, this surfactant may be considered slightly teratogenic to X. laevis embryos. Delayed growth and reduced length were also reported in this case.…”

Section: Discussionmentioning

confidence: 94%

Teratogenic and Toxic Effects of Alcohol Ethoxylate and Alcohol Ethoxy Sulfate Surfactants on Xenopus laevis Embryos and Tadpoles

Cardellini

Ometto

2001

Ecotoxicology and Environmental Safety

View full text Add to dashboard Cite

“…Thanks to its three end points (mortality, malformation, and growth inhibition), FETAX has been used for evaluating single compounds and/or their joint action [3,[14][15][16] as well as environmental mixtures [17] and the ecotoxicological efficiency of a water processing plant [18]. Nevertheless, FETAX can be useful for identifying potential human health hazards.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of the developmental toxicity of the pesticide mcpa and its contaminants phenol and chlorocresol

Bernardini

Spinelli

Presutti

et al. 1996

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Abstract-The embryotoxicity of 4-chloro-2-methylphenoxyacetic acid (MCPA), an extensively used herbicide, has been evaluated and compared to that of phenol and chlorocresol (two common contaminants) with a bioassay that makes use of embryos of the amphibian Xenopus. The MCPA-Na salt used in the bioassay was purified by crystallization and acid-base purification methods, and the concentrations of phenol and chlorocresol were checked by high-performance liquid chromotography. The relationship between the concentration of the tested molecule and the outcomes (i.e., mortality and malformations) was investigated using different models (probit, logit, and complementary log-log). The resulting LC50s for MCPA, chlorocresol, and phenol are 3,607, 13, and 178 mg/L, respectively; the resulting LC10s are 1,526, 6, and 32 mg/L. It is evident that the real MCPA toxicity can be masked by the presence of contaminants much more toxic than the molecule studied. Moreover, our results show that the three chemicals do not present a high teratogenic risk. Growth retardation shows that MCPA, chlorocresol, and phenol are effective at concentrations as low as 2,000, 2.5, and 25 mg/L, respectively.

show abstract

Ecotoxicological effects of a nonionic detergent (Triton DF-16) assayed by ModFETAX

Cited by 16 publications

References 8 publications

Evaluation of the Developmental Toxicity of the Pesticide McPa and Its Contaminants Phenol and Chlorocresol

Evaluation of the Developmental Toxicity of the Pesticide McPa and Its Contaminants Phenol and Chlorocresol

Teratogenic and Toxic Effects of Alcohol Ethoxylate and Alcohol Ethoxy Sulfate Surfactants on Xenopus laevis Embryos and Tadpoles

Evaluation of the developmental toxicity of the pesticide mcpa and its contaminants phenol and chlorocresol

Contact Info

Product

Resources

About