Economic evaluation of seasonal influenza vaccination in elderly and health workers: A systematic review and meta-analysis

Dilokthornsakul, Piyameth; Lan, Le My; Thakkinstian, Ammarin; Hutubessy, Raymond; Lambach, Philipp; Chaiyakunapruk, Nathorn

doi:10.1016/j.eclinm.2022.101410

Cited by 17 publications

(18 citation statements)

References 36 publications

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“…A recent meta-analysis of the impact of vaccination on sickness absence confirms it is cost-effective to vaccinate HCWs. However, for patient nosocomial infection from HCWs, it concludes that little research is available specifically on how HCW vaccination protects patients and is eventually cost-effective [ 34 ]. Overall, most cost-effectiveness studies and reviews argue in favor of influenza vaccination in patients and HCWs [ 35 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Increasing Influenza Vaccination in Primary Healthcare Workers Using Solidary Incentives: Analysis of Efficacy and Costs

et al. 2023

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Introduction: Influenza vaccination campaigns have difficulty in reaching the 75% uptake in healthcare workers (HCWs) that public health organizations target. This study runs a campaign across 42 primary care centers (PCCs) where for every HCW vaccinated against influenza, a polio vaccine is donated through UNICEF for children in developing nations. It also analyses the efficacy and cost of the campaign. Method: This observational prospective non-randomized cohort study was conducted across 262 PCCs and 15.812 HCWs. A total of 42 PCCs were delivered the full campaign, 114 were used as the control group, and 106 were excluded. The vaccine uptake in HCWs within each of those PCCs was registered. The cost analysis assumes that campaign costs remain stable year to year, and the only added cost would be the polio vaccines (0.59€). Results: We found statistically significant differences between both groups. A total of 1423 (59.02%) HCWs got vaccinated in the intervention group and 3768 (55.76%) in the control group OR 1.14, CI 95% (1.04–1.26). In this scenario, each additional HCW vaccinated in the intervention group costs 10.67€. Assuming all 262 PCCs had joined the campaign and reached 59.02% uptake, the cost of running this incentive would have been 5506€. The potential cost of increasing uptake in HCWs by 1% across all PCC (n = 8816) would be 1683€, and across all healthcare providers, 8862€ (n = 83.226). Conclusions: This study reveals that influenza vaccination uptake can be innovative by including solidary incentives and be successful in increasing uptake in HCWs. The cost of running a campaign such as this one is low.

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Section: Discussionmentioning

confidence: 99%

Increasing Influenza Vaccination in Primary Healthcare Workers Using Solidary Incentives: Analysis of Efficacy and Costs

et al. 2023

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“…Cost-effectiveness studies conducted in LMICs evaluating influenza vaccinations in different populations have found that influenza vaccines are generally cost-effective [ 59 , 60 ]. Studies from high-income countries have also found that influenza vaccinations usually are cost-effective in diverse populations [ 61 , 62 , 63 , 64 , 65 ].…”

Section: Discussionmentioning

confidence: 99%

Influenza Vaccination Implementation in Sri Lanka: A Cost-Effectiveness Analysis

et al. 2023

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Influenza causes an estimated 3 to 5 million cases of severe illness annually, along with substantial morbidity and mortality, particularly in low- and middle-income countries (LMICs). Currently, Sri Lanka has no influenza vaccination policies and does not offer vaccination within the public healthcare sector. Therefore, we performed a cost-effectiveness analysis of influenza vaccine implementation for the Sri Lankan population. We designed a static Markov model that followed a population cohort of Sri Lankans in three age groups, 0–4, 5–64, and 65+ years, through two potential scenarios: trivalent inactivated vaccination (TIV) and no TIV across twelve-monthly cycles using a governmental perspective at the national level. We also performed probabilistic and one-way sensitivity analyses to identify influential variables and account for uncertainty. The vaccination model arm reduced influenza outcomes by 20,710 cases, 438 hospitalizations, and 20 deaths compared to no vaccination in one year. Universal vaccination became cost-effective at approximately 98.01% of Sri Lanka’s 2022 GDP per capita (incremental cost-effectiveness ratio = 874,890.55 Rs/DALY averted; 3624.84 USD/DALY averted). Results were most sensitive to the vaccine coverage in the 5–64-year-old age group, the cost of the influenza vaccine dose in the 5–64-years-old age group, vaccine effectiveness in the under-5-years-old age group, and the vaccine coverage in the under-5-years-old age group. No value for a variable within our estimated ranges resulted in ICERs above Rs. 1,300,000 (USD 5386.15) per DALY adverted. Providing influenza vaccines was considered highly cost-effective compared to no vaccines. However, large-scale national studies with improved data are needed to better inform estimates and determine the impact of vaccination implementation.

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“…But VCR need to reach the established targets and vaccines need to be selected based on demonstrated efficacy in preventing infection as well as in preventing complications attributable to influenza, such as cardiorespiratory hospitalizations or all cause hospitalizations, which may differ according to patient’s characteristics, and circulating strains [ 23 ]. For example, studies for the elderly population report that influenza vaccination is cost-effective regardless of the type of vaccine, but the magnitude of cost-effectiveness is higher in high-dose TIV and QIV than in standard-dose TIV [ 28 , 29 ]. We must ensure that the right vaccines are administered to the right at-risk population to achieve better protection, enabling higher cost savings to the NHS and lower health care resource utilization.…”

Section: What Are Our Proposed Actions?mentioning

confidence: 99%

Addressing influenza’s underestimated burden – Iberian experts call to action

et al. 2023

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Economic evaluation of seasonal influenza vaccination in elderly and health workers: A systematic review and meta-analysis

Cited by 17 publications

References 36 publications

Increasing Influenza Vaccination in Primary Healthcare Workers Using Solidary Incentives: Analysis of Efficacy and Costs

Increasing Influenza Vaccination in Primary Healthcare Workers Using Solidary Incentives: Analysis of Efficacy and Costs

Influenza Vaccination Implementation in Sri Lanka: A Cost-Effectiveness Analysis

Addressing influenza’s underestimated burden – Iberian experts call to action

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