Addressing influenza’s underestimated burden – Iberian experts call to action

Miguel, Ángel Gil de; Díez‐Domingo, Javier; Martinón‐Torres, Federico; Margüello, E. Redondo; Leonardo, Raúl Ortiz de Lejarazu; Pumarola, Tomás; Sousa, Jaime Correia de; Rabaçal, Carlos; Raposo, João Filipe; Cordeiro, Carlos Robalo; Froes, Filipe

doi:10.1186/s12879-023-08277-x

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BMC Infect Dis

2023

DOI: 10.1186/s12879-023-08277-x

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Addressing influenza’s underestimated burden – Iberian experts call to action

Ángel Gil de Miguel

Javier Díez‐Domingo

Federico Martinón‐Torres

et al.

Abstract: Having a proper understanding of the impact of influenza is a fundamental step towards improved preventive action. This paper reviews findings from the Burden of Acute Respiratory Infections study on the burden of influenza in Iberia, and its potential underestimation, and proposes specific measures to lessen influenza’s impact.

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2024

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Uncovering the burden of Influenza in children in Portugal, 2008–2018

Caldas Afonso,

Gouveia,

Januário

et al. 2024

BMC Infect Dis

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Background Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical and economic burden of severe influenza in children, in Portugal, during ten consecutive influenza seasons (2008/09-2017/18). Methods We reviewed hospitalizations in children aged < 5 years old using anonymized administrative data covering all public hospitals discharges in mainland Portugal. The burden of hospitalization and in-hospital mortality directly coded as due to influenza was supplemented by the indirect burden calculated from excess hospitalization and mortality (influenza-associated), estimated for four groups of diagnoses (pneumonia or influenza, respiratory, respiratory or cardiovascular, and all-cause), through cyclic regression models integrating the incidence of influenza. Means were reported excluding the H1N1pdm09 pandemic (2009/10). Results The mean annual number of hospitalizations coded as due to influenza was 189 (41.3 cases per 100,000 children aged < 5 years old). Hospitalization rates decreased with increasing age. Nine-in-ten children were previously healthy, but the presence of comorbidities increased with age. Children stayed, on average, 6.1 days at the hospital. Invasive mechanical ventilation was used in 2.4% of hospitalizations and non-invasive in 3.1%. Influenza-associated excess hospitalizations between 2008 and 2018 were estimated at 1,850 in pneumonia or influenza, 1,760 in respiratory, 1,787 in respiratory or cardiovascular, and 1,879 in all-cause models. A total of 95 influenza-associated excess deaths were estimated in all-cause, 14 in respiratory or cardiovascular, and 9 in respiratory models. Over ten years, influenza hospitalizations were estimated to have cost the National Health Service at least €2.9 million, of which 66.5% from healthy children. Conclusions Influenza viruses led to a high number of hospitalizations in children. Most were previously healthy. Results should lead to a reflection on the adequate preventive measures to protect this age group.

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Uncovering the burden of Influenza in children in Portugal, 2008–2018

Caldas Afonso,

Gouveia,

Januário

et al. 2024

BMC Infect Dis

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show abstract

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Addressing influenza’s underestimated burden – Iberian experts call to action

Cited by 1 publication

References 19 publications

Uncovering the burden of Influenza in children in Portugal, 2008–2018

Uncovering the burden of Influenza in children in Portugal, 2008–2018

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