Economic costs of the foot and mouth disease outbreak in the United Kingdom in 2001

Thompson, D.K.; Muriel, Priscilla; Russell, David; Osborne, Paulina; Bromley, A. M.; Rowland, M. G. M.; Creigh-Tyte, S.; Brown, Corrie C.

doi:10.20506/rst.21.3.1353

Cited by 382 publications

(237 citation statements)

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“…FMD (Sobrino and Domingo, 2004;Jamal and Belsham, 2013) affects livestock and is one of the economically most important animal diseases worldwide (Thompson et al, 2002;Paton et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Identification of the Structural Basis of Thermal Lability of a Virus Provides a Rationale for Improved Vaccines

et al. 2014

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Virus stability and dynamics play critical roles during infection. Some viruses, including foot-and-mouth disease virus (FMDV), are surprisingly prone to thermal dissociation outside the cell. The structural bases and functional implications of this distinctive trait were essentially unknown. This study (1) uncovers the structural determinants of FMDV thermolability, (2) investigates the relationship between virus thermolability and infectivity, and (3) provides a structure-based rationale for engineering thermostable virus particles to develop improved vaccines and nanocontainers. The results reveal that negatively charged residues close to protein-protein interfaces exert electrostatic repulsions between capsid subunits and mediate the sensitivity of the virion to thermal dissociation, even at neutral pH. Based on these results, a series of fully infectious virions of increased thermostability were engineered by individually removing different carboxylates involved in intersubunit repulsions. The implications for virus biology and the design of thermostable vaccines are discussed.

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“…FMD (Sobrino and Domingo, 2004;Jamal and Belsham, 2013) affects livestock and is one of the economically most important animal diseases worldwide (Thompson et al, 2002;Paton et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Identification of the Structural Basis of Thermal Lability of a Virus Provides a Rationale for Improved Vaccines

et al. 2014

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“…FMD is considered one of the most important livestock diseases in the world (Sutmoller and Casas Olascoaga, 2002) because of the severe socio-economic costs imposed on countries with the disease (Pluimers et al, 2002). FMD epidemics in previously free regions can have pronounced social, economic and political impacts (Chmitelin and Moutou, 2002;Pluimers et al, 2002) associated with control and eradication, as was experienced recently by the United Kingdom in 2001 (Thompson et al, 2002). While the USA has been FMD-free since 1929, models indicate that in a three-county region of California alone, partial direct costs associated with vaccination and depopulation could reach $ 551 million or more, depending on the number of herds involved (Bates et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Temporal and Spatial Distributions of Foot-and-Mouth Disease Under Three Different Strategies of Control and Eradication in Colombia (1982–2003)

2007

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Outbreaks of foot-and-mouth disease (FMD) from January 1982 through December 2003 were used to examine variations in serotype- and species-specific risk for three control programmes in Colombia: (1982-1983) vaccination, using an aluminium hydroxide, saponin adjuvant, required but not enforced; (1984-1996) vaccination, using an oil double-emulsion adjuvant, required but not enforced; and (1997-2003) enforced vaccination, using an oil double-emulsion adjuvant, restricted animal movement enforced, and slaughter of infected animals. Hypotheses were tested for trend, cyclicity and seasonality in FMD occurrence, and for species- and serotype-specific differences in morbidity and case-fatality. The spatial density of outbreaks was estimated by kernel smoothing. The frequency of outbreaks decreased most between 1984 and 1996 (p < 0.01) for serotype A and between 1997 and 2003 (p < 0.01) for serotype O. Outbreaks occurred in cycles of 3-4 years for both serotypes (p < 0.05). Morbidity was not significantly different in pigs from that in cattle for serotype A-associated outbreaks (p = 0.314), but was higher in pigs than in cattle (p = 0.019) for serotype O-associated outbreaks. For both serotypes, case-fatality was higher for pigs than for cattle (p < 0.009). Temporal variation in FMD incidence provided insight into the expected evolution of FMD control for countries with similar conditions and where FMD is endemic.

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“…Outbreaks can and do occur in these countries, however, with disastrous financial implications resulting from the trade sanctions imposed by the international community on the infected country. The 2001 FMD outbreak in the UK, for example, is estimated directly and indirectly to have cost US$12 billion (Thompson et al 2002). Even the "minor" FMD episode in the UK in 2007 may have cost at least US $500 million mainly in lost marketing opportunities (Jha 2007).…”

Section: The Importance Of Tadsmentioning

confidence: 99%

“…In-depth analyses of these issues: the economic costs of livestock diseases including TADs and of their control, and of the effects of these diseases on international trade are available (Thompson et al 2002;Perry et al 2004;Morgan and Prakash 2006;Tambi et al 2006).…”

Section: Indirect Lossesmentioning

confidence: 99%

Living with transboundary animal diseases (TADs)

Rossiter¹,

Hammadi²

2008

Trop Anim Health Prod

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Since the mid 1990s the term transboundary animal disease (TAD) has become widely used for a group of major infectious diseases of livestock with important economic impact. This article explains why the term is so appropriate and examines the severe direct and indirect consequences these diseases have when they cross borders. The paper also looks at the control of TADs and how improved control and trade can take place without having to eradicate them.

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Economic costs of the foot and mouth disease outbreak in the United Kingdom in 2001

Cited by 382 publications

References 0 publications

Identification of the Structural Basis of Thermal Lability of a Virus Provides a Rationale for Improved Vaccines

Identification of the Structural Basis of Thermal Lability of a Virus Provides a Rationale for Improved Vaccines

Temporal and Spatial Distributions of Foot-and-Mouth Disease Under Three Different Strategies of Control and Eradication in Colombia (1982–2003)

Living with transboundary animal diseases (TADs)

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