Economic cost of Guillain-Barré syndrome in the United States

Frenzen, Paul D.

doi:10.1212/01.wnl.0000316393.54258.d1

Cited by 79 publications

(46 citation statements)

References 20 publications

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“…This is not surprising given the severity of AFP, which often results in partial paresis to extensive paralysis that is often permanent, and similar high costs found with other conditions that can cause limb paralysis such as Guillain-Barré Syndrome. 9,20 Medical care costs, in particular the initial hospital costs, for case-patients with encephalitis were similar to that of AFP cases in our study and the costs for WNV encephalitis are similar to those previously published for other forms of encephalitis. 21 However, the lost productivity was notably lower for encephalitis cases because encephalitis tended to occur in older individuals who were retired at the time of their illness onset and thus incurred no lost productivity costs in our study.…”

Section: Discussionsupporting

confidence: 87%

Initial and Long-Term Costs of Patients Hospitalized with West Nile Virus Disease

Staples¹,

Shankar

Sejvar

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. There are no published data on the economic burden for specific West Nile virus (WNV) clinical syndromes (i.e., fever, meningitis, encephalitis, and acute flaccid paralysis [AFP]). We estimated initial hospital and lost-productivity costs from 80 patients hospitalized with WNV disease in Colorado during 2003; 38 of these patients were followed for 5 years to determine long-term medical and lost-productivity costs. Initial costs were highest for patients with AFP (median $25,117; range $5,385-$283,381) and encephalitis (median $20,105; range $3,965-$324,167). Long-term costs were highest for patients with AFP (median $22,628; range $624-$439,945) and meningitis (median $10,556; range $0-$260,748). Extrapolating from this small cohort to national surveillance data, we estimated the total cumulative costs of reported WNV hospitalized cases from 1999 through 2012 to be $778 million (95% confidence interval $673 million-$1.01 billion). These estimates can be used in assessing the cost-effectiveness of interventions to prevent WNV disease.

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Section: Discussionsupporting

confidence: 87%

Initial and Long-Term Costs of Patients Hospitalized with West Nile Virus Disease

Staples¹,

Shankar

Sejvar

et al. 2014

The American Society of Tropical Medicine and Hygiene

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“…However, considering the severity of the symptoms and the potential high costs of care for GBS patients [42,] even an only slight increase in GBS incidences should be avoided. In vaccine safety monitoring, which plays an important role for public health because it might strongly influence the acceptance of certain vaccines, GBS is regularly monitored as a potential adverse effect.…”

Section: Discussionmentioning

confidence: 99%

Estimation of Background Incidence Rates of Guillain-Barré Syndrome in Germany - A Retrospective Cohort Study with Electronic Healthcare Data

Hense

Schink²,

Kreisel³

et al. 2014

Neuroepidemiology

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Background: The Guillain-Barré syndrome (GBS) occurs after infections and as an adverse reaction to vaccines. No detailed information on incidence rates (IRs) in Germany is available. Methods: This retrospective cohort study estimated age- and sex-specific IRs of GBS in Germany in the years 2007-2009 based on electronic healthcare data from the German Pharmacoepidemiological Research Database (GePaRD). Two case definitions were applied. GBS cases had a main discharge diagnosis of GBS. GBS_PROCEDURE cases in addition had codes for relevant diagnostic procedures. Crude and standardized IRs (SIRs) with 95% confidence intervals were stratified by year, age group, sex, region and season. IR ratios (IRRs) for each stratification factor were calculated by multivariable Poisson regression. Results: Among 13,297,678 persons, 889 (693) incident GBS (GBS_PROCEDURE) cases were identified. Overall SIRs per 100,000 person years were 2.4 (2.2-2.5) for GBS and 1.8 (1.7-2.0) for GBS_PROCEDURE. (S)IRs increased with age, peaking in the age group 70-79 years (IR GBS: 5.5 (4.7-6.5)) and were higher in males than in females (e.g., IR GBS: IRR = 1.5 (1.3-1.7)) and in February-April, as compared to the rest of the year. No regional pattern was observed. Conclusion: (S)IRs of GBS in Germany differed by age, sex and season and were comparable to those found in other studies. Results might be used as a comparator in vaccine safety monitoring.

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“…The most important and most common is Guillain Barre syndrome, since the disappearance of polio in 2000 in Bangladesh, a high incidence of acute flaccid weakness in Bangladeshi children (3.25 cases per 100,000) is still present but is now related mostly to GBS. Frequent exposure to enteric pathogens at an early age may increase this incidence of GBS [2].…”

Section: Introductionmentioning

confidence: 99%

“…Campylobacter jejuni seems to be the most commonly described pathogen associated with GBS. Occasionally, surgery has been noted to be a precipitating factor, and venom snake has been reported too [2].…”

Section: Introductionmentioning

confidence: 99%

Study of acute flaccid paralysis surveillance system in Kerman (Iran) for one decade

Ebrahimi¹,

Nakhaee²,

Zahmatkesh³

et al. 2014

RusOMJ

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Background -During the past decade, polio eradication has stalled globally. Acute flaccid paralysis (AFP) surveillance is a key strategy for monitoring the progress of polio eradication. All AFP patients who referred to expert committee were evaluated about the causes. Methods -This case series study is the result of activities for one decade of expert AFP committee of Kerman University of Medical Sciences from 2002-2011, with coverage of more than 2,650,000 populations and 730,677 child with age of ≤15 years old. All patients have gone under diagnostic and therapeutic managements. Results -The total cases referred to Kerman expert committee of AFP for ten years were 147 cases. In our study the incidence of AFP was 2.016 per 100000 populations for one year.The most common causes of AFP were Guillain-Barre syndrome (GBS). Other causes of AFP were; stroke, synovitis, myelitis, seizures, cerebral palsy, viral infections, tumors, cerebellitis and non-polio AFP. The rate of GBS in our study was 0.96 per 100000 in children 15 years old or smaller, and more in male. In this study the incidence rate in cities with low mean temperature was higher than in cities with high mean temperature. Conclusion -We had no polio case in this period. The most common cause of AFPs was Guillain-Barre syndrome. The incidence of GBS was higher in areas with low mean temperature.

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Economic cost of Guillain-Barré syndrome in the United States

Cited by 79 publications

References 20 publications

Initial and Long-Term Costs of Patients Hospitalized with West Nile Virus Disease

Initial and Long-Term Costs of Patients Hospitalized with West Nile Virus Disease

Estimation of Background Incidence Rates of Guillain-Barré Syndrome in Germany - A Retrospective Cohort Study with Electronic Healthcare Data

Study of acute flaccid paralysis surveillance system in Kerman (Iran) for one decade

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