Economic burden of varicella in children 1–12 years of age in Argentina, 2009–2014

Giglio, Norberto; Monsanto, H; Rampakakis, Emmanouil; Yang, Huili; Kuter, Barbara J.; Wolfson, Lara J.

doi:10.1080/13696998.2018.1431919

Cited by 17 publications

(33 citation statements)

References 32 publications

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“…Five published studies reported data on the complications associated with varicella in LAC (see Additional file 3). Three studies provided data for Brazil [31, 32, 45] and one study each for Argentina [26] and Uruguay [15].…”

Section: Resultsmentioning

confidence: 99%

“…Among hospital inpatients aged 1–12 years with varicella in a study in Argentina, 99% had at least one complication, most commonly skin or soft tissue infection, pneumonia, sepsis, cerebellitis, and febrile seizure; by comparison, 28% of outpatients aged 1–12 years with varicella had one or more complications [26]. In a university hospital study in Brazil, 60% of inpatients with varicella had associated complications, most commonly bacterial skin infection (47%) and respiratory (4%), renal (3%), and central nervous system (2%) complications [32].…”

Section: Resultsmentioning

confidence: 99%

“…In total, eight published studies provided evidence for the economic impact of varicella in the LAC region, with data from Argentina [26], Brazil [28, 31–33], Colombia [37], Costa Rica [22], and Uruguay [15].…”

Section: Resultsmentioning

confidence: 99%

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Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review

et al. 2019

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Background Varicella is typically mild and self-limiting, but can be associated with complications and even death. The limited data available on varicella in Latin America and the Caribbean (LAC) indicate substantial burden in countries where varicella vaccine is not part of publicly funded childhood national immunization programs. Methods A systematic literature review of published studies was complemented by “gray” literature on varicella incidence, complications, mortality, and economic consequences, in the absence and presence of universal varicella vaccination (UVV) in LAC. Results Seroprevalence data indicate that varicella is usually a disease of childhood in LAC. Varicella incidence rates, while unreliable in the absence of mandatory reporting, show a trend to increased incidence due to greater urbanization and population density. The introduction of UVV in national immunization programs has led to significant reductions in varicella incidence in these areas. Conclusions Varicella continues to pose a substantial healthcare burden in LAC. The future introduction of UVV in additional countries is predicted to provide substantial reductions in cases, with important economic benefits. For countries that have already implemented UVV, the challenge is to maintain high rates of coverage and, where relevant, consider inclusion of a second dose to reduce breakthrough cases. Given the significant proportion of the region now implementing UVV, a regional recommendation in order to prevent any potential for age-shifts in varicella infection might be considered. Electronic supplementary material The online version of this article (10.1186/s12889-019-6795-0) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review

et al. 2019

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“…They were excluded because: concerned costs on vaccine and vaccination programs [1]; concerned cost of chickenpox and of complications but not specifically AC-HAP [4]; reported only clinical data [1]. In literature the HAP for varicella may vary, depending on the study, ranging from 600 dollars to 4583 dollars per person, depending on the study [12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?

et al. 2020

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Background: Chickenpox is a highly contagious airborne disease caused by the varicella zoster virus. It is generally benign and self-limiting, but it may be responsible of life-threatening complications. Acute cerebellitis (AC) is the most common neurological complication and is associated with prolonged hospitalization in the acute phase (HAP). Aim of the study: To estimate the costs of AC HAP in children affected by varicella. Materials and methods: We retrospectively reviewed the medical records of a pediatric cohort hospitalized for chickenpox AC over a period of 15 years (from October 2003 to October 2018) and we analyzed acute care costs. For any patient the HAP has been calculated. The final value includes cost of hospital accommodation and management at the Pediatric and Infectious Diseases Unit. To this cost, the price of procedures (imaging, laboratory exams, medical and paramedical evaluations) and medical treatments was added. Results: In the study period, 856 children had been hospitalized for varicella. Out of them, 65 met a diagnosis of AC and were included in the study. The hospitalization length was of 10 days (range 3-20 days). The median cost of HAP for each patient was of 5366 euro, with an average annual cost of 23,252 €. The most significant part of HAP is due to the cost of hospital accommodation and management at the Pediatric Infectious Diseases Unit, which was about € 537.78 for a single day. Discussion: Although AC post-varicella is rare, its HAP cost is not negligible resulting in substantial economic burden. Vaccination would have probably prevented varicella and AC complication, avoiding hospitalization. Conclusions: Financial studies are important for evaluate the cost saving in order to influence public funding decisions. Further studies are necessary to investigate the economic burden of the disease.

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“…Recent studies report a significant clinical, resource, and economic burden associated with varicella in countries where UVV programs have not been implemented, such as Poland, Argentina, and Hungary. [73][74][75] Occurrence of complications and the need for hospitalizations placed demand on health-care resources (e.g., need for medications, tests/diagnoses, health-professional consultations) as well as having an indirect economic impact (e.g., time taken off work to look after children). [73][74][75] Although data on the impact of varicella vaccination in the Middle East are limited, the data that are available indicate that the UVV has the potential to substantially reduce the clinical burden of the disease.…”

Section: Rationale Supporting Varicella Vaccination Decision-making Imentioning

confidence: 99%

The clinical and economic burden of varicella in the Middle East: a systematic literature review

Kaabi

Olama

Qaseer

et al. 2019

Human Vaccines & Immunotherapeutics

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This systematic literature review was conducted to better understand the epidemiology and burden of varicella across the Middle East, gain insight into the evidence to support using universal varicella vaccination (UVV), and identify potential data gaps. Both epidemiology and economic data on the burden of varicella were limited and varied significantly. Most of the data focussed on varicella burden in the absence of a UVV program. In the absence of UVV, varicella incidence is increasing across this region with varicella infection associated with substantial morbidity. Although limited, data on the impact of vaccination at a population level indicated UVV programs reduce varicella incidence and hospitalizations, in line with global experience. Further research and action are needed to better understand varicella epidemiology in the Middle East, increase awareness and understanding in the region, and provide local data to support national public-health decisions regarding the implementation of UVV programs. ARTICLE HISTORY

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Economic burden of varicella in children 1–12 years of age in Argentina, 2009–2014

Abstract: The clinical burden of varicella in Argentina was associated with utilization of significant amounts of healthcare resources, resulting in substantial economic costs. These costs should be reduced with the recent implementation of routine vaccination of children.

Cited by 17 publications

References 32 publications

Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review

Burden of varicella in Latin America and the Caribbean: findings from a systematic literature review

Hospitalization for acute cerebellitis in children affected by varicella: how much does it cost?

The clinical and economic burden of varicella in the Middle East: a systematic literature review

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