Economic Burden of Surgically Confirmed Endometriosis in Canada

Levy, Adrian R.; Osenenko, Katherine M.; Lozano‐Ortega, Greta; Sambrook, Robert; Jeddi, Mark; Bélisle, Serge; Reid, Robert L.

doi:10.1016/s1701-2163(16)34986-6

Cited by 73 publications

(47 citation statements)

References 14 publications

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“…Endometriosis constitutes one of the greatest gynecological issues of our days, as it affects up to 10 % of the general population [1] and is a significant burden on the quality of life for women with the disease [2,3]. A large portion of the patients with endometriosis ends up being treated with surgery.…”

Section: Discussionmentioning

confidence: 99%

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Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review

Zorbas

Economopoulos

Vlahos

2015

Arch Gynecol Obstet

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Section: Discussionmentioning

confidence: 99%

“…The clinical manifestation of endometriosis is composed of the following three entities: (1) infertility, (2) pelvic mass, and (3) pelvic pain. Pelvic pain can be further characterized as dyspareunia, dysmenorrhea, and chronic pelvic pain.…”

mentioning

confidence: 99%

Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review

Zorbas

Economopoulos

Vlahos

2015

Arch Gynecol Obstet

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“…Endometriosis affects 6-10% of reproductive-aged women. Despite its staggering economic impact ($1.8 Billion/year in Canada [1]; $22 Billion/year in the USA [2]), endometriosis remains misdiagnosed, misunderstood and ineffectively treated. The cause of this enigmatic disease is unknown; however, the theory of retrograde menstruation is widely accepted.…”

Section: Introductionmentioning

confidence: 99%

Implications of immune dysfunction on endometriosis associated infertility

et al. 2016

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Endometriosis is a complex, inflammatory disease that affects 6-10% of reproductive-aged women. Almost half of the women with endometriosis experience infertility. Despite the excessive prevalence, the pathogenesis of endometriosis and its associated infertility is unknown and a cure is not available. While many theories have been suggested to link endometriosis and infertility, a consensus among investigators has not emerged. In this extensive review of the literature as well as research from our laboratory, we provide potential insights into the role of immune dysfunction in endometriosis associated infertility. We discuss the implication of the peritoneal inflammatory microenvironment on various factors that contribute to infertility such as hormonal imbalance, oxidative stress and how these could further lead to poor oocyte, sperm and embryo quality, impaired receptivity of the endometrium and implantation failure.

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“…The average in-patient medical cost for laparoscopic intervention in 2004 was $3,721 vs $4,300 in 2007 [10,11]. This cost increased dramatically for patients whom had hysterectomies, which are performed on almost 20% of patients who have endometriosis, to $11,400 in 2007.…”

Section: Economic Impactmentioning

confidence: 99%

“…Upon further evaluation and results from imaging or laboratory tests, the patient may be referred to a gynecologist or may simply be advised to begin non-steroidal antiinflammatory drugs (NSAIDS) or oral contraception pills (OCPs). The diagnostic work up and decision of treatment options differs depending if a patient who has endometriosis is under the medical care of a general practitioner or a gynecologist [11]. Patients under the medical care of a gynecologist are more likely to undergo exploratory laparoscopic surgery and excisional removal of lesions followed by endocrine disruptors such as GnRH antagonists than those patients seen by a general practitioner.…”

Section: Delay To Diagnosismentioning

confidence: 99%

What Does Diagnosis of Endometriosis Mean? The Patient′s Perspective

Braundmeier¹,

Lenz²,

Fazleabas³

2016

JFIV Reprod Med Genet

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Endometriosis is a gynecological disease, which causes significant physiological pain but also psychological distress leading to decreased quality of life for those afflicted with the disease. Though researchers have investigated this disease for over 90 years, there is still much information unknown about its pathophysiology, hence impeding the development of effective treatment options. In addition, the difficulty to diagnose the disease using non-invasive measures increases the prevalence of this disease among reproductive aged women. This review discusses the challenges that the scientific and medical communities endure combating endometriosis along with the social and financial burdens of patients whom suffer from endometriosis. Finally this review highlights the positive and negative side effects of current treatment options, discusses some alternative treatment and new potential treatment options that have shown variable success in reducing the symptoms associated with endometriosis.

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Economic Burden of Surgically Confirmed Endometriosis in Canada

Cited by 73 publications

References 14 publications

Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review

Continuous versus cyclic oral contraceptives for the treatment of endometriosis: a systematic review

Implications of immune dysfunction on endometriosis associated infertility

What Does Diagnosis of Endometriosis Mean? The Patient′s Perspective

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