Economic and social aspects of pituitary dwarfism treatment with recombinant growth hormone

Воронцова, М. В.; Нагаева, Е. В.; Найговзина, Н. Б.

doi:10.14341/probl201763282-91

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Проведенный М.В. Воронцовой медико-экономический анализ различных аспектов лечения детей с гипофизарным нанизмом доказал, что терапия детей в рамках государственной программы высокозатратных нозологий является клинически и экономически эффективной [ 33 ][ 34 ].…”

Section: стг-дефицит у детейunclassified

Growth hormone — 30 years of clinical practice: past, present, future

Dedov,

Bezlepkina,

Pankratova

et al. 2024

Probl Endokrinol (Mosk)

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The recombinant technologies era, which began in the second half of the XX century, made it possible to produce recombinant growth hormone (rGH) necessary for the treatment of stunting of various genesis. The time of practically unlimited possibilities of rGH production has come, which served as a stimulus for studying the efficacy and safety of rGH application, searching for optimal ways of its use and dosing regimes. Many years of experience in the use of somatropin in clinical practice allowed us to obtain data on its effectiveness primarily in somatotropic insufficiency in children, to study its effect on the functional state of various organs and systems, and to expand the indications for the use of RGR.

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Section: стг-дефицит у детейunclassified

Growth hormone — 30 years of clinical practice: past, present, future

Dedov,

Bezlepkina,

Pankratova

et al. 2024

Probl Endokrinol (Mosk)

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“…Dwarfism can be defined as a standing height more than two standard deviations below the average or below the 3rd percentile (for sex and age) [1–3]. Achondroplasia and growth hormone deficiency (GHD) are responsible for the majority of children dwarfism cases.…”

Section: Introductionmentioning

confidence: 99%

Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism

Zhou¹,

2019

Ital J Pediatr

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BackgroundCombined simultaneous arginine clonidine stimulation (CSACS) test represents a more appropriate stimulus to detect Ghrelin, for it does not affect glucose metabolism.MethodsFifty prepubertal children with dwarfism were recruited and further classified into normal growth hormone (NGH) and growth hormone deficiency (GHD) group with growth hormone (GH) peak cut-off value of 10 μg/l. In both groups, GH and Ghrelin serum levels were determined after the GH provocation test at 30, 60, and 120 min and the height standard deviation score (SDS) for bone age was measured six months later.ResultsThe participants were classified into NGH (n = 24) and GHD group (n = 26). A decrease in the circulating Ghrelin levels prior to the GH peak was observed in the NGH children, whereas both GH and Ghrelin levels demonstrated a rise in the GHD children. Ghrelin level in GHD group was higher compared with NGH group and the GH peak in GHD group is lower than NGH group. The 6 months CSACS treatment could increase the height SDS in both groups.ConclusionAlthough analogous changes were not detected in GHD group, the inverse correlation between GH and Ghrelin in NGH indicates a negative feedback lying between GH and Ghrelin.

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Hypopituitarism in children and adolescents

Воронцова

2019

Med. sov.

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Growth is one of the most important indicators of child health. This article focuses on hypopituitarism, an endocrine disease with isolated growth hormone deficiency (somatotropic hormone) or multiple deficiency of the pituitary tropic hormones. The authors describe the etiology, genetic mechanisms of the disease development and provide the classification. The clinical picture and its variants, the diagnostic search are described in detail, and the criteria of referral to the endocrinologist are given. A separate chapter is devoted to the detailed discussion of stimulation samples, criteria for samples selection and scheduling. The authors also raise an issue of retesting. The scheme of treatment of hypopituitarism in accordance with domestic and foreign standards is provided. A list of necessary examinations in the framework of observation of a child with hypopituitarism is given.

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Economic and social aspects of pituitary dwarfism treatment with recombinant growth hormone

Cited by 3 publications

References 12 publications

Growth hormone — 30 years of clinical practice: past, present, future

Growth hormone — 30 years of clinical practice: past, present, future

Dynamic Ghrelin and GH serum levels during combined simultaneous arginine clonidine stimulation test in children with dwarfism

Hypopituitarism in children and adolescents

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