Economic and disease burden of RSV-associated hospitalizations in young children in France, from 2010 through 2018

Abstract

Background Respiratory syncytial virus (RSV) is the main cause of infant and child hospitalizations. The study objective is to estimate the RSV-associated hospitalizations and economic burden in young children in France to inform future preventive strategies. Methods We conducted a retrospective analysis of RSV-associated hospitalizations data from the French Hospital database (PMSI-MCO) which covers the entire French population. All children aged < 5 years hospitalized with RSV ICD-10 codes (J210, J219, J45, J121, J205, R062) from 2010 to 2018, were included. Descriptive analyses were conducted by RSV seasons (Oct to March), by respiratory years (July to June) and per age groups. Results On average 45,225 RSV-associated hospitalizations (range: 43,715 – 54,616) per season was reported in France, 69% among children < 1 year old. This represents 28% of all-cause hospitalizations that occurred among children < 1 year old, and less than 10% of all-cause hospitalizations in older children. Number of RSV-associated hospitalizations were similar for infants born during (Oct-March) or outside (April–September) their first RSV season. The highest risk being reported for infants born from September through November. The associated hospitalization cost increased between 2010 - 11 and 2017–18, from €93.2 million to €124.1 million, respectively, and infants < 1 year old represented 80% of the economic burden. Conclusion RSV is an important cause of child hospitalization in France. The burden on healthcare system is mainly driven by < 1 year olds, and preventive strategies should be implemented before the first RSV season.

Respiratory syncytial virus-associated hospitalisation in children aged ≤5 years: a scoping review of literature from 2009 to 2021

“…A French study by D emont et al . (2021) [ 17 ] investigating the economic burden of RSV hospitalisations found that incidence of RSV hospitalisations in under 5s increased from 21.96 to 28.8 per 1000 infant-years between 2010 and 2018. However, the absence of an increased number of RSV cases during the 2020 season is likely attributable to external factors, such as the SARS-CoV-2 pandemic and subsequent behavioural and sociological shifts due to NPIs.…”

“…D emont et al . (2021) [ 17 ] found that the most burdened age group in terms of RSV hospitalisation was aged <1 year, representing 69% of hospitalisations. Incidence of RSV hospitalisations in this population increased from 0.52 to 0.74 per 1000 infant-years between 2010 and 2018 and was significantly higher than in other age groups.…”

Expected Impact of Universal Immunization With Nirsevimab Against RSV-Related Outcomes and Costs Among All US Infants in Their First RSV Season: A Static Model

“…Despite lower hospitalization rates, the number of hospitalizations in the oldest age groups (ie, infants born outside the season) was almost equivalent to those in the youngest infants born within the season. This modelled RSV hospitalization distribution pattern was validated through 2 real-world studies in France and the United Kingdom [ 39 , 40 ]. The RSV burden in infants born outside the season can be explained by a longer duration of exposure to RSV.…”

Respiratory Syncytial Virus: Knowledge, Attitudes and Beliefs of General Practitioners from North-Eastern Italy (2021)

“…Human RSV is associated with a substantial burden of disease in children and elders [ 7 , 10 , 35 , 38 , 42 , 50 , 51 ]. NPI, due to the SARS-CoV-2 pandemic, have led to the substantial disappearance of the conventional seasonal trend for RSV infections [ 1 , 24 , 29 , 30 , 31 , 52 , 53 , 54 , 55 , 56 , 57 ], that have been in turn followed by an unprecedented surge in incident cases [ 29 , 30 , 31 , 52 , 58 , 59 ].…”