Economic analysis of vaccination to control bovine brucellosis in the States of Sao Paulo and Mato Grosso, Brazil

Alves, Ana Julia Silva e; Rocha, Felipe; Amaku, Marcos; Ferreira, Fernando; Telles, Evelise Oliveira; Grisi-Filho, José Henrique Hildebrand; Neto, José Soares Ferreira; Zylbersztajn, Décio; Dias, Ricardo Augusto

doi:10.1016/j.prevetmed.2014.12.010

Cited by 26 publications

(22 citation statements)

References 9 publications

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“…Brucellosis is a highly contagious zoonotic disease caused by Brucella spp and poses great challenges to public health, particularly in developing countries 1 2. It is rarely fatal, but has important impacts on the livestock economy due to loss of production in international markets 3. Human brucellosis is commonly transmitted from infected livestock directly or indirectly, and is characterised by acute febrile illness, inflammation of the genitals, sterility, spontaneous miscarriage and lymphatic system lesions, amounting to more than half a million new cases annually worldwide 4.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological features of human brucellosis in Tongliao City, Inner Mongolia province, China: a cross-sectional study over an 11-year period (2007–2017)

Zhai³

et al. 2020

BMJ Open

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ObjectivesTo describe the epidemiology of human brucellosis in the past decade and provide evidence of disease control in Tongliao city, which is one of the highest-risk areas of human brucellosis in Inner Mongolia province, China.DesignCross-sectional study.ParticipantsClinically and bacteriologically confirmed human brucellosis cases.Primary and secondary outcome measuresAn analysis of the reported cases of human brucellosis during 2007–2017 was carried out to describe the age, sex and occupational distributions of the cases. The time series analysis model and the geographical information system were explored to describe the seasonality and spatiotemporal distribution, respectively, at the county level.ResultsA total of 13 938 cases of human brucellosis was collected in Tongliao from 2007 to 2017; the majority was aged 25 years to 59 years (85.4%) and the male-to-female ratio was 2.64:1; most of them were agriculturalists (81.9%) and pastoralists (12.4%). The incidence rates increased dramatically from 9.22/100 000 in 2007 to 69.16/100 000 in 2011 with an annual increase of 14.99%. They decreased during 2012–2016 (annual decrease of 8.37%) and rose again in 2017 (44.32/100 000). The disease peaked during March–July, with a clear periodicity and trend of monthly anterior displacement since 2012. Jarud Banner, the region located in the north-west of Tongliao, had the highest accumulated incidence rate (130.1/100 000) compared with other counties. The high-risk regions were spread from the north-west to the south and east of Tongliao during the past decade.ConclusionsThe prevalence of human brucellosis in Tongliao was aggravated during the past decade and peaked during March–July. High-risk areas were mainly concentrated in the counties with extensive prairies and livestock.

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Section: Introductionmentioning

confidence: 99%

Epidemiological features of human brucellosis in Tongliao City, Inner Mongolia province, China: a cross-sectional study over an 11-year period (2007–2017)

Zhai³

et al. 2020

BMJ Open

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“…Bovine brucellosis is widespread and is of major importance due to its impact on both animal and human health (Alves et al., ). According to the World Health Organization estimates, approximately 400,000 people become infected yearly from Brucella by a foodborne route, with almost half of the cases appearing in the Eastern Mediterranean Region (World Health Organization, ).…”

Section: Introductionmentioning

confidence: 99%

Characterization and evolution of countries affected by bovine brucellosis (1996–2014)

Cárdenas

Awada

Tizzani

et al. 2019

Transbound Emerg Dis

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This paper describes the global distribution and temporal evolution of bovine brucellosis due to Brucella abortus during a 19‐year period (1996–2014) using the information officially reported to the World Organisation for Animal Health (OIE) by veterinary services of 156 countries. Variables that can influence the health status of bovine brucellosis (i.e., year, per capita Gross Domestic Product (GDP), continent and bovine population) were also analysed. Countries were classified into three categories of health situations: ENZOOTIC: countries infected, which may have been free of brucellosis but for periods of fewer than 3 years; NON‐ENZOOTIC: countries where the disease was present but that had at least a 3‐year period without the disease; and FREE: countries where the disease remained absent during the whole period. The countries free from bovine brucellosis, or in the process of eradication, were located in Oceania and Europe, while the more affected regions were Central and South America, Africa and parts of Asia. Among the Non‐Enzootic countries, the results showed that a very high proportion managed to control the disease during the period of study, with a sharp decline in the percentage of infected countries from 71% in 1996 to 10% in 2014. Among the Enzootic countries, a much smaller proportion managed to control the disease, with a slight drop in the percentage of infected countries from 92% in 1996 to 80% in 2014. A relationship was found between the status of the disease and the availability of economic resources; thus, countries with a high GDP per capita tended to be free from bovine brucellosis. On the other hand, countries with a larger bovine population showed a greater probability to have the disease present. An increase in surveillance programmes and implementation of control policies were observed during the period of study.

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“…The current study was oriented on analysis of the economic losses occurring due to brucellosis in small ruminants in Iraq. This analysis focused on impacts arising from loss of pregnancy and reduced milk yield, as these have been reported to be among the most significant outcomes of infection [ 11 , 27 ]. In this study, we populated the cost–benefit analysis model based on integrated data from our previous research on brucellosis in small ruminants in the study area; key model parameters were informed based on a recent cohort study [ 17 ] and a former cross-sectional serological survey carried out by our group in Dohuk [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

Cost–Benefit Analysis of a Mass Vaccination Strategy to Control Brucellosis in Sheep and Goats in Northern Iraq

et al. 2021

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Brucellosis is a major economic and production-limiting disease for livestock owners and the community in Iraq. A cost–benefit analysis was conducted to evaluate the impact of an expanded annual mass vaccination programme of sheep and goats that involves all female and male sheep and goats over the age of 3 months with Rev. 1 vaccine. The proposed expanded vaccination programme was compared to the current annual vaccination program, which involved only vaccinating female sheep and goats between the ages of 3 and 6 months of age with Rev. 1. The cost-benefit analysis model was developed utilizing data collected in Dohuk Governorate, northern Iraq. The seroprevalence in small ruminants (using Rose Bengal test and ELISA in series) was predicted to decrease from 9.22% to 0.73% after 20 years of implementing the proposed annual mass vaccination program. The net present value of the mass vaccination program was estimated to be US$ 10,564,828 (95% Confidence Interval (CI): −16,203,454 to 37,049,245), the benefit–cost ratio was estimated to be 4.25 (95% CI: −2.71 to 11.22), and the internal rate of return was 91.38% (95% CI:11.71 to 190.62%). The proposed vaccination strategy was predicted to decrease the overall financial loss caused by brucellosis from 1.75 to 0.55 US$ per adult female animal. The results of this economic analysis highlight the benefit of implementing an annual mass vaccination program of small ruminants with Rev. 1 vaccine to reduce the prevalence of brucellosis in northern Iraq.

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Economic analysis of vaccination to control bovine brucellosis in the States of Sao Paulo and Mato Grosso, Brazil

Cited by 26 publications

References 9 publications

Epidemiological features of human brucellosis in Tongliao City, Inner Mongolia province, China: a cross-sectional study over an 11-year period (2007–2017)

Epidemiological features of human brucellosis in Tongliao City, Inner Mongolia province, China: a cross-sectional study over an 11-year period (2007–2017)

Characterization and evolution of countries affected by bovine brucellosis (1996–2014)

Cost–Benefit Analysis of a Mass Vaccination Strategy to Control Brucellosis in Sheep and Goats in Northern Iraq

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