Laboratory tests give us information on the presence of disease, the activity of inflammatory disorders, the presence of some bacteria and viruses, the functions of the organ systems, the success of therapy and the changes in it after therapy, as well as the side effects of therapy. A reference laboratory is a medical laboratory with procedures followed in a specified environment and particular conditions for the purpose of preparing reference materials, reagents, or kits to be used in laboratory tests or for providing quality control materials in results of measurements or conformity assessments made in laboratories or by organizations. It is necessary to mention that throughout these processes while preparing reference materials, reagents, or kits from the envelope till the process is finished certified products must have been done with recommended quality norms. Reference laboratories are mainly established for a significant role in health services, and they have primary designations to develop a high level of service quality in the health care system.