Ecological risk assessment of pesticides on soil biota: An integrated field-modelling approach

Mu, Hongyu; Yang, Xiaomei; Wang, Kai; Tang, Darrell; Xu, Wen; Liu, Xuejun; Ritsema, C.J.; Geissen, Violette

doi:10.1016/j.chemosphere.2023.138428

Cited by 13 publications

(3 citation statements)

References 38 publications

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“…Excessive applications of IMI can cause severe contamination of water and soil in the environment, 50,51 damage the immune system of nontarget organisms, and cause apoptosis and mitochondrial dysfunction. 52,53 Birds have the potential to encounter IMI through multiple means, including seeds, soil, water, and insects, and IMI can cause oxidative stress in their organisms.…”

Section: Discussionmentioning

confidence: 99%

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway

Wang,

Sun,

et al. 2023

Environmental Toxicology

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Imidacloprid (IMI) is a neonicotinoid insecticide with the highest global market share, and IMI exposure in the environment can negatively affect many nontarget organisms (a general term for organisms affected by drugs other than target organisms). Resveratrol (RSV), a non‐flavonoid polyphenolic organic compound derived from peanuts, grapes, and other plants, has anti‐inflammatory and antioxidant effects. It is currently unclear how RSV protects against cell damage caused by IMI. Therefore, we established an experimental model of chicken lymphocyte lines exposed to 110 μg/mL IMI and/or 0.5 μM RSV for 24 h. According to the experimental results, IMI markedly raised intracellular reactive oxygen species levels and diminished the activity of the cellular antioxidant enzymes (CAT, SOD, and GPx), leading to MDA accumulation and decreased T‐AOC. JNK, ERK, and P38, the essential components of the mitogen‐activated protein kinase (MAPK) signaling pathway, were also expressed more when IMI was present. Additionally, IMI resulted in upregulation of mitochondrial apoptosis (Caspase 3, Caspase 9, Bax, and Cyt‐c) and necroptosis (Caspase 8, RIPK1, RIPK3, and MLKL) related factors expression, downregulation of Bcl‐2 expression, induction of upregulation of cytokine IL‐6 and TNF‐α expression, and downregulation of IFN‐γ expression. The combined treatment of RSV and IMI significantly reduced cellular oxidative stress levels, inhibited the MAPK signaling pathway, and alleviated IMI‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction. To summarize, RSV antagonized IMI‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway

Wang,

Sun,

et al. 2023

Environmental Toxicology

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“…[8][9][10] For industrial chemicals, agrochemicals, medicines, cosmetics, food additives, and food contact compounds, environmental risk assessment (ERA) is the foundation of regulatory decisions. [11][12] Many physiochemical parameters, ecotoxicology, and environmental fate studies are frequently used for this purpose. [13][14] Water solubility, adsorption to soil and sediments, volatilization, biotic and abiotic degradation, and bioaccumulation are all factors that affect a chemical's environmental fate and behavior.…”

Section: Introductionmentioning

confidence: 99%

“…Ecotoxicological risk assessment aims to provide a comprehensive understanding of the nature, extent, and probability of a chemical ′ s possible harmful effects on health and the environment [8–10] . For industrial chemicals, agrochemicals, medicines, cosmetics, food additives, and food contact compounds, environmental risk assessment (ERA) is the foundation of regulatory decisions [11–12] . Many physiochemical parameters, ecotoxicology, and environmental fate studies are frequently used for this purpose [13–14] .…”

Section: Introductionmentioning

confidence: 99%

Predictionof Environmental FateandToxicityofInsecticidesUsing Multi‐Target QSAR Approach

Pandey

2023

Chemistry & Biodiversity

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Ecotoxicological risk assessments form the foundation of regulatory decisions for industrial chemicals used in various sectors. In this study, a multi‐target‐QSAR model established by a backpropagation neural network trained with the Levenberg‐Marquardt (LM) algorithm was used to construct a statistically robust and easily interpretable Mt‐QSAR model with high external predictability for the simultaneous prediction of the environmental fate in form of octanol‐water partition coefficient (LogP), (BCF) and acute oral toxicity in mammals and birds (LD50rat) and (LD50bird) for a wide range of chemical structural classes of insecticides. Principal component analysis was performed on descriptors selected by the SW‐MLR method, and the selected PCs were used for constructing the SW‐MLR‐PCA‐ANN model. The developed well‐trained model (RMSE=0.83, MPE=0.004, CCC=0.82, IIC=0.78, R2=0.69) was statistically robust as indicated by the external validation parameters (RMSE=0.93, MPE=0.008, CCC=0.77, IIC=0.68, R2=0.61). The AD of the developed Mt‐QSAR model was also defined to identify the most reliable predictions. Finally, the missing values in the dataset for the aforementioned targets were predicted using the constructed Mt‐QSAR model. The proposed approach can be used for simultaneous prediction of the environmental fate of new insecticides, especially ones that haven′t been tested yet.

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Highly sensitive electrochemical quantification of carbendazim via synergistic enhancement of ring-opening metathesis polymerization and polyethyleneimine modified graphene oxide

Xue,

Jia,

et al. 2024

Microchim Acta

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Ecological risk assessment of pesticides on soil biota: An integrated field-modelling approach

Cited by 13 publications

References 38 publications

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway

Resveratrol alleviates imidacloprid‐induced mitochondrial apoptosis, necroptosis, and immune dysfunction in chicken lymphocyte lines by inhibiting the ROS/MAPK signaling pathway

Predictionof Environmental FateandToxicityofInsecticidesUsing Multi‐Target QSAR Approach

Highly sensitive electrochemical quantification of carbendazim via synergistic enhancement of ring-opening metathesis polymerization and polyethyleneimine modified graphene oxide

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