Ecological and epidemiological data on Hantavirus in bank vole populations in Belgium

Verhagen, Ron; Leirs, Herwig; Ткаченко, Е. А.; Groen, G van der

doi:10.1007/bf01314280

Cited by 51 publications

(42 citation statements)

References 17 publications

(9 reference statements)

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“…Several hypotheses, not necessarily mutually exclusive, may be suggested to explain the patterns of maturation and survival we have described. In bank voles, the probability of acquiring PUUV infection has been found to increase with a proxy of age (body weight; Verhagen et al, 1986;Olsson et al, 2002). Hence, within the group of reproductively inactive bank voles, PUUV IgG-positive individuals might be older and, consequently, more likely to mature, or to die, in the near future.…”

Section: Discussionmentioning

confidence: 99%

Impact of Puumala Virus Infection on Maturation and Survival in Bank Voles: A Capture-Mark-Recapture Analysis

Tersago

Crespin

Verhagen

et al. 2012

Journal of Wildlife Diseases

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ABSTRACT:Many zoonotic diseases are caused by rodent-borne viruses. Major fluctuations in the transmission of these viruses have been related to large changes in reservoir host population numbers due to external factors. However, the impact of the pathogen itself on the demography of its reservoir host is often overlooked. We investigated the impact of Puumala virus (PUUV) on survival and reproductive maturation probability of its reservoir host, the bank vole (Myodes glareolus). Three years (2004-06) of data from nine independent sites in southern Belgium were collected and analyzed with a capture-mark-recapture (CMR) method that includes statistical correction for the variation in capture probability of voles. A multistate model based on four states of reproductive activity and PUUV immunoglobulin G (IgG) antibody status was used to estimate survival and probability of transition from one reproductive or infection state to another. Although survival estimates for reproductively active voles were similar between infected and noninfected individuals, PUUV infection in reproductively inactive voles decreased mean monthly survival by 14%. PUUV infection was associated with a threefold increase in the probability of reproductive maturation in bank voles. Moreover, the probability of PUUV IgG seroconversion was three times higher for reproductively active voles compared to reproductively inactive voles. Our model indicates that PUUV infection may alter bank vole population dynamics by affecting both survival and maturation in its host. Additional studies, using CMR methodology with shorter time intervals between trapping sessions and possibly a longer duration, are needed to confirm these findings.

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Section: Discussionmentioning

confidence: 99%

Impact of Puumala Virus Infection on Maturation and Survival in Bank Voles: A Capture-Mark-Recapture Analysis

Tersago

Crespin

Verhagen

et al. 2012

Journal of Wildlife Diseases

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“…These site-specific differences in bank vole dynamics probably reflect crucial attributes of the case sites (Hansson, 1990(Hansson, , 1999Lö fgren, 1995;). The population dynamics of bank voles and occurrence of PUU virus have previously been shown to be spatially heterogeneous at regional and local scales (Verhagen et al, 1986;Escutenaire et al, 2000). Because the pattern was consistent over time in the present study, these results emphasize the importance and relevance of identifying habitat features that are likely to be associated with increased risks of exposure to hantavirus.…”

Section: Discussionmentioning

confidence: 99%

Hantavirus Antibody Occurrence in Bank Voles (Clethrionomys Glareolus) During a Vole Population Cycle

Olsson

Ahlm

Elgh

et al. 2003

Journal of Wildlife Diseases

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Puumala virus, genus Hantavirus, is the etiologic agent of nephropathia epidemica, a mild form of hemorrhagic fever with renal syndrome. The bank vole (Clethrionomys glareolus) is the natural reservoir species of this hantavirus. We initiated sampling of bank voles at sites of recently identified human nephropathia epidemica cases and paired control sites in the fall of 1995 in coastal areas of northern Sweden. Sites were trapped annually in spring and fall until 1999. Prevalence of antibody to Puumala virus was similar among local bank vole populations in the two types of sites over time. During peak years, however, the absolute number of bank voles was higher in case sites than control sites. Consequently, the likelihood of Puumala virus exposure was increased at case sites during population highs. This would imply that the risk of Puumala virus exposure to conspecifics and humans is habitat and site dependent with a temporal component.

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“…Hantaviral antigens were detected by using enzyme-linked immunosorbent assay (ELISA)-antigen capture as described elsewhere (Verhagen et al, 1986). Briefly, 10% lung suspensions were added to microtiter plates containing affinity-purified anti-PUU virus IgG from convalescent sera, with immunofluorescent antibody (IFA) titers not less than 16,000.…”

Section: Antigen Detectionmentioning

confidence: 99%

Genetic similarity of Puumala viruses found in Finland and western Siberia and of the mitochondrial DNA of their rodent hosts suggests a common evolutionary origin

Dekonenko

Yakimenko

Ivanov

et al. 2003

Infection, Genetics and Evolution

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Ecological and epidemiological data on Hantavirus in bank vole populations in Belgium

Cited by 51 publications

References 17 publications

Impact of Puumala Virus Infection on Maturation and Survival in Bank Voles: A Capture-Mark-Recapture Analysis

Impact of Puumala Virus Infection on Maturation and Survival in Bank Voles: A Capture-Mark-Recapture Analysis

Hantavirus Antibody Occurrence in Bank Voles (Clethrionomys Glareolus) During a Vole Population Cycle

Genetic similarity of Puumala viruses found in Finland and western Siberia and of the mitochondrial DNA of their rodent hosts suggests a common evolutionary origin

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