Ecofriendly Validated Spectrophotometric Method for the Estimation of Amlodipine Besylate by using Hydrotropic Solubilization Method

Waghmare, Akshay; Taware, Ganesh; Baokar, Shrikrishna; Undare, Santosh

doi:10.5958/2231-5675.2019.00003.6

Cited by 9 publications

(2 citation statements)

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“…Mefenamic acid as an individual from the anthranilic acid class or fenamates class of nonsteroidal anti-inflammatory drugs used in the treatment of gentle to direct pain and irritation in rheumatic illnesses, osteoarthritis, intense pain like muscle and back pain, toothache, and in menorrhagia. It acts by inhibiting both isoforms of the enzyme cyclooxygenase inhibitors and also focuses on the arrangement of prostaglandins that assume a part in pain affectability and aggravation, fever, additionally in hemostasis, kidney work, pregnancy, and in the assurance of the gastric mucosa [1][2][3][4][5]. As for bioavailability of the BCS Class II drugs, the solubility and dissolution rate are always the rate-determining step and as for mefenamic acid.…”

Section: Introductionmentioning

confidence: 99%

Analytical Applications of Mefenamic Acid by Hydrotrope Approach: Titrimetric Estimation and Ultraviolet Method Validation

Tripathi

Sharma

Sahoo

2021

Asian J Pharm Clin Res

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Objectives: Mefenamic acid is used as a modal nonsteroidal anti-inflammatory drug for analytical estimation. Due to the poor aqueous solubility, mefenamic acid liberated reduced bioavailability. Methods: The hydrotropic solubilization technique is a promising technique used to improve the solubility of water-insoluble drugs. Experimentally, 2 M sodium benzoate has been employed in the prior titrimetric estimation of mefenamic acid and shows synergistic enhancement in the solubility of mefenamic acid by many folds as compared to the distilled water. Similarly, sodium benzoate approach was further applied in analytical estimation of marketed oral dosage forms in tablets, capsules, and suspension for checking the reproducibility of applied approach by ultraviolet (UV) method. Validation of UV method was further done and checked for linearity, accuracy, and precision. Drug degradation studies were also performed successfully to investigate the sustainability of mefenamic acid in various dosage forms under various stress conditions and to establish the preferred storage conditions for the drug. Results: In the present experimental investigation, obtained mean % recoveries were close to 100 indicating the accuracy of the proposed approach. Similarly, in analytical estimation of mefenamic acid in oral marketed forms, results have reported lower values of standard deviation, % coefficient of variation, and standard error facilitated the reproducibility and precision of the proposed approach in the titrimetric estimation and analytical validation of UV method mefenamic acid in bulk and marketed forms. Conclusion: Therefore, a new, simple, precise, and inexpensive proposed method was executed by validating the result statistically.

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Section: Introductionmentioning

confidence: 99%

Analytical Applications of Mefenamic Acid by Hydrotrope Approach: Titrimetric Estimation and Ultraviolet Method Validation

Tripathi

Sharma

Sahoo

2021

Asian J Pharm Clin Res

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“…Many UV spectrophotometric methods are reported for other drugs in literature. [8][9][10][11][12][13][14][15][16][17][18][19]…”

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confidence: 99%

Validated First-Order Derivative Ultraviolet Spectrophotometric Determination of Rebamipide in Pharmaceutical Products

S R,

et al. 2023

IJPQA

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A very simple, accurate, precise, and reproducible process has been established for the estimation of rebamipide in pharmaceuticals. The literature review suggested that no UV method for quantitative estimation of first-order derivative for the rebamipide, accordingly a method has been developed and reported. As per the need for design a novel approach to analyze the drug utilizing dimethyl formamide as a solvent was identified. Rebamipide has absorbance maxima for first order derivative 314 nm. Rebamipide drug follows Beer’s law in a range of concentration between 20 to 200 μg/mL. The recovery studies verified the proposed method’s accuracy and findings were validated in accordance with ICH recommendations. The findings were deemed to be reliable and satisfactory. As a result, the suggested method can be used to quantitatively estimate Rebamipide in ordinary analysis work

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A Review of Hydrotropic Solubilization Techniques for Enhancing the Bioavailability of Poorly Soluble Drugs

Sharma,

Saroha

2023

Int J Toxicol

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Hydrotropic solubilization is a technique that can be used to improve the solubility of drugs that are poorly soluble. This technique involves adding a large amount of a second solute, known as a hydrotrope, which increases the aqueous solubility of the poorly soluble drug. Hydrotropes such as sodium citrate, sodium benzoate, and urea have been shown to be effective in enhancing the solubility of poorly soluble drugs. This technique has several advantages over other solubility enhancement techniques, including its cost-effectiveness, eco-friendliness, and the fact that it does not require chemical modification of hydrophobic drugs or the use of organic solvents. Hydrotropic agents are now being used to develop various dosage forms, including solid dispersions, mouth-dissolving tablets, and injections, to improve poorly water-soluble drugs' therapeutic effectiveness and bioavailability. This review paper will provide an overview of hydrotropic solubilization techniques.

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Ecofriendly Validated Spectrophotometric Method for the Estimation of Amlodipine Besylate by using Hydrotropic Solubilization Method

Cited by 9 publications

References 0 publications

Analytical Applications of Mefenamic Acid by Hydrotrope Approach: Titrimetric Estimation and Ultraviolet Method Validation

Analytical Applications of Mefenamic Acid by Hydrotrope Approach: Titrimetric Estimation and Ultraviolet Method Validation

Validated First-Order Derivative Ultraviolet Spectrophotometric Determination of Rebamipide in Pharmaceutical Products

A Review of Hydrotropic Solubilization Techniques for Enhancing the Bioavailability of Poorly Soluble Drugs

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