Validated First-Order Derivative Ultraviolet Spectrophotometric Determination of Rebamipide in Pharmaceutical Products

Abstract

A very simple, accurate, precise, and reproducible process has been established for the estimation of rebamipide in pharmaceuticals. The literature review suggested that no UV method for quantitative estimation of first-order derivative for the rebamipide, accordingly a method has been developed and reported. As per the need for design a novel approach to analyze the drug utilizing dimethyl formamide as a solvent was identified. Rebamipide has absorbance maxima for first order derivative 314 nm. Rebamipide drug follows Beer’s law in a range of concentration between 20 to 200 μg/mL. The recovery studies verified the proposed method’s accuracy and findings were validated in accordance with ICH recommendations. The findings were deemed to be reliable and satisfactory. As a result, the suggested method can be used to quantitatively estimate Rebamipide in ordinary analysis work