Ecofriendly Synthesis of Ribociclib Intermediate Using Regioselective Hydrodechlorination and DMAP Catalyzed Ester Hydrolysis

Green chemical principles based regioselective functionalization of 2,4,6-trichloropyrimidine-5-carbaldehyde: Application in the synthesis of new pyrimidines and pyrrolopyrimidine

“…25 As shown in Table III, the best conversion of the reaction from 9 to 10 was achieved with Na2CO3 in 1,4-dioxane at 110 o C. It was observed that inorganic bases were more effective in obtaining better cyclization conditions instead of organic base diisopropylethylamine (DIPEA). 26 After finalizing the conversion, compound 10 was purified using column chromatography. Compound 10 was characterized based on 1 H NMR by the appearance of cyclized five-membered ring alkene proton signal at δ = 7.4 ppm, in addition to that the appearance of its mass peaks at m/z 314 over mass chromatogram with a dichloro mass pattern in positive scan mode.…”

Synthesis, Crystal Structure, and Analysis of Hirshfeld Surface of Hexa (4‐Aminopyridine) Triscopper(II) Carbonate Trihydrate

“…[32] According to the spectrum data, derivatives of 4-aminopyridine structures were synthesized and indicate those derivatives are potentially highly active with some medicinal importance in the future. [33][34][35] Transition metals are important tools and are analyzed to develop molecule drug development interactions. [36][37][38] Due to their great affinity with electrons, reactivity, and shape, transition metals are employed to generate medications that are effective against cancer.…”