Green chemical principles based regioselective functionalization of 2,4,6-trichloropyrimidine-5-carbaldehyde: Application in the synthesis of new pyrimidines and pyrrolopyrimidine
Abstract:The present work reports the synthesis of three new nitrogen-containing
heteronuclear molecules (two pyrimidines and one pyrrolopyrimidine). Based
on the 12 principles of green chemistry, chemical methodologies are planned
and executed. Various phase transfer catalysts were examined in the crucial
step to execute C-N bond formation (through SnAr mechanism), TBAI was found
to be a better option than that of TBand CTAB. The one-pot synthetic
methodology was optimized involving Wittig olefinatio… Show more
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