Ecofriendly synthesis, antimicrobial and antispermatogenic activity of triorganotin(IV) complexes with 4′‐nitrobenzanilide semicarbazone and 4′‐nitrobezanilide thiosemicarbazone

Abstract

New series of triorganotin(IV) complexes with 4 -nitrobenzanilide semicarbazone (L 1 H) and 4 -nitrobenzanilide thiosemicarbazone (L 2 H) of the type [R 3 Sn(L)] (R = -CH 3 , -C 6 H 5 and n-C 4 H 9 ) were synthesized under microwave irradiation. All the complexes were characterized by elemental analysis, conductance measurements, molecular weight determinations and spectral data, viz., IR, UV-vis, 1 H, 13 C and 119 Sn NMR. The central tin atoms of these complexes are all five-coordinated with trigonal bipyramidal geometry. In order to assess their growth inhibitory potency semicarbazone, thiosemicarbazone and their triorganotin(IV) complexes were tested in vitro against some pathogenic fungi and bacteria. Also the ligands and their organotin(IV) complexes were studied to assess the effects of long-term ingestion of these compounds on fertility, body and reproductive organ weights. The biochemical analyses were also performed on blood samples and reproductive organs of male rats. The findings have been presented in this paper.

Diorganotin(IV) Complexes with Monohydrate Disodium Salt of Iminodiacetic Acid: Synthesis, Characterization, Crystal Structure and Biological Activities

“…Both the organotin(IV) complexes displayed comparatively less antimicrobial activities as compared to the standard drugs streptomycin and fluconazole. It was clarified that biological (antibacterial/antifungal) activities of the organotin(IV) derivatives 1-2 were varied depending upon the substitution pattern [29][30][31] at tin and also the nature of microbial strains; the metal bound with alkyl/aryl moieties play a key role in this regard. The inhibitory action of organotin(IV) compounds is mainly due to their ability to interact with DNA and protein.…”

Chloridodiphenyl{[1-(1,3-thiazol-2-yl-κN)ethylidene]-4-phenylthiosemicarbazidato-κ2N1,S}tin(IV) methanol monosolvate

“…For the biological activity and structural characteristics of tin compounds of thiosemicarbazones, see: Teoh et al (1999); Gielen et al (2005); Chaudhary et al (2009); Bamgboye & Bamgboye (1988); Barberi et al (1993); Casas et al (1994Casas et al ( , 1996Casas et al ( , 1997; De Sousa et al (2001); Li et al (2011); Macias et al (1989); Huheey et al (1993). For related structures, see: Venkatraman et al (2004Venkatraman et al ( , 2007Venkatraman et al ( , 2009; Swesi et al (2006a,b,c); Sreekanth & Kurup (2004); Mendes et al (2008); Li et al (2011).…”

Synthesis, characterization, antimicrobial, and DNA cleavage evaluation of some organotin(IV) complexes derived from ligands containing the 1H-indole-2,3-dione moiety

“…Organotin(IV) compounds possess cytotoxic and antitumor activities (Ahmad et al, 2007). Semicarbazones (Sharma et al, 2010) and thiosemicarbazones (Kapoor et al, 2011) are biologically important nitrogen and oxygen/sulfur donor ligands, and their organotin(IV) complexes show significant activity (Chaudhary et al, 2009).…”