Eco-friendly green synthesis of silver nanoparticles from the sesame oil cake and its potential anticancer and antimicrobial activities

Purpose: The present study synthesized silver nanoparticles (AgNPs) using the aqueous extract of a traditional medicinal product consisting of an oleoresin (a combination of macromolecules of carbohydrates and proteins) exuded from the rhizome of the plant Ferula foetida (asafoetida gum) and evaluated its biological properties. Materials and Methods: The silver nanoparticles synthesized using asafoetida gum (As-AgNPs) were characterized using UV/Vis spectroscopy, fourier infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and transmission electron microscopy (TEM) and EADX. The cytotoxicity and antimicrobial activity As-AgNPs were evaluated against MCF-7 cell lines and selected microbial pathogens, respectively. Results: The synthesized silver nanoparticles were crystalline in nature with a spherical shape. The average particle size was 5.6-8.6 nm. The cytotoxicity of the synthesized As-AgNPs was evaluated against MCF-7 cell lines, and the As-AgNPs were found to be effective in inhibiting the multiplication of cancer cells. The As-AgNPs exhibited significant antimicrobial activity towards E. coli, K. pneumoniae and C. albicans. The MIC of the synthesized As-AgNPs was 7.80 μg/mL for E. coli ATCC 25922, Salmonella sp. WS50-and S. typhi; 15.60 μg/mL for S. typhimurium and S. aureus WS10, and 31.20 μg/mL for K. pneumoniae and S. aureus ATCC 43300-MRSA. In addition, MIC values of 15.60 μg/mL for C. albicans ATCC8436 and 31.20 μg/mL for C. krusei ATCC6258 were obtained. Conclusion: As asafoetida is a good traditional medicine, its involvement in the synthesis of AgNPs led the silver nanoparticles to exhibit good cytotoxic and antimicrobial effects.

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“…In addition, SEM and EDS analyses were performed in our earlier studies to determine the size and element distribution. [18][19][20]…”

Section: Agnp Size and Shape Measurementsmentioning

confidence: 99%

<p>Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum</p>

Devanesan

Karuppiah

AlSalhi

et al. 2020

IJN

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“…A lot of research and development has already been performed on it, but still there is a need for developing a more powerful drug against SA. 14,15 In medicinal applications, AgNPs have prime importance as they are considered a candidate drug-delivery substance. The principle mechanism is based on the penetration of AgNPs in the cell wall and distresses the cell respiration.…”

Section: Introductionmentioning

confidence: 99%

“…19 Nano-silver's unique physical and chemical properties make it highly bioactive such that it can react with cells, microorganisms and macro-organisms. 14,20,21 The present work is based on a green synthesis of AgNPs using extracts of neem leaves (NE) alone and a mixture of neem, onion and tomato (NOT) at different pHs: pH 5, pH 7 and pH 9. The synthesized AgNPs were characterized by different techniques, such as UV-vis, XRD, Zetasizer, AFM, SEM and TEM.…”

Section: Introductionmentioning

confidence: 99%

Green synthesis characterization and antimicrobial activity againstStaphylococcus aureusof silver nanoparticles using extracts of neem, onion and tomato

et al. 2019

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“…AlSalhi e colaboradores (2019) avaliaram a atividade antiproliferativa das AgNPs frente às células de linhagem de câncer de mama (MCF-7), obtendo resultados de citotoxicidade promissores com valor de IC 50 de 42,19 AgNPs parecem atuar frente às células tumorais com citotoxicidade dosagem dependente, mostrando serem nanopartículas promissoras no tratamento de alguns cânceres (Gomaa, 2017;AlSalhi et al, 2019;Alfuraydi et al, 2019).…”

Section: Atividade Antitumoral Das Agnpsunclassified

A Importância Da Atenção Farmacêutica Frente as Principais Interações Medicamentosas E Alimentares

Silva¹,

Siqueira²

2020

Farmácia E Promoção Da Saúde 5

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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Eco-friendly green synthesis of silver nanoparticles from the sesame oil cake and its potential anticancer and antimicrobial activities

Cited by 127 publications

References 30 publications

<p>Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum</p>

<p>Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum</p>

Green synthesis characterization and antimicrobial activity againstStaphylococcus aureusof silver nanoparticles using extracts of neem, onion and tomato

A Importância Da Atenção Farmacêutica Frente as Principais Interações Medicamentosas E Alimentares

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