Eco-friendly biosynthesis and characterization of silver nanoparticles using Tinospora cordifolia (Thunb.) Miers and evaluate its antibacterial, antioxidant potential

Selvam, Kandasamy; Sudhakar, Chinnappan; Govarthanan, Muthusamy; Thiyagarajan, P.; Sudalai, Arumugam; Balakrishnan, Senthilkumar; Selvankumar, Thangasamy

doi:10.1016/j.jrras.2016.02.005

Cited by 104 publications

(38 citation statements)

References 31 publications

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“…The model was stronger and predicted a better response as R 2 was closer to 1.000. In previous studies, a regression model with R 2 > 0.9000 has been considered to have a very high correlation [23]. The CV was calculated to be 12.41 and 9.26 % for R1 and R2, respectively, and was found to be satisfactory (▶ Tables 1 and 2).…”

Section: Resultsmentioning

confidence: 93%

Increased Oral Bioavailability of Piperine from an Optimized Piper nigrum Nanosuspension

et al. 2018

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The aim of the present study was to enhance the pharmaceutical potential and oral bioavailability of piperine, which is the bioactive constituent of Piper nigrum, using the nanosuspension approach. Nanoprecipitation, which is a simple and reproducible process, was used for nanosuspension formulation. To prepare a pharmaceutical-grade nanosuspension with the required particle size, important formulation parameters (amount of plant extract, concentration of stabilizer, and antisolvent-to-solvent ratio) were optimized using the central composite design of response surface methodology. The optimized nanosuspension was characterized using scanning electron microscopy, atomic force microscopy, Fourier transform infrared spectroscopy, and in vitro dissolution testing as well as by measuring the zeta potential. In vivo pharmacokinetic studies were conducted to determine the bioavailability of the prepared nanosuspension. Results of the optimization study indicated that 0.13% plant extract, 0.25% stabilizer, and an antisolvent-to-solvent ratio of 10.0 were the best parameters to obtain a homogeneous nanosuspension with the required particle size. The optimized nanosuspension demonstrated a mean particle size, polydispersity index, and zeta potential of 172.5 nm, 0.241, and − 16.6 mV, respectively. The results of the characterization studies illustrated that the nanosuspension was in the nanometer size range and had good surface morphology. The optimized nanosuspension showed a better dissolution rate and a 3.65-fold higher oral bioavailability for the P. nigrum nanosuspension than its coarse suspension. The present outcomes clearly demonstrated that to obtain an effective therapeutic potential, nanoformulation of medicinal plants is a better alternative than conventional dosage forms.

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Section: Resultsmentioning

confidence: 93%

Increased Oral Bioavailability of Piperine from an Optimized Piper nigrum Nanosuspension

et al. 2018

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“…7,8 Biological methods are ecofriendly and non-toxic to the environment; these approaches include using metabolites as stabilizing and capping agents. [9][10][11] Among the three methods, biological methods have advantages over conventional methods, which involve chemical agents associated with environmental toxicity. Currently, there is a growing need to develop eco-friendly processes which do not use toxic chemicals in synthesis methodologies.…”

Section: Prof Dr G V S Nageswara Rao Is a Professor In The Deparmentioning

confidence: 99%

Strategies to synthesize various nanostructures of silver and their applications – a review

et al. 2018

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“…Here comes the issue of method of preparation; ecofriendly and harmless substances as reducing agents and capping chemicals are preferred. Any method therefore that will promote safer and purer form of silvernanoparticles for medical application will be a better option (Leela1 and Vivekanandan, 2008; Jannathul, and Lalitha, 2015; Selvam, et al, 2017). In this work the author intends to use fluted pumpkin (telfairiaoccidentalis)as both reducing agent and capping material for the production of pure AgNPs that can be applied as coating for various medical components to stop infections; including the treatment of wounds.…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis of Eco-Friendly Silver Nano-Particles using Dry Fluted Pumpkin TelfairiaOccidentalisLeave Extractas Reducing Agent

Aondona¹

2018

IJTSRD

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The Biosynthesis of Eco-Friendly Silver Nano Particles using Dry Fluted Pumpkin (TelfairiaOccidentalis) Leave Extract as Reducing Agent was carried out. The research used the extract which was prepared from dry fluted pumpkin leaves to reduce 0.01 M silver nitrate solution without the addition of any capping agent. During the biosynthesis process qualitative measures like 15 minutes interval observation for 1 hr., observation of precipitates formation, and laser light pointer were taken to establish the formation of AgNPs in the solution. The AgNPs for characterization were produced by allowing the biosynthesis solution to remain in the cardboard for 24 hours before filtering and drying the residue in the oven at 110 residue which was the AgNPs was characterized using ED-XRF and SEM. The NPs produced were of average size of 30 nm and angular and cubicle in shape. The chemical composition of the NPs was 71.8% Ag 2 O, 25% SiO 2 , 2.18% Cl and other trace compounds. The NPs; given the eco-friendly method of their biosynthesis can be further purified to be used on wound bandage.

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Eco-friendly biosynthesis and characterization of silver nanoparticles using Tinospora cordifolia (Thunb.) Miers and evaluate its antibacterial, antioxidant potential

Abstract: View related articlesView Crossmark data Citing articles: 28 View citing articles Eco-friendly biosynthesis and characterization of silver nanoparticles using Tinospora cordifolia (Thunb.

Cited by 104 publications

References 31 publications

Increased Oral Bioavailability of Piperine from an Optimized Piper nigrum Nanosuspension

Increased Oral Bioavailability of Piperine from an Optimized Piper nigrum Nanosuspension

Strategies to synthesize various nanostructures of silver and their applications – a review

Biosynthesis of Eco-Friendly Silver Nano-Particles using Dry Fluted Pumpkin TelfairiaOccidentalisLeave Extractas Reducing Agent

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