Eco-efficient ultrasonic responsive synthesis of pyrimidines/pyridines

Abstract

Using ultrasound irradiation, two simple one-pot multicomponent methods are described for syntheses of highly functionalized pyrimidine/pyridine derivatives in excellent yields in the presence of NaOH at room temperature. While one route involved aromatic aldehyde, thiourea and acetoacetanilide, the other employed aromatic aldehyde, malononitrile and benzyl mercaptane or EtOH. These approaches afford several advantages over former and contemporary reaction methodologies in terms of operational simplicity, simple work-up procedure, higher yield, short reaction time and environment friendly protocols.

Use of Ultrasound in the Synthesis of Heterocycles of Medicinal Interest

“…Pagadala et al [82] presented two simple one-pot multicomponent procedures for the synthesis of highly functionalized pyrimidine/pyridine derivatives in higher yields (around 90-95%), with NaOH as an environmentally benign catalyst, at room temperature, using ultrasonication within 2 h (Scheme 23). Synthesis of pyrimidine/pyridine derivatives has been reported by numerous methods [83][84][85][86][87][88][89] previously.…”

KCC-1-NH2-DPA: an efficient heterogeneous recyclable nanocomposite for the catalytic synthesis of tetrahydrodipyrazolopyridines as a well-known organic scaffold in various bioactive derivatives

“…MCRs provide suitable conditions with high demand in advanced organic synthesis. It is especially accurate in case of heterocycle compounds [16] as those reactions comfort formation of various bonds in one-pot operation [17]. Development of several synthetic methodologies to achieve various diversities of pyrazolopyridines derivatives, exhibits the growing interests into these compounds [18].…”

Diastereoselective Sonochemical Synthesis of Spirocyclopropaneoxindoles and Evaluation of Their Antioxidant and Cytotoxic Activities

“…In recent years, ultrasonic chemistry has gained an increasing attention of researchers due to its process intensification in numerous reactions and green nature. [25,26] When an acoustic wave propagates through liquid, it makes alternately bubbles and develops the bubbles oscillate. Bubbles grow to a certain size and finally collapse, releasing energy accumulated within the bubble in a short time.…”