Echocardiographic evaluation of diastolic functions in patients with polycystic ovary syndrome: A comperative study of diastolic functions in sub-phenotypes of polycystic ovary syndrome

Yıldırım, Erkan; Karabulut, Onur; Yuksel, Uygar Cagdas; Çelik, Murat; Buğan, Barış; Gökoğlan, Yalçın; Ulubay, Mustafa; Gungor, Mutlu; Köklü, Mustafa

doi:10.5603/cj.a2017.0032

Cited by 13 publications

(13 citation statements)

References 33 publications

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“…found that hyperandrogenism, value of free androgen index (FAI) > 4.5, waist circumference and waist-to-hip ratio (WHR) were independently associated with higher risk of MetS in logistic regression analysis. 29 Several East Asian, [30][31][32] South Asian, 33,34 Middle Eastern, 35 Turkish 36 and Latin American 37,38 studies demonstrated comparable prevalence of MetS between the four PCOS phenotypes, regardless of BMI of the groups, while others showed highest prevalence of MetS in NIH phenotypes, 12,14,22,39,40 especially in phenotype I. [41][42][43] Similar to Caucasian studies, MetS or its individual components were more frequently diagnosed in PCOS than in controls.…”

Section: Metabolic Syndromementioning

confidence: 73%

“…64 Two studies reported lowest values of systolic (SBP) and diastolic blood pressure (DBP) in patients with normoandrogenic phenotype and healthy controls in comparison to other phenotypes. 24,29 None of East Asian, 14,30-32,44,46,55 Turkish 36,68 or Latin American 37,38 studies demonstrated differences in SBP and DBP or the prevalence of hypertension between the PCOS phenotypes. However, it has been observed that healthy women presented lower values of SBP or DBP in comparison to either all PCOS phenotypes or only to a specific phenotype, most commonly I or II.…”

Section: Caucasian Patients Daskalopoulos Et Al Demonstrated Comparablementioning

confidence: 99%

“…A number of Turkish, [20][21][22]36,68,69 Indian 16,33 and Middle Eastern 35,66,67 studies demonstrated comparable concentrations of HDL-C between the phenotypes. In contrast, Yilmaz et al showed lower concentrations of HDL-C in all phenotypes in comparison to healthy women.…”

Section: Lipid Profilementioning

confidence: 99%

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Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome

Krentowska

Kowalska

2021

Diabetes Metabolism Res

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Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting reproductive-age women. Important factors in its pathogenesis are hyperinsulinaemia and insulin resistance, which lead to higher risk of metabolic syndrome (MetS) and its complications. With the implementation of the Rotterdam diagnostic criteria in 2003, the group of PCOS patients became highly heterogeneous, with varying metabolic risk reported for different phenotypes of the syndrome. The aim of the present review is to assess the prevalence and severity of MetS and its components in patients with the four phenotypes of PCOS. A comprehensive search of Pubmed database was performed to identify studies comparing metabolic characteristics between PCOS patients with different phenotypes of the syndrome. The results of 60 studies published between 2004 and 2020 were retrieved and analysed. More adverse metabolic profile was observed in PCOS patients with hyperandrogenic phenotypes in comparison to normoandrogenic patients, as well as in classic phenotypes, defined by National Institutes of Health criteria, in comparison to newer phenotypes introduced by the Rotterdam criteria. In the majority of observations, normoandrogenic PCOS patients did not differ significantly from controls in terms of metabolic characteristics, although some East Asian studies reported more adverse metabolic profile in normoandrogenic phenotype in comparison to healthy women. In conclusion, metabolic abnormalities in PCOS seem to be associated with joint effects of hyperandrogenism, insulin resistance and visceral obesity. The differences observed between the four phenotypes of PCOS underline the need for individualised diagnostic and therapeutic approach.

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Section: Metabolic Syndromementioning

confidence: 73%

Section: Caucasian Patients Daskalopoulos Et Al Demonstrated Comparablementioning

confidence: 99%

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Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome

Krentowska

Kowalska

2021

Diabetes Metabolism Res

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“…failed to demonstrate a significant difference between PCOS and control groups regarding conventional and Pulsed tissue Doppler parameters of echocardiography 40,41 . A study conducted on PCOS patients in their twenties showed that higher LV mass index and decreased E/A ratio were observed in PCOS patients, which might be suggestive of diastolic dysfunction in its early stage 42 . PCOS women had higher LA diameter, LVMI, and lower LVEF, E/A ratio compared to controls, according to Orio et al 24 .…”

Section: Discussionmentioning

confidence: 99%

“…40,41 A study conducted on PCOS patients in their twenties showed that higher LV mass index and decreased E/A ratio were observed in PCOS patients, which might be suggestive of diastolic dysfunction in its early stage. 42 PCOS women had higher LA diameter, LVMI, and lower LVEF, E/A ratio compared to controls, according to Orio et al 24 And finally, lower peak systolic and diastolic strain rate and peak early diastolic velocity were observed in PCOS patients, suggesting subclinical dysfunction of LV systolic and diastolic activity. 43 PCOS patients are assumed to be at increased risk for CVD 44 and the subclinical LVD is considered as an independent predictor of adverse events in CVD.…”

Section: F I G U R Ementioning

confidence: 91%

The relationship between presystolic wave and subclinical left ventricular dysfunction assessed by myocardial performance ındex in patients with polycystic ovary syndrome

Şaylık¹,

Akbulut²

2021

Echocardiography

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Background: Polycystic ovary syndrome (PCOS) patients have left ventricular dysfunction (LVD) in an earlier stage. Myocardial performance index (MPI) reflects both systolic and diastolic dysfunction. A presystolic wave (PSW) detected on late diastole has been found to be associated with LVD. Aims:We sought to determine whether there is an association between PSW and subclinical LVD assessed by MPI in PCOS patients. Methods:We prospectively enrolled 106 patients diagnosed with PCOS in this study.Patients were divided into two groups based on the presence of PSW. Both groups were compared with respect to demographic, clinical, and echocardiographic properties. Univariable and multivariable regression analyses were performed to detect predictors of subclinical LVD. Results:The study included 58 patients with PSW-positive (54.7%, mean age: 23) and 48 patients with PSW-negative (45.3%, mean age: 25). PSW-positive patients had a higher waist-to-hip ratio, fasting insulin, and HOMA-IR compared to PSW-negative patients. Higher MPI velocities and more frequent subclinical LVD were observed in PSW-positive group than in PSW-negatives (p < 0.001, p = 0.0031, respectively).PSW velocity was significantly correlated with MPI velocity (r:.404, p = 0.0016). The presence of PSW, HOMA-IR, and waist-to-hip ratio > 85 were predictors of subclinical LVD in univariate logistic regression analysis. Only the presence of PSW was an independent predictor of subclinical LVD in multivariable logistic regression analysis (OR:3.257, p = 0.028). Conclusion:PSW prevalence was 54.7% in PCOS patients. PSW velocity was significantly correlated with MPI velocity. The presence of PSW was independently associated with subclinical LVD in PCOS women.

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The influence of sex on left ventricular remodeling in arterial hypertension

Tadić

Cuspidi

2019

Heart Fail Rev

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Echocardiographic evaluation of diastolic functions in patients with polycystic ovary syndrome: A comperative study of diastolic functions in sub-phenotypes of polycystic ovary syndrome

Abstract: Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder among reproductive-aged women. It is known to be associated with cardiovascular diseases. The aim of this (Cariol J 2017; 24, 4: 364-373)

Cited by 13 publications

References 33 publications

Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome

Metabolic syndrome and its components in different phenotypes of polycystic ovary syndrome

The relationship between presystolic wave and subclinical left ventricular dysfunction assessed by myocardial performance ındex in patients with polycystic ovary syndrome

The influence of sex on left ventricular remodeling in arterial hypertension

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