Echocardiographic calcification score in patients with low/intermediate cardiovascular risk

Hirschberg, Kristóf; Reinhart, Manuel; Mereles, Derliz; Uhlmann, Lorenz; André, Florian; Riffel, Johannes; Ochs, Marco; Katus, Hugo A.

doi:10.1007/s00392-018-1343-y

Cited by 7 publications

(3 citation statements)

References 36 publications

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“…The presence of more cardiac calcifications can accelerate atherosclerosis and the development of CAD [9]. Echo-CCS is scored based on calcification in cardiac structures and is an essential indicator of CAD and CV events [10,23]. Previous studies have reported that echo-CCS >2 is an essential risk factor for cardiac events and all-cause mortality [9,23].…”

Section: Discussionmentioning

confidence: 99%

“…Echo-CCS is scored based on calcification in cardiac structures and is an essential indicator of CAD and CV events [10,23]. Previous studies have reported that echo-CCS >2 is an essential risk factor for cardiac events and all-cause mortality [9,23]. Additionally, higher echo-CCS levels have been reported in patients with KOA compared to the control group [11].…”

Section: Discussionmentioning

confidence: 99%

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The Relationship Between Echocardiographic Calcification Score and Grade of Knee Osteoarthritis

Kivrak,

Yildirim,

Horoz

et al. 2023

Cureus

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Background and objectiveIt has been suggested that knee osteoarthritis (KOA) is associated with the development of calcification and an increased risk of cardiovascular (CV) disease, while the contribution of KOA grade is not clearly known enough. This study aimed to investigate the relationship between the grade of KOA, the echocardiographic calcification score (echo-CCS), and CV risk assessment. MethodsThis cross-sectional study involved 204 patients diagnosed with KOA and classified according to the Kellgren-Lawrence staging criteria. Echo-CCS was obtained according to the presence of calcification in the aortic valve, aortic root, mitral ring, papillary muscle and ventricular septum. Framingham risk score (FRS) was used for CV risk assessment. ResultsCalcification was detected in 79.4% of patients . The median FRS, echo-CCS, and high-sensitivity C-reactive protein (hs-CRP) levels increased as the KOA grade increased (p<0.05). A one-grade increase in KOA increased the odds of echo-CCS 1-2 group by 5.15 fold (vs. no calcification group) (OR=5.15, p=0.003), while it increased the odds of echo-CCS ≥3 group by 4.61 fold (vs. echo-CCS 1-2 group) (OR=4.61, p=0.003). Median echo-CSS and hs-CRP were higher in the high CV risk group than in the moderate and low CV risk groups. ConclusionThe majority of patients with KOA had intracardiac calcification. An increased KOA grade was associated with higher echo-CSS and FRS. These findings indicate that patients with higher grades of KOA may be predisposed to developing subclinical atherosclerosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Relationship Between Echocardiographic Calcification Score and Grade of Knee Osteoarthritis

Kivrak,

Yildirim,

Horoz

et al. 2023

Cureus

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“…Although not yet deeply studied in the CKD population, some of these scores can be particularly relevant for CKD at earlier stages where CVD diagnostic is particularly challenging [56,57]. The transthoracic echocardiography-based score (Echo score) [34] showed strong correlation with coronary artery disease (CAD) and association with the CT-scan based score (Agatston) in non CKD patients with low/intermediate CVD risk [58]. The color Doppler ultrasound score (CALCs) [59] was found to be highly correlated with markers of subclinical atherosclerosis, such as the intima-media thickness and arterial stiffness in asymptomatic patients at low-intermediate CVD risk, predicting CVD events beyond the traditional risk factors [35].…”

Section: Ultrasonography Techniquesmentioning

confidence: 99%

Targeting a Silent Disease: Vascular Calcification in Chronic Kidney Disease

Marreiros

Viegas

Simes

2022

IJMS

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Chronic kidney disease (CKD) patients have a higher risk of developing early cardiovascular disease (CVD). Although vascular calcification (VC) is one of the strongest predictors of CVD risk, its diagnosis among the CKD population remains a serious clinical challenge. This is mainly due to the complexity of VC, which results from various interconnected pathological mechanisms occurring at early stages and at multiples sites, affecting the medial and intimal layers of the vascular tree. Here, we review the most used and recently developed imaging techniques, here referred to as imaging biomarkers, for VC detection and monitoring, while discussing their strengths and limitations considering the specificities of VC in a CKD context. Although imaging biomarkers have a crucial role in the diagnosis of VC, with important insights into CVD risk, circulating biomarkers represent an added value by reflecting the molecular dynamics and mechanisms involved in VC pathophysiological pathways, opening new avenues into the early detection and targeted interventions. We propose that a combined strategy using imaging and circulating biomarkers with a role in multiple VC molecular mechanisms, such as Fetuin-A, Matrix Gla protein, Gla-rich protein and calciprotein particles, should represent high prognostic value for management of CVD risk in the CKD population.

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Choroidal thickness is associated with cardiovascular risk factors and cardiac health: the Gutenberg Health Study

et al. 2019

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Echocardiographic calcification score in patients with low/intermediate cardiovascular risk

Abstract: We demonstrated the prevalence of an easily obtainable, radiation-free calcification score in patients with low/intermediate cardiovascular risk. The strong association with CT-calcium scoring may evoke its potential as an alternative method in CV risk assessment.

Cited by 7 publications

References 36 publications

The Relationship Between Echocardiographic Calcification Score and Grade of Knee Osteoarthritis

The Relationship Between Echocardiographic Calcification Score and Grade of Knee Osteoarthritis

Targeting a Silent Disease: Vascular Calcification in Chronic Kidney Disease

Choroidal thickness is associated with cardiovascular risk factors and cardiac health: the Gutenberg Health Study

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