ECG simulations with realistic human membrane, heart, and torso models

Potse, Mark; Dubé, Bruno-Pierre; Gulrajani, R.M.

doi:10.1109/iembs.2003.1279512

Cited by 11 publications

(16 citation statements)

References 11 publications

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“…Conrath and Opthof, 13 for a review), experimental evidence 2,20,27,59 suggests that transmural APD heterogeneity is likely to be the most important factor in the genesis of the normal ECG T-wave shape and polarity. A number of simulation studies 5,14,30,40,41 confirm also this (still debated) postulate. Interestingly, the numerical investigations recently reported in Colli Franzone et al 11 (using a highly idealized geometry) indicate that the polarity of the T-wave (for unipolar ECG leads) may be mainly driven by the cardiac tissue anisotropy.…”

Section: Cell Heterogeneitymentioning

confidence: 50%

“…the monographs 44,47,51 and the references therein), only a small number 28,30,32,41,43,54 addresses the numerical simulation of ECGs using a whole-heart reaction-diffusion (i.e. bidomain or monodomain) model.…”

Section: Introductionmentioning

confidence: 99%

“…bidomain or monodomain) model. Among them, only a very few 41,43 provide meaningful simulations of the complete 12-lead ECG. These simulations rely on a monodomain description of the electrical activity of the heart, a decoupling of the heart and the torso (isolated heart assumption) and a multi-dipole approximation of the cardiac source within the torso (see Sect.…”

Section: Introductionmentioning

confidence: 99%

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Mathematical Modeling of Electrocardiograms: A Numerical Study

et al. 2009

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This paper deals with the numerical simulation of electrocardiograms (ECG). Our aim is to devise a mathematical model, based on partial differential equations, which is able to provide realistic 12-lead ECGs. The main ingredients of this model are classical: the bidomain equations coupled to a phenomenological ionic model in the heart, and a generalized Laplace equation in the torso. The obtention of realistic ECGs relies on other important features--including heart-torso transmission conditions, anisotropy, cell heterogeneity and His bundle modeling--that are discussed in detail. The numerical implementation is based on state-of-the-art numerical methods: domain decomposition techniques and second order semi-implicit time marching schemes, offering a good compromise between accuracy, stability and efficiency. The numerical ECGs obtained with this approach show correct amplitudes, shapes and polarities, in all the 12 standard leads. The relevance of every modeling choice is carefully discussed and the numerical ECG sensitivity to the model parameters investigated.

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Section: Cell Heterogeneitymentioning

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mathematical Modeling of Electrocardiograms: A Numerical Study

et al. 2009

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“…The simulation of 12-lead ECG based on partial differential equations (PDE) -as opposed to cellular automata [64] -appeared during the last decade [5,41,50,51,60]. More recently, a focus on the T-wave was proposed [29,34].…”

Section: Introductionmentioning

confidence: 99%

Numerical simulation of electrocardiograms for full cardiac cycles in healthy and pathological conditions

Schenone

Collin

Gerbeau

2015

Numer Methods Biomed Eng

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This work is dedicated to the simulation of full cycles of the electrical activity of the heart and the corresponding body surface potential. The model is based on a realistic torso and heart anatomy, including ventricles and atria. One of the specificities of our approach is to model the atria as a surface, which is the kind of data typically provided by medical imaging for thin volumes. The bidomain equations are considered in their usual formulation in the ventricles, and in a surface formulation on the atria. Two ionic models are used: the Courtemanche-Ramirez-Nattel model on the atria, and the "Minimal model for human Ventricular action potentials" (MV) by Bueno-Orovio, Cherry and Fenton in the ventricles. The heart is weakly coupled to the torso by a Robin boundary condition based on a resistorcapacitor transmission condition. Various ECGs are simulated in healthy and pathological conditions (left and right bundle branch blocks, Bachmann's bundle block, Wolff-ParkinsonWhite syndrome). To assess the numerical ECGs, we use several qualitative and quantitative criteria found in the medical literature. Our simulator can also be used to generate the signals measured by a vest of electrodes. This capability is illustrated at the end of the article.

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“…However, other studies carried out by (Lines et al 2003;Potse et al 2003;Trudel et al 2004;Keller et al 2007;Potse et al 2009) already considered the bidomain or monodomain approaches, although only (Potse et al 2003;Potse et al 2009) provided the final simulations of the standard ECG leads.…”

Section: Equation 523mentioning

confidence: 99%

Three-dimensional Multiscale Modelling and Simulation of Atria and Torso Electrophysiology

Albero¹

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ECG simulations with realistic human membrane, heart, and torso models

Cited by 11 publications

References 11 publications

Mathematical Modeling of Electrocardiograms: A Numerical Study

Mathematical Modeling of Electrocardiograms: A Numerical Study

Numerical simulation of electrocardiograms for full cardiac cycles in healthy and pathological conditions

Three-dimensional Multiscale Modelling and Simulation of Atria and Torso Electrophysiology

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