Eccrine syringofibroadenoma with co‐existent squamous cell carcinoma

Abstract

Eccrine syringofibroadenoma (ESFA) is a rare, benign adnexal tumor arising most often on the extremities of elderly individuals. It is typically a slow-growing, flesh- to reddish-colored nodule or plaque. Histologically, the tumor consists of anastomosing cords of cuboidal epithelial cells surrounded by a fibrovascular stroma containing plasma cells. The cords contain scattered ductal structures lined with cuboidal cells resembling eccrine ducts. The co-existence of ESFA with squamous cell carcinoma has been described, eliciting the term eccrine syringofibroadenoma. The differential diagnosis includes poroma, porocarcinoma, fibroepithelioma of Pinkus and clear cell acanthoma. ESFA stain positively with epithelial membrane antigen and carcinoembryonic antigen. Cytokeratin studies have been inconsistent.

Clear cell acanthoma with changes of eccrine syringofibroadenoma: reactive change or clue to etiology?

“…Presently, ESFA appears to exist as several distinct clinical subtypes, including solitary lesions, multiple lesions associated with or without syndromal findings and linear lesions. An additional subtype is classified as a reactive entity associated with various inflammatory skin conditions . Regardless of the clinical subtype, the histopathologic findings are similar and include a downward growth of thin, epithelial cords and strands with deep anastomosing connections and luminal structures within the epithelial cords suggesting ductal differentiation.…”

A solitary facial nodule with an uncharacteristic histopathology

“…ESFA has been associated with squamous cell carcinoma (SCC)[34567] and clear cell acanthoma (CCA) as one of the components in the dual tumor. The occurrence of ESFA with SCC has been more prevalent in literature, and the cases encountered have been summarized in Table 1.…”

Multiple lesions by vampire bat bites in a patient in Niterói, Brazil - Case report

“…4 Complications include an association with Squamous Cell Carcinoma and malignant transformation into eccrine syringofibrocarcinoma. 7 There are several etiological factors associated with the development of syringofibroadenoma, among them the HPV type 10. 3 This type of tumor may appear in patients with Clouston syndrome, but it is a rare event, with only 3 cases described in the literature.…”