Eccrine spiradenoma: co‐expression of cytokeratin and smooth muscle actin suggesting differentiation toward myoepithelial cells

Abstract

121nipples. 2,5 Microscopically, it consists of mature sebaceous glands arranged in a band-like pattern in the upper dermis, independent of hair structures and lactiferous ducts. 6 Unilateral-located areolar sebaceous hyperplasia in a male patient has been reported previously only once, 7 so this is the second report of this rare entity. With regard to the origin of this disorder, some authors have proposed that areolar sebaceous hyperplasia in male subjects should be interpreted as a malformation rather than a hyperplasia, hamartoma or adenoma. These authors state that areolar sebaceous hyperplasia may represent hyperplasia of Montgomery tubercles. As men lack Montgomery tubercles, 9 sebaceous hyperplasia might be better interpreted as a malformation. 7 As this is a very infrequent entity, other disorders such as nipple eczema, acanthosis nigricans, hyperkeratosis, and papillomatosis of the nipple should be considered for differential diagnosis. 8 References1 Catalano PM, Ioannides G. Areolar sebaceous hyperplasia. J Am Acad Dermatol 1985; 13: 867-868. 2 Hammerton MD, Shrank AB. Superficial sebaceous hyperplasia of the areolae. Br J Dermatol 1993; 129: 649 -650. 3 Tsuji T, Yamauchi R. Areolar sebaceous hyperplasia with a Fordyce's spot-like lesion. J Dermatol 1994; 21: 524-526. 4 Belinchón I, Aguilar A, Tardío J, Gallego MA. Areolar sebaceous hyperplasia: a case report. Cutis 1996; 58: 63-64. 5 Sánchez Yus E, Montull C, Valcayo A, Robledo A. Areolar sebaceous hyperplasia: a new entity? J Cutan Pathol 1988; 15: 62 -63. 6 Kondo-Morita A, Murata S, Murakami T, Ohtsuki M, Nakagawa H. Bilateral areolar sebaceous hyperplasia in a male.

Expression of keratins in cutaneous epithelial tumors and related disorders - distribution and clinical significance

“…(e) K17 expression in hidroacanthoma simplex: K17, a keratin typical of activated and hyperproliferative keratinocytes, was strongly expressed in tumor cells of hidroacanthoma simplex, reported by Kurokawa et al (69) (with permission) (original magnification, × 100). (f) K17 expression in eccrine spiradenoma: K17, a keratin that also is characteristic of contractile myoepithelial cells, was intensely expressed in tumor cells (together with α‐smooth muscle‐type actin), suggesting that eccrine spiradenoma differentiates to myoepithelial cells, reported by Kurokawa et al (76) (with permission) (original magnification, × 100). (g) K10 expression in intraepidermal eccrine porocarcinoma: K10 is strongly expressed in the intraepidermal tumor cells, reported by Kurokawa et al (100) (with permission) (original magnification, × 40).…”

“…Eccrine spiradenoma: Spiradenoma exhibits a marker spectrum of keratins and α‐smooth muscle‐type actin similar to that of cylindroma (25,73,75–77), suggesting differentiation pathways of secretory, myoepithelial (Fig. 3f) (76) and ductal epithelial cells. One of these reports suggested that eccrine spiradenoma differentiates to the transitional portion between the secretory portion and coiled ducts of eccrine glands (77).…”