Eccrine porocarcinoma

Abstract

Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase. This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma. Histologic evaluation demonstrates anaplastic cells involving the epidermis and infiltrating the dermis. Metastasis to regional lymph nodes distally occurs in a significant number of cases. Treatment modalities have included standard excision, Mohs micrographic surgery (MMS), chemotherapy, and radiation therapy. Recently sentinel lymph node biopsy has begun to be investigated as a staging tool. The literature on EPC is reviewed with attention paid to which of the various therapeutic options offers a clear advantage over the others. MMS affords the greatest likelihood of clear margins and cure in absence of regional and distant metastases.

Radioterapia en porocarcinoma ecrino: revisión de la literatura

“…El porocarcinoma ecrino emerge de la porción ductal intraepidérmica de la glándula sudorípara, específicamente de las células del acrosiringio 9 . Clínicamente se presenta como una lesión nodular (46% de los casos), multinodular (40%) y, en menor medida, en forma de placas, que se pueden acompañar de lesiones verrugosas, atróficas y exofíticas en un 21%, además de úlce-ras 7 .…”

Metastatic Eccrine Porocarcinoma with Indolent Clinical Course

“…EP has been frequently reported in lower extremity, trunk and head (1). The etiology of EP is unclear, however it may arise de novo or evolve from a preexisting benign eccrine poroma (1,2). Malignant transformation may be characterized by pain, itching, spontaneous bleeding, ulceration, and sudden growth (1).…”

“…It is more common in female and advanced aged over 60 years (1,2). EP has been frequently reported in lower extremity, trunk and head (1).…”

“…It is more common in female and advanced aged over 60 years (1,2). EP has been frequently reported in lower extremity, trunk and head (1). The etiology of EP is unclear, however it may arise de novo or evolve from a preexisting benign eccrine poroma (1,2).…”

“…The etiology of EP is unclear, however it may arise de novo or evolve from a preexisting benign eccrine poroma (1,2). Malignant transformation may be characterized by pain, itching, spontaneous bleeding, ulceration, and sudden growth (1). It has a notably risk of locoregional and distant failure (3).…”