Eccrine Angiomatous Harmartoma in an Infant

Abstract

Eccrine angiomatous hamartoma is a nevoid proliferation of eccrine glands and small vessels. It usually presents as a solitary, slow growing nodule, manifesting at birth or in childhood, which can be accompanied by hyperhidrosis and pain on palpation. We report an occurrence in an otherwise healthy 3-month-old girl who had multiple, asymptomatic, nodular lesions with a linear arrangement localized to the inguinal fold. We also review the literature on adnexal hamartomas of infancy.

Eccrine Angiomatous Hamartoma Mimicking a Traumatic Hemorrhage

“…The first of these lesions was documented in 1859 in the description of an angiomatous tumor located on the cheek of a child2. The term EAH was coined in 19683. Other terms such as sudoriparous angioma were used in prior reports3.…”

Painful nodule on forearm

“…Other variants with increased dermal mucin, and the presence of hair follicles or nerve fibers have been described. [2] Verrucous change in overlying epidermis has been reported. Immunohistochemistry shows diminished levels of carcino embryonic antigen and S-100 protein, which are commonly found in the eccrine sweat apparatus.…”

“…The lesions are generally asymptomatic, however, focal hyperhidrosis, hypertrichosis, and pain can be observed. [2] Infiltration of nerves among the eccrine glands may be responsible for the pain. [3] Rapid growth may occur during puberty and pregnancy, suggesting underlying hormonal influence.…”

“…In sudoriparous angioma, the angiomatous component predominates, and the eccrine glands show dilatation instead of proliferation. [2] Eccrine nevus is composed of mature eccrine glands without angiomatous proliferation. [2] EAH is a benign tumor and does not require aggressive treatment when asymptomatic.…”

“…[2] Eccrine nevus is composed of mature eccrine glands without angiomatous proliferation. [2] EAH is a benign tumor and does not require aggressive treatment when asymptomatic. Spontaneous regression may occur.…”