Ebola virus disease: a literature review

Kimura, Hirokazu; Tsukagoshi, Hiroyuki; Ryo, Akihide; Oda, Yoshiroh; Kawabata, Toshinobu; Majima, Takashi; Kozawa, Kunihisa; Shimojima, Masayuki; Prefectural, Gunma

doi:10.12980/jclm.3.201514j93

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…HIV/AIDS is a life-threatening disease. In 2019, about 38 million people worldwide were living with HIV, and 690,000 deaths had occurred in that year 12 . An estimated 20.6 million of these live in eastern and southern Africa 13 .…”

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2022

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Severe viral infections like Covid-19 are emerging now a day and are the common causes of human illness and death. Presently, we have a limited availability of antiviral chemotherapeutic agents to prevent and treat these infections, so it is the need of an hour to develop potential antiviral drugs against various harmful and fatal viral infections. A large quantity of research has been performed on 1,2,3 triazole and their derivatives, which has proved the promising antiviral activity of this heterocyclic nucleus. Among nitrogen-containing heterocyclic compounds, 1, 2, 3-triazoles are privileged structure motifs and received great attention in academics and industry. Even though absent in nature, 1, 2, 3-triazoles have found broad applications in drug discovery, organic synthesis, polymer chemistry, supramolecular chemistry, bioconjugation, chemical biology, fluorescent imaging, and materials science. 1, 2, 3 triazole nucleus is one of the most important and well-known heterocycle which is a common and integral skeleton of a variety of medicinal compounds like antidepressant, antihistaminic, antioxidant, antitubercular, anti-Parkinson, antineoplastic, antihypertensive, antimalarial, local anaesthetic, antianxiety, antiobesity and immunomodulatory agents, etc.1, 2, 3 triazole emerged as a pharmacologically significant scaffolds due to its broad and potent activity against severe infections. This review primarily lays emphasis on the recent advancements in the synthesis and biological evaluation of 1, 2, 3 triazole derivatives as antiviral agents which may facilitate the development of more potent and effective antiviral agents. INTRODUCTION:A virus is the smallest type of parasite to exist, usually ranging from 0.02 to 0.3μm in size, although some viruses can be as large as 1μm. They are about 1/100 th of the size of bacteria 1 .

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2022

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Plants to Drugs: A Case Study of Human Papilloma Virus and Traditional Chinese Medicine

Rahmatullah

Rahman

Hasan

et al. 2022

Promising Antimicrobials From Natural Products

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Stock market reactions to COVID-19 shocks: do financial market interventions walk the talk?

Marobhe

Kansheba

2022

CFRI

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PurposeFollowing the COVID-19 outbreak, various economies imposed different financial interventions as part of initiatives to cushion their stock markets from deteriorating performance. Our article examines the effectiveness of these interventions in protecting stock markets during the pandemic.Design/methodology/approachThe authors employ Panel Vector Autoregression to model the magnitude and timing of shocks from COVID-19 to stock markets. The fixed effects regression is then utilized to assess the role of financial interventions in protecting stock markets during COVID-19. The study uses daily stock index returns as well COVID-19 containment measures stringency index data from 39 countries ranging from 2nd January 2020 to 30th September 2021.FindingsOur findings firstly reveal a significant positive stock market reaction to country-level containment measures stringency but only during the first wave of COVID-19. We secondly show that stock market functioning interventions that include short selling bans and circuit breakers amplify the positive effects of COVID-19 containment measures stringency on stock market performance.Research limitations/implicationsThe authors stress the need for policymakers and regulators to timely intervene in protecting economies and stock markets during crises such as COVID-19 in order to reduce panic among investors. Moreover, investors should adjust their portfolios by investing in stocks from countries that have proper financial market interventions in place.Originality/valueDespite growing body of literature on COVID-19 and stock market performance, there is limited evidence on the role of financial sector interventions to cushion stock markets during tumultuous conditions caused by the pandemic.

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Ebola virus disease: a literature review

Cited by 4 publications

References 34 publications

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Plants to Drugs: A Case Study of Human Papilloma Virus and Traditional Chinese Medicine

Stock market reactions to COVID-19 shocks: do financial market interventions walk the talk?

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