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Abstract

Severe viral infections like Covid-19 are emerging now a day and are the common causes of human illness and death. Presently, we have a limited availability of antiviral chemotherapeutic agents to prevent and treat these infections, so it is the need of an hour to develop potential antiviral drugs against various harmful and fatal viral infections. A large quantity of research has been performed on 1,2,3 triazole and their derivatives, which has proved the promising antiviral activity of this heterocyclic nucleus. Among nitrogen-containing heterocyclic compounds, 1, 2, 3-triazoles are privileged structure motifs and received great attention in academics and industry. Even though absent in nature, 1, 2, 3-triazoles have found broad applications in drug discovery, organic synthesis, polymer chemistry, supramolecular chemistry, bioconjugation, chemical biology, fluorescent imaging, and materials science. 1, 2, 3 triazole nucleus is one of the most important and well-known heterocycle which is a common and integral skeleton of a variety of medicinal compounds like antidepressant, antihistaminic, antioxidant, antitubercular, anti-Parkinson, antineoplastic, antihypertensive, antimalarial, local anaesthetic, antianxiety, antiobesity and immunomodulatory agents, etc.1, 2, 3 triazole emerged as a pharmacologically significant scaffolds due to its broad and potent activity against severe infections. This review primarily lays emphasis on the recent advancements in the synthesis and biological evaluation of 1, 2, 3 triazole derivatives as antiviral agents which may facilitate the development of more potent and effective antiviral agents. INTRODUCTION:A virus is the smallest type of parasite to exist, usually ranging from 0.02 to 0.3μm in size, although some viruses can be as large as 1μm. They are about 1/100 th of the size of bacteria 1 .

1,2,3-Triazoles and their metal chelates with antimicrobial activity

“…Nitrogen heterocycles have been extensively studied for their overall medicinal properties ( Heravi and Zadsirjan, 2020 ; Kerru et al, 2020 ) and in particular—antimicrobial activity, both antibacterial and antifungal. 1,2,3-Triazoles, in particular, have gained attention due to their structural versatility and potential for diverse biological activities—antimicrobial ( Banu et al, 1999 ; Yadav et al, 2023 ), antiviral ( Viegas et al, 2020 ; Chopade and Shaikh, 2022 ), anticancer ( Slavova et al, 2020 ; Alam, 2022 ), anti-inflammatory ( Kuntala et al, 2021 ; Matin et al, 2022 ), central nervous system ( Silalai et al, 2022 ; Khan et al, 2023 ), anti-SARS-CoV-2 ( Hamadi et al, 2022 ) to name a few. A vast amount of experimentation and literature reports on novel antimicrobial 1,2,3-triazoles has been accumulated over the years and the pace of research efforts seems to only accelerate.…”