East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease

Sharma, Manju; Levenson, Corey; Browning, John; Becker, Emily; Clements, Ian P.; Castella, Paul; Cox, Michael

doi:10.3389/fphar.2018.00200

Cited by 16 publications

(7 citation statements)

References 67 publications

(97 reference statements)

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“…The inhibition efficiency of FT oil (133.7 μg/mL) was about 78%, indicating its potential anti-inflammatory value. As reference, the aqueous extract of nutmeg showed over 90% inhibition efficiency on PDE-5 at 500 μg/mL [25]; in a cell model test, East Indian sandalwood oil showed about 70% inhibition efficiency on PDEs ata concentration of 0.0001–0.0002% [26].…”

Section: Resultsmentioning

confidence: 99%

Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

et al. 2019

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Polymethylene-interrupted polyunsaturated fatty acids (PMI-PUFAs) are emerging functional lipids with proven antioxidant and anti-inflammatory effects. In this study, a typical PMI-PUFA, sciadonic acid (C20:3, 5c 11c 14c), was enriched in the kernel oil of Torreya fargesii (T. fargesii) by fractionation. Fractionated kernel oil of T. fargesii (containing 25% sciadonic acid) showed equal stability and similar radical scavenging ability compared with the non-fractionated oil. In anti-inflammatory tests, fractionated kernel oil was shown to inhibit the activity of phosphodiesterase (PDE-5, efficiency 80% at 133.7 μg/mL) and lipoxygenase-5 (LOX-5, efficiency 65% at 66.7 μg/mL) more effectively than the non-fractionated oil. This shows that increasing the amount of sciadonic acid can enhance the anti-inflammatory effect of the kernel oil. This research also indicates that fractionation is a feasible way to obtain sciadonic acid–rich functional oil with potential pharmacological effects.

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Section: Resultsmentioning

confidence: 99%

Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

et al. 2019

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“…Telah dilakukan juga beberapa penelitian yang membuktikan secara in vitro maupun in vivo mengenai efektivitas dari minyak Cendana sebagai antiinflamasi (Baylac, 2003;Li dkk., 2013;Puspawati dkk., 2017;M. Sharma dkk., 2014;Manju Sharma dkk., 2017, 2018. Bahkan menurut review dari Jain dan Nair, (2019) minyak Cendana memiliki khasiat lain selain antiinflamasi, yaitu penanganan pada dermatitis akibat radiasi, penanganan eczema dan psoriasis, penanganan pasien kronis angina pectoris, memiliki efek antivirus, efek antibakteri, efek antifungi, dan berpotensi sebagai antikanker kulit, serta memiliki profi keamanan yang dapat diterima dengan baik.…”

Section: Pendahuluanunclassified

Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory

Suena

Ariani

Antari

2022

JINTO

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Inflammation is the body's defense response used to fight agents that cause cell damage in an organism. One source of natural ingredients whose content can be developed as an anti-inflammatory with low side effects is Sandalwood (Santalum album L.). The pharmaceutical preparation chosen for the development of Sandalwood oil as an anti-inflammatory is a cream, because of its several advantages, namely, it is more convenient, practical, easy to use, not sticky, and easy to wash with water so it is easy to clean. The purpose of this study was to determine the physical quality of sandalwood oil cream using two variant concentrations of surfactant sodium lauryl sulfate 1.5% (F1) and 2.5% (F2) as an emulsifying agent, as well as to determine consumer perceptions of sandalwood oil cream. In ensuring pharmaceutical quality, the preparations made must meet several physical parameters including organoleptic tests, homogeneity tests, pH tests, mechanical stability tests, dispersibility tests, and hedonic tests. To find out whether there is a significant difference between F1 and F2, statistical data processing of cream physical quality was performed using SPSS 20 with an unpaired T-test if the data were normally distributed, and if the data were not normally distributed, the Mann-Whitney test was performed. The results of the research that has been carried out show that overall the two cream formulas have good physical quality and are quite liked by the panelists. From the results of the organoleptic test, homogeneity test, and pH test, it is known that F1 and F2 have no difference, and the results of the dispersion test and hedonic test show that there is no significant difference between F1 and F2.

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“…Sandalwood oil has a very pleasant and lasting scent and is widely used in the food and cosmetic industries . This naturally occurring product has also shown therapeutic and chemotherapeutic potentials for the treatment of skin diseases and some cancers. − Sandalwood oil is traditionally steam-distilled from the heartwood and the roots of matured Indian sandalwood (Santalum album L.), a slow-growing fragrant tree . This traditional extraction suffers from a low yield and overharvesting of the sandalwood trees.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Engineering of Escherichia coli for Production of α-Santalene, a Precursor of Sandalwood Oil

Wang

Zhou

Liu

et al. 2021

J. Agric. Food Chem.

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α-Santalene belongs to a class of natural compounds with many physiological functions and medical applications. Advances in metabolic engineering enable non-native hosts (e.g., Escherichia coli) to produce α-santalene, the precursor of sandalwood oil. However, imbalances in enzymatic activity often result in a metabolic burden on hosts and repress the synthetic capacity of the desired product. In this work, we manipulated ribosome binding sites (RBSs) to optimize an α-santalene synthetic operon in E. coli, and the best engineered E. coli NA-IS 3D strain could produce α-santalene at a titer of 412 mg•L −1 . Concerning the observation of the inverse correlation between indole synthesis and α-santalene production, this study speculated that indoleassociated amino acid metabolism would be competitive to the synthesis of α-santalene rather than indole toxicity itself. The deletion of tnaA could lead to a 1.5-fold increase in α-santalene production to a titer of 599 mg•L −1 in E. coli tnaA − NA-IS 3D . Our results suggested that the optimization of RBS sets of the synthetic module and attenuation of the competitive pathway are promising approaches for improving the production of terpenoids including α-santalene.

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East Indian Sandalwood Oil Is a Phosphodiesterase Inhibitor: A New Therapeutic Option in the Treatment of Inflammatory Skin Disease

Cited by 16 publications

References 67 publications

Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

Fractionated Antioxidant and Anti-inflammatory Kernel Oil from Torreya fargesii

Physical Evaluation and Hedonic Test of Sandalwood Oil (Santalum album L.) Cream as an Anti-Inflammatory

Metabolic Engineering of Escherichia coli for Production of α-Santalene, a Precursor of Sandalwood Oil

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