East/Central/South African Genotype Chikungunya Virus, Brazil, 2014

Teixeira, Maria da Glória Lima Cruz; Andrade, Alcina M. S; Costa, Maria da Conceição Nascimento; Castro, Jesuína S. M; Oliveira, Francisca L S; Goes, Cristina S. B; Maia, Maricelia Lima; Santana, Eloisa Bahia; Nunes, Bruno Tardelli Diniz; Vasconcelos, Pedro Fernando da Costa

doi:10.3201/eid2105.141727

Cited by 97 publications

(87 citation statements)

References 3 publications

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“…Different genotypes have been found in the Americas; the British Virgin Islands and other Caribbean Islands have confirmed the presence of Asian genotype [6], whereas the ECSA genotype was found recently in Brazil [23]. It is important to identify the genotype involved in the Colombian outbreak because the presence of particular genotypes has been associated with more severe clinical manifestations, high pathogenicity or virulence, mortality, and even enhancement of mosquito infectivity [24].…”

Section: Discussionmentioning

confidence: 99%

Outbreak of Chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis

Máttar

Miranda

Pinzón

et al. 2015

J Infect Dev Ctries

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Introduction: The Caribbean area of Colombia has been severely affected by a Chikungunya virus (CHIKV) outbreak since 2014. Methodology: The study was carried out on 100 patients during a fever outbreak from August to September 2014 in two small rural villages in the northern Caribbean area of Colombia. The molecular assays performed by reverse transcription polymerase chain reaction (RT-PCR) on acute patient sera were collected within one to five days of the appearance of symptoms. Sequence analyses were carried out based on phylogenetic analyses of genes NS1 and E2. For serological assays, 49 (49%) patients at ≥ 6 days of disease onset were tested with NovaLisa Chikungunya IgG/IgM μ-capture enzyme-linked immunosorbent assay (ELISA). Results: The main signs or symptoms associated with Chikungunya infection were arthralgia of the lower limbs (96%), fever (91%), arthralgia of the upper limbs (85%), rash (64%), and headache (57%). Ninety-four percent (46/49) of patients were positive for either IgM or IgG; the remaining three (6%) patients were seronegative. Viral loads were detected in 25 patients. Based on phylogenetic analysis of NS1 and E2, the characterization of the Colombian CHIKV indicated that it was a strain closely related to the British Virgin Islands strain and to the Asian genotype. Conclusions: This study shows the phylogenetic and clinical description of CHIKV in Colombia. The main symptoms shown were: arthralgia, fever, and rash. CHIKV sequences detected in Colombian patients were within the Asian genotype and closely related to the British Virgin Islands strain.

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Section: Discussionmentioning

confidence: 99%

Outbreak of Chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis

Máttar

Miranda

Pinzón

et al. 2015

J Infect Dev Ctries

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“…YFV, Saint Louis encephalitis virus, Mayaro virus, and Oropouche virus also circulate in some parts of Brazil (188). CHIKV strains belonging to the Asian (189) and East, Central, and South African (190) lineages have circulated in Brazil since September 2014.…”

Section: Emergence Of Zikv In the Americasmentioning

confidence: 99%

Zika Virus

2016

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SUMMARYZika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genusFlavivirusand the familyFlaviviridae. ZIKV was first isolated from a nonhuman primate in 1947 and from mosquitoes in 1948 in Africa, and ZIKV infections in humans were sporadic for half a century before emerging in the Pacific and the Americas. ZIKV is usually transmitted by the bite of infected mosquitoes. The clinical presentation of Zika fever is nonspecific and can be misdiagnosed as other infectious diseases, especially those due to arboviruses such as dengue and chikungunya. ZIKV infection was associated with only mild illness prior to the large French Polynesian outbreak in 2013 and 2014, when severe neurological complications were reported, and the emergence in Brazil of a dramatic increase in severe congenital malformations (microcephaly) suspected to be associated with ZIKV. Laboratory diagnosis of Zika fever relies on virus isolation or detection of ZIKV-specific RNA. Serological diagnosis is complicated by cross-reactivity among members of theFlavivirusgenus. The adaptation of ZIKV to an urban cycle involving humans and domestic mosquito vectors in tropical areas where dengue is endemic suggests that the incidence of ZIKV infections may be underestimated. There is a high potential for ZIKV emergence in urban centers in the tropics that are infested with competent mosquito vectors such asAedes aegyptiandAedes albopictus.

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“…CHIKV was introduced to the Americas in 2013 and, since September 2014, autochthonous cases have been confi rmed in Brazil, with at least two genotypes circulating in the country (5) (6) (7) . An imported case had previously been reported in Rio de Janeiro in 2010 (8) .…”

Section: Chikv Is Transmitted By the Bite Of Infected Mosquitoes (Aedmentioning

confidence: 99%

A case of chikungunya virus disease presenting with remarkable acute arthritis of a previously damaged finger joint

Eyer-Silva

Neto²,

Silva

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Chikungunya virus (CHIKV) is a mosquito-borne arthritogenic alphavirus that has recently been introduced to Brazil. We report the case of a 36-year-old male patient from the City of Rio de Janeiro who developed molecularly-confi rmed CHIKV disease and whose clinical picture was remarkable because of acute arthritis of an interphalangeal joint that had been damaged by trauma 8 years previously. This case illustrates that acute CHIKV disease may preferentially target previously damaged joints. Careful study of individual cases may provide valuable information on the presentation and management of this emerging zoonosis in Brazil.

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East/Central/South African Genotype Chikungunya Virus, Brazil, 2014

Cited by 97 publications

References 3 publications

Outbreak of Chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis

Outbreak of Chikungunya virus in the north Caribbean area of Colombia: clinical presentation and phylogenetic analysis

Zika Virus

A case of chikungunya virus disease presenting with remarkable acute arthritis of a previously damaged finger joint

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