Earthquakes – A Historical Review, Environmental and Health Effects, and Health Care Measures

Nola, Iskra Alexandra; Jelinić, Jagoda Doko; Zuśkin, E; Kratohvil, Mladen

doi:10.2478/10004-1254-64-2013-2304

Cited by 4 publications

(3 citation statements)

References 17 publications

(14 reference statements)

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“…Obesity and obesity-associated metabolic disorders are serious and global public health problems (1,2). Although many factors (including genetic, physiological, medicinal, and behavioral factors) participate in the etiology of obesity (3), the most common reason leading to this metabolic disorder is a long-term imbalance between food intake and energy expenditure (4,5). Over the past 50 years, accompanied by the increase in high-fat and highsugar diets, as well as insufficient physical activity (6, 7), ∼1.9 billion adults in the world were overweight and at least 650 million of them were obese (8,9).…”

Section: Introductionmentioning

confidence: 99%

Discovery and Characterization of the Naturally Occurring Inhibitors Against Human Pancreatic Lipase in Ampelopsis grossedentata

et al. 2022

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Pancreatic lipase (PL) inhibitor therapy has been validated as an efficacious way for preventing and treating obesity and overweight. In the past few decades, porcine PL (pPL) is widely used as the enzyme source for screening the PL inhibitors, which generates a wide range of pPL inhibitors. By contrast, the efficacious inhibitors against human PL (hPL) are rarely reported. This study aims to discover the naturally occurring hPL inhibitors from edible herbal medicines (HMs) and to characterize the inhibitory mechanisms of the newly identified hPL inhibitors. Following the screening of the inhibition potentials of more than 100 HMs against hPL, Ampelopsis grossedentata extract (AGE) displayed the most potent hPL inhibition activity. After that, the major constituents in AGE were identified and purified, while their anti-hPL effects were assayed in vitro. The results clearly showed that two abundant constituents in AGE (dihydromyricetin and iso-dihydromyricetin) were moderate hPL inhibitors, while myricetin and quercetin were strong hPL inhibitors [half-maximal inhibitory concentration (IC50) values were around 1.5 μM]. Inhibition kinetic analyses demonstrated that myricetin and quercetin potently inhibited hPL-catalyzed near-infrared fluorogenic substrate of human pancreatic lipase (DDAO-ol) hydrolysis in a non-competitive inhibition manner, with Ki values of 2.04 and 2.33 μM, respectively. Molecular dynamics simulations indicated that myricetin and quercetin could stably bind on an allosteric site of hPL. Collectively, this study reveals the key anti-obesity constituents in AGE and elucidates their inhibitory mechanisms against hPL, which offers convincing evidence to support the anti-obesity and lipid-lowering effects of this edible herb.

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Section: Introductionmentioning

confidence: 99%

Discovery and Characterization of the Naturally Occurring Inhibitors Against Human Pancreatic Lipase in Ampelopsis grossedentata

et al. 2022

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“…It is also the place, the environment in which an earthquake happens. 11 We can say the earthquake danger goes all over the world. Thus, knowing the possible consequences of such disaster makes us stronger in preparing our disaster relief organizations, state agencies, and people.…”

Section: Introductionmentioning

confidence: 99%

“…It goes over the Pacific Ocean and on the other side goes from Aleutian Islands to Japan, Filipinas, New Guinea, Southwest Pacific islands till the New Zealand. This belt covers almost 81% of all earthquakes' released energy.10,11 The Mediterranean/ Trans-Asian belt goes from Canary Islands through Gibraltar, Mediterranean Sea, Apennine and Balkan Peninsula, through Turkey to part of Asia where it goes on through Caucasus and Armenian mountains over the Iranian plateau and Himalaya till Thailand, Sumatra and Java, where it is connected to the Circum-Pacific belt.…”

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confidence: 99%

Earthquakes and their environmental, medical and public health impacts

Nola

2018

Salud Publica Mex

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Earthquakes are probably the scariest among the natural disasters that teach us about the forces of nature and their unpredictability. Knowing that there is nothing we can do to prevent the occurrence of an earthquake, we are forced to learn from our own experience. This paper systematizes the environmental, medical and public health impacts of earthquakes. Each is presented in a structured way, highlighting its most important aspects. The relationship between them and the affected environment and population; as well as the connection between these are emphasized during earthquakes. The environment at the place of occurrence of an earthquake is important for the survival of victims and also defines the particular medical and public health needs arising from its specificity. Every country needs good disaster management with specific protocols for the expected type of disaster. These protocols must incorporate environmental, medical and public health aspects and their implementation must be very efficient; they must include educating the inhabitants; training teams involved in rescue, (eventual) migration/ evacuation, medical treatments and public health actions, and training and educating leaders.

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A case study of complex disasters within the resilience framework in Zagreb, Croatia: Two earthquakes in one pandemic

Svetina

Ćurković

Alexandra

2022

Environmental Research

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Earthquakes – A Historical Review, Environmental and Health Effects, and Health Care Measures

Cited by 4 publications

References 17 publications

Discovery and Characterization of the Naturally Occurring Inhibitors Against Human Pancreatic Lipase in Ampelopsis grossedentata

Discovery and Characterization of the Naturally Occurring Inhibitors Against Human Pancreatic Lipase in Ampelopsis grossedentata

Earthquakes and their environmental, medical and public health impacts

A case study of complex disasters within the resilience framework in Zagreb, Croatia: Two earthquakes in one pandemic

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