Earth-friendly-assessed chromatographic platforms for rapid analysis of sulfacetamide sodium and prednisolone acetate in presence of sulfanilamide impurity: Application on ophthalmic formulation and aqueous humor

Sayed, Rania A.; Mohamed, Ahmed R.; Hаssаn, Wаfаа S.; Elmasry, Manal S.

doi:10.1016/j.scp.2022.100694

Cited by 10 publications

(6 citation statements)

References 10 publications

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“…Several methods have been reported for the determination of sulphacetamide using different techneques such as spectrophotometric methods [13][14][15], chromatographic methods [16][17], also electrochemical methods [18][19] .The aim of this work is to development of a simple spectrophotometric method for the determination of sulphacetamide sodium in its pharmaceutical preparations .…”

Section: G/molmentioning

confidence: 99%

Spectrophotometric Determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as Coupling Reagent

Abdulrazzaq¹,

Sultan²

2023

CBERJ

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A Sensitive, rapid and selective spectrophotometric method was developed for the determination of sulfacetamide sodium in an aqueous solution. The method is based on the oxidative coupling reaction with 2,4-dinitophenylhydrazine in the basic medium in the presence of potassium periodate to produce an intense orange colour product, soluble in water, stable and gives maximum absorbance at 484 nm. The linearity of Beer's law was in the range of 2.5-75 μg/ml of sulfacetamide. The molar absorptivity, Sandellʼs sensitivity, and detection limit were 3202.92 L/mol.cm, 0.07936 µg/cm2 and 0.50476 μg/ml respectively. This method is applied successfully to the determination of sulfacetamide in pharmaceutical preparation (eye drops and ointment).

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Section: G/molmentioning

confidence: 99%

Spectrophotometric Determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as Coupling Reagent

Abdulrazzaq¹,

Sultan²

2023

CBERJ

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“…This is due to the fact that some side components may greatly affect the safety and effectiveness of drugs. High-performance (HP) liquid chromatography (LC) with UV detection [ 1 , 2 ], reversed-phase HPLC with photodiode array [ 3 , 4 , 5 ], UV [ 6 , 7 ] or fluorescence [ 7 ] detectors, HP thin-layer chromatography with densitometry [ 1 , 2 , 4 ], capillary zone electrophoresis [ 8 , 9 , 10 ], and spectrophotometry combined with chemometrics [ 11 , 12 , 13 , 14 , 15 , 16 ] can be used to control the degradation and purity of drugs. At the same time, there are two main approaches to the analysis.…”

Section: Introductionmentioning

confidence: 99%

“…At the same time, there are two main approaches to the analysis. In the first case, active ingredients are determined in the presence of side components so that the content of the latter does not influence an analytical signal [ 1 , 2 , 3 , 8 , 11 , 12 ]. The second approach is the simultaneous determination of drug components, including related organic impurities and degradation products [ 4 , 5 , 6 , 7 , 9 , 10 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Sensor Arrays Based on Hybrid PFSA/CNTs Membranes for the Analysis of UV-Degraded Drugs

et al. 2023

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The degradation of drugs is a substantial problem since it affects the safety and effectiveness of pharmaceutical products, as well as their influence on the environment. A novel system of three potentiometric cross-sensitive sensors (using the Donnan potential (DP) as an analytical signal) and a reference electrode was developed for the analysis of UV-degraded sulfacetamide drugs. The membranes for DP-sensors were prepared by a casting procedure from a dispersion of perfluorosulfonic acid (PFSA) polymer, containing carbon nanotubes (CNTs), whose surface was preliminarily modified with carboxyl, sulfonic acid, or (3-aminopropyl)trimethoxysilanol groups. A correlation between the sorption and transport properties of the hybrid membranes and cross-sensitivity of the DP-sensor to sulfacetamide, its degradation product, and inorganic ions was revealed. The analysis of the UV-degraded sulfacetamide drugs using the multisensory system based on hybrid membranes with optimized properties did not require a pre-separation of the components. The limits of detection of sulfacetamide, sulfanilamide, and sodium were 1.8 × 10−7, 5.8 × 10−7, and 1.8 × 10−7 M. The relative errors of the determination of the components of the UV-degraded sulfacetamide drugs were 2–3% (at 6–8% relative standard deviation). PFSA/CNT hybrid materials provided the stable work of the sensors for at least one year.

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“…As a result, a steady decline in interest to them is observed. Despite a large number of publications devoted to determination of 4-aminobenzenesulfonic acid derivatives, there are practically no methods for their determination in the presence of the primary member of the class (sulfanilamide) in the UV-degraded pharmaceuticals [35,36].…”

Section: Introductionmentioning

confidence: 99%

Multisensory Systems Based on Perfluorosulfonic Acid Membranes Modified with Polyaniline and PEDOT for Multicomponent Analysis of Sulfacetamide Pharmaceuticals

et al. 2022

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The degradation of sulfacetamide with the formation of sulfanilamide leads to a deterioration in the quality of pharmaceuticals. In this work, potentiometric sensors for the simultaneous determination of sulfanilamide, sulfacetamide and inorganic ions, and for assessing the degradation of pharmaceuticals were developed. A multisensory approach was used for this purpose. The sensor cross-sensitivity to related analytes was achieved using perfluorosulfonic acid membranes with poly(3,4-ethylenedioxythiophene) or polyaniline as dopants. The composite membranes were prepared by oxidative polymerization and characterized using FTIR and UV-Vis spectroscopy, and SEM. The influence of the preparation procedure and the dopant concentration on the membrane hydrophilicity, ion-exchange capacity, water uptake, and transport properties was investigated. The characteristics of the potentiometric sensors in aqueous solutions containing sulfanilamide, sulfacetamide and alkali metals ions in a wide pH range were established. The introduction of proton-acceptor groups and π-conjugated moieties into the perfluorosulfonic acid membranes increased the sensor sensitivity to organic analytes. The relative errors of sulfacetamide and sulfanilamide determination in the UV-degraded eye drops were 1.2 to 1.4 and 1.7 to 4%, respectively, at relative standard deviation of 6 to 9%.

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Earth-friendly-assessed chromatographic platforms for rapid analysis of sulfacetamide sodium and prednisolone acetate in presence of sulfanilamide impurity: Application on ophthalmic formulation and aqueous humor

Cited by 10 publications

References 10 publications

Spectrophotometric Determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as Coupling Reagent

Spectrophotometric Determination of Sulphacetamide Sodium Using 2,4-Dinitrophenylhydrazine as Coupling Reagent

Potentiometric Sensor Arrays Based on Hybrid PFSA/CNTs Membranes for the Analysis of UV-Degraded Drugs

Multisensory Systems Based on Perfluorosulfonic Acid Membranes Modified with Polyaniline and PEDOT for Multicomponent Analysis of Sulfacetamide Pharmaceuticals

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